Pattern reversal visual evoked potentials in children with migraine or tension-type headache

Pattern reversal visual evoked potentials were recorded in 71 children with different types of migraine (e.g. migraine with aura, migraine without aura) or tension-type headache and in 19 controls (mean age of both groups 9 years). P100 latencies were comparable in all three groups.     

Use of a Model Wellness Policy May Not Increase the Strength and Comprehensiveness of Written School Wellness Policies

BACKGROUND

Many state agencies have developed model wellness policies (MWPs) to serve as examples for schools when writing their own school wellness policy (SWP). The purpose of this study was to evaluate if a MWP aids schools in writing stronger, more comprehensive SWPs.

METHODS

For this cross‐sectional study, 91 school districts submitted their current SWP and completed a survey that classified districts into either districts that utilized the state MWP (N = 56; 61.5%) or those that did not (NMWP, N =35; 38.5%). The Wellness School Assessment Tool (WellSAT) was used to assess the strength, comprehensiveness, total overall score, and subsection scores of each policy. Dependent variables were compared between groups using t tests. Statistical significance was set at p ≤ .05. Data are presented as mean ±SD.

RESULTS

No significant differences were found between groups in total overall (MWP 76.8 ± 37.9; NMWP 62.1 ± 34.3), strength (MWP 25.3 ± 17.6; NMWP 19.1 ± 12.8), or comprehensiveness scores (MWP 51.5 ± 21.2; NMWP 43.0 ± 22.1). The only subsection score difference identified between groups was the Nutrition Standards comprehension score (p = .02).

CONCLUSIONS

These data suggest MWPs may not improve the quality of written SWPs. Further research is needed to better understand the needs of school districts in SWP development.

     

胃癌中微卫星不稳定性及DNA错配修复系统

1993年Altonen[1]首次发现遗传性非息肉病性大肠癌(herediary nonpolyposis colorectal cancer,HNPCC)细胞中存在高频率微卫星不稳定性(MSI)以后,许多学者相继发现在多种肿瘤中存在着微卫星不稳定性[2-6].DNA错配修复系统的发现,使微卫星不稳定性的起源得到深入的研究.近年来胃癌中微卫星不稳定性及其可能的致癌机制成为研究的热点,东西方学者由于地域、人群及研究的方法不同,对此研究存在不少争议[7-15].     

木犀草素体外抗柯萨奇B3病毒的作用

目的：了解木犀草素体外抗柯萨奇Ｂ３病毒的作用及其机制。方法：采用组织培养法,通过ＣＰＥ观察药物对ＨｅＬａ细胞的最大无毒浓度,柯萨奇Ｂ３病毒的滴度。药物抗病毒实验,使用染料摄入法测定细胞存活情况。结果：本犀草素的最大无细胞毒浓度为９．７５ｕｌ／ｍｌ。经不同时间给药,木犀草素在０．３０～９．７５ｕｇ／ｍｌ浓度范围内,对ＣｏｘＢ３病毒均有显著的抑制细胞病变作用。结论：木犀草素具有体外抗ＣｏｘＢ３病毒作用     

葛根素对小鼠实验性微循环障碍的改善作用

本文报告了葛根素对肾上腺素(Adr)引起的小鼠肠系膜微循环障碍的影响,并与罂粟碱作比较。结果表明,预先局部滴注0.5%葛根素能够拮抗Adr所致微动脉收缩、流速减慢和流量减少;而局部先滴注Adr造成微循环障碍后,再局部滴注1%葛根素,获得与上类似结果。给小鼠ⅳ葛根素(52 mg/kg)后再局部滴注Adr,可减轻Adr引起的微动脉收缩、流速减慢和流量减少,其作用优于罂粟碱。因此葛根素可改善实验性微循环障碍。     

大连市7～18岁学生1995-2005年肥胖流行情况分析：以皮褶厚度计算体脂含量

目的：采用皮褶厚度计算体脂含量的方法，了解大连学生超重和肥胖流行现状和流行趋势，为青少年生长发育研究、改善学生营养状况和制定学生肥胖防治措施提供依据。方法：①2005-05／06采用简单随机抽样原则，抽取大连市区的出生并生长的7-18岁汉族学生2474名，其中男生1244名，女生1230名。采用国际通用的人体测量学方法测量纳入学生的肱三头肌和肩胛下角部的皮褶厚度，并通过皮褶厚度推算体密度，计算全身体脂含量，再利用体脂含量判断肥胖并计算发生率。并将上述结果与1995年大连市内7-17岁汉族学生1190名和2000年大连市内7～18岁汉族学生1275名肥胖调查结果进行对比分析。②性别差异比较使用大样本的u检验。结果：2005年参与调查的2474名学生均进入结果分析。①学生体脂含量女生随年龄的增长而增加，男生则在11岁时达高峰后呈逐渐下降趋势，生长曲线男女无交叉现象。而且相同年龄段的体脂含量均是女生高于男生，并且除10-13岁年龄组外，其他年龄组差异均有显著性意义（u〉1．96，2．58，P〈0．05～0．01）。②与1995年调查结果比较，学生体脂含量10年来有较大程度增长，10年平均增长男女生分别为6．31％和4．47％。③学生2000年超重、轻度肥胖和中重度肥胖的发生率男生分别为14．3％，11．1％和7．9％，女生分别为11．0％，7．2％和2．8％。2005年超重、轻度肥胖和中重度肥胖的发生率男生分别为18．0％、11．6％和19．9％，女生分别为15．0％，10．2％和11．7％。结论：①2005年青春期后学生体脂含量有性别差异。②大连学生10年来体脂含量有较大程度的增长，并有继续增加的趋势。③大连学生5年间超重、轻度肥胖和中重度肥胖的发生率增加明显。     

超临界流体技术合成复合型骨替代生物材料的理化性质特点

目的:在复合材料理论基础上,将天然的皮质骨粉与聚乳酸混合,通过超临界流体合成技术,制备复合型骨组织替代支架材料,并评价其理化性质。方法:实验于2005-12/2006-04在暨南大学化学系实验室和南方医科大学生物力学实验时完成。①材料制备:将同种异体皮质骨粉与山东医疗器械研究所提供的聚乳酸按质量比0∶100,10∶90,20∶80,30∶70,40∶60分别混合后,在超临界CO2作用下复合成多孔骨生物替代材料。②材料的理化特征评价:对不同质量比的材料进行大体观察、生物力学检测,扫描电镜观察内部孔隙结构及检测孔径,乙醇排除法测量材料孔隙率,体外模拟降解检测pH值和质量的变化。结果:①表面形态观察:形状与铸模相同,表面可见均匀的孔隙结构,孔径适中,有较好的硬度。②生物力学实验结果:当骨粉含量为30%时,其抗压强度和压缩模量最高,分别为14.5 MPa,72.2 MPa,骨粉含量进一步提高时,复合材料的力学强度开始下降。③孔隙率:添加40%骨粉颗粒后,材料的孔隙率可由79%升至85.3%。④扫描电镜结果:不同材料的截面孔隙结构相似,孔径为50～200μm,孔隙连通性好。⑤体外降解pH值:复合材料最初2周pH值有所下降,但是2周后,可以稳定在pH值6.6左右,而含有40%骨粉的材料可以稳定在6.8左右。结论:应用超临界CO2技术合成的复合材料形状、大小、材料的孔隙可控,其孔隙率、生物力学强度、降解时间等理化性质方面良好,适合做为细胞工程支架和骨组织替代材料。     

Sporadic bilateral synchronous multicentric papillary renal cell carcinoma masquerading as bilateral multifocal pyelonephritis

Pyelonephritis is defined as an inflammation of the kidney and renal pelvis. The diagnosis is usually clinical. Acute multifocal bacterial nephritis is a rare form of pyelonephritis that is more severe and sepsis is more common. We report a patient who presented with fever and right-sided abdominal pain associated with right flank tenderness, suggesting right acute pyelonephritis. Bilateral multifocal pyelonephritis was diagnosed on ultrasonography, radionuclide renal scintigraphy and computed tomography. However, owing to non-resolution of symptoms, a biopsy was performed, which showed bilateral papillary renal cell carcinoma (PRCC). PRCC is known to exhibit multicentricity. To our knowledge, a case of bilateral multicentric PRCC masquerading as bilateral multifocal pyelonephritis has not been reported in the English literature. This case highlights the need to be vigilant while treating patients with focal lesions of the kidney as an inflammatory condition lest a malignancy should be missed.