全文获取类型
收费全文 | 293篇 |
免费 | 21篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 38篇 |
口腔科学 | 16篇 |
临床医学 | 14篇 |
内科学 | 101篇 |
皮肤病学 | 5篇 |
神经病学 | 21篇 |
特种医学 | 5篇 |
外科学 | 26篇 |
综合类 | 6篇 |
预防医学 | 18篇 |
眼科学 | 3篇 |
药学 | 20篇 |
中国医学 | 2篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 5篇 |
2022年 | 2篇 |
2021年 | 12篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 12篇 |
2017年 | 3篇 |
2016年 | 14篇 |
2015年 | 12篇 |
2014年 | 20篇 |
2013年 | 26篇 |
2012年 | 24篇 |
2011年 | 23篇 |
2010年 | 2篇 |
2009年 | 11篇 |
2008年 | 16篇 |
2007年 | 28篇 |
2006年 | 16篇 |
2005年 | 12篇 |
2004年 | 14篇 |
2003年 | 14篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1983年 | 1篇 |
1980年 | 2篇 |
排序方式: 共有315条查询结果,搜索用时 578 毫秒
61.
Sepici-Dincel A Sahin D Karasu Benli AC Sarikaya R Selvi M Erkoc F Altan N 《Toxicology mechanisms and methods》2011,21(5):388-392
The purpose of this study was to evaluate the adverse effects of sublethal doses of fenitrothion, an organophosphothionate insecticide on brain, gill, liver, and muscle tissues as a ratio of 8-OHdG to dG to indicate the DNA damage and erythrocyte micronucleus frequency for genotoxicity of carp (Cyprinus carpio L.) fingerlings. In our study, the mean weights and lengths of the fish (n?=?4-12) were 31.13?±?14.24?g and 12.53?±?1.41, respectively. Before the experiment, fish were maintained in aerated dechlorinated tap water at 21.8?±?1 °C and fed daily with commercial feed at a rate of 2% of their body weights. Experiments were conducted under static conditions in the aquaria. Technical grade (95%) fenitrothion was diluted in acetone to give a dosing solution of 10?mg/L. The increased lesions/10? DNA bases (p?0.05) of liver tissue of exposure group (0.49?±?0.18) was observed when compared to control group (0.28?±?0.30). There was not any significant differences between brain tissues, no damage were detectable in gill and muscle tissues of control groups, and in exposure groups altered levels of damage were detected for gill (0.06?±?0.05) and muscle (0.16?±?0.21) tissues. The increased micronucleus frequencies (%) in erythrocytes of carp following the exposure to 48?h fenitrothion (6.43?±?3.89; p<0.05) was observed when compared to control group (1.29?±?1.03). The available data indicate that there is still lack of well-established dose-response relationships between occupational or environmental exposures and the induction of 8-OHdG. Such biomarkers may be used in assessing adverse/toxic effects of pesticides as environmental stressors. 相似文献
62.
Ari H Celiloğlu N Ari S Coşar S Doganay K Bozat T 《Autonomic neuroscience : basic & clinical》2011,164(1-2):82-86
Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist. In this study, we assessed the effects of varenicline on heart rate variability (HRV). Thirty subjects were included in the randomized, double-blind, placebo-controlled, crossover study. Varenicline or placebo was administered in two different testing sessions. Time domain parameters and power spectral analysis of HRV were assessed in the supine position and during handgrip exercise before and after the participants were given placebo or varenicline. Fifteen healthy non-smokers (NS) and fifteen healthy smokers (S) were included in the study. There were no statistically significant differences among any of the time domain parameters obtained before and after placebo administration or between the S and NS groups with respect to varenicline administration. In frequency domain analyses, normalized HF (high-frequency) powers were significantly higher in the S group than in the NS group (before placebo, NS:6.57±3.58 vs. S:13.85±7.50, p=0.002, after placebo, NS:6.33±3.89 vs. S:10.82±4.88, p=0.007). After varenicline administration, the normalized HF power was significantly higher (NS:6.65±4.34 vs. S:11.06±4.52, p=0.01), and the ratio of LF (low-frequency) to HF was significantly lower (NS:8.44±5.89 vs. S:4.97±4.60, p=0.02) in the S group than in the NS group. Administration of a single dose of varenicline significantly increased the LF/HF ratio (5.83±2.69 vs. 8.44±5.89) in the NS group, but in the S group, there were no significant differences related to any of the time or frequency domain parameters. We concluded that a single dose of varenicline does not affect HRV in healthy smokers but that it may alter HRV when administered at a therapeutic dose to healthy non-smokers during mild sympathetic stimulation. 相似文献
63.
Selvi Rani D Vanniarajan A Gupta NJ Chakravarty B Singh L Thangaraj K 《Fertility and sterility》2006,86(6):1783-1785
We have analyzed the mitochondrial DNA of 34 oligoasthenozoospermic men along with 150 normozoospermic fertile men from the Indian subcontinent. A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men. 相似文献
64.
65.
66.
67.
68.
Omer Demirtas Levent Akman Gulsah Selvi Demirtas Behiye Seda Hursitoglu Huseyin Yilmaz 《Archives of gynecology and obstetrics》2013,287(3):519-523
Objective
To compare patients with tubo ovarian abscess (TOA) and non-TOA acute pelvic inflammatory disease (PID) and to determinate admitted day laboratory cut-off values for the TOA.Materials and methods
Files of inpatients admitted to our clinic with the diagnoses of PID and/or TOA between the years of 2006 and 2011. Laboratory and culture results were obtained from the database of hospital. A total of 73 patients diagnosed with PID and/or TOA were evaluated. Patients who were diagnosed with TOA and PID by physical and sonographic examination were assigned to group 1 and group 2, respectively. Both groups were compared in terms of laboratory, clinical, and epidemiological parameters.Results
Of 73 patients admitted with the diagnosis of PID, 44 (60.3 %) were found to have TOA, and 29 (39.7 %) were not found. Mean age of patients was determined as 41.4 ± 7.7 in group 1 and as 35.1 ± 6.8 in group 2. Abscess was detected more frequently in patients with low socio-cultural level, and this was found to be statistically significant. The diameter of abscess was found to be ≥5 cm in 39 (88.6 %) patients and <5 cm in 5 (11.4 %) patients. The average length of hospital stay was statistically significantly increased in patients with an abscess of ≥5 cm in size compared to patients with an abscess of <5 cm. When C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocyte counts were statistically evaluated by ROC curves, diagnostic ability of CRP, ESR and leukocyte count was found to be 73, 87, and 58 %. CRP has a specificity of 63 % and a sensitivity of 72 % if cut-off value is considered as 11.5 mg/L whereas ESR has a specificity of 83 % and a sensitivity of 79 % if cut-off value is considered as 19.5 mm/1/2 h.Conclusion
ESR >19.5 mm/1/2 h and CRP >11.5 mg/L were the best predictors of TOA. The high level of CRP and ESR was associated with longer duration of hospitalization and disease severity, and these levels were statistically significantly associated with TOA size of ≥5 cm. 相似文献69.
70.
Demiral AN Alicikus ZA Işil Ugur V Karadogan I Yöney A Andrieu MN Yalman D Pak Y Aksu G Ozyigit G Ozkan L Kilçiksiz S Koca S Caloğlu M Yavuz AA Başak Cağlar H Beyzadeoğlu M Iğdem S Serin M Kaplan B Koç M Korkmaz E Karakoyun-Celik O Dinçer S Kinay M 《International journal of radiation oncology, biology, physics》2008,72(5):1530-1537