全文获取类型
收费全文 | 594篇 |
免费 | 48篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 27篇 |
妇产科学 | 34篇 |
基础医学 | 59篇 |
口腔科学 | 26篇 |
临床医学 | 40篇 |
内科学 | 121篇 |
皮肤病学 | 8篇 |
神经病学 | 35篇 |
特种医学 | 31篇 |
外科学 | 138篇 |
综合类 | 5篇 |
预防医学 | 30篇 |
眼科学 | 4篇 |
药学 | 37篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 8篇 |
2022年 | 19篇 |
2021年 | 19篇 |
2020年 | 20篇 |
2019年 | 14篇 |
2018年 | 25篇 |
2017年 | 23篇 |
2016年 | 33篇 |
2015年 | 35篇 |
2014年 | 30篇 |
2013年 | 46篇 |
2012年 | 32篇 |
2011年 | 41篇 |
2010年 | 22篇 |
2009年 | 16篇 |
2008年 | 33篇 |
2007年 | 38篇 |
2006年 | 25篇 |
2005年 | 21篇 |
2004年 | 14篇 |
2003年 | 17篇 |
2002年 | 11篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 8篇 |
1986年 | 3篇 |
1985年 | 11篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有643条查询结果,搜索用时 15 毫秒
61.
62.
Sevgi Yetgin Deniz Aslan Sule Unal Betül Tavil Barış Kuşkonmaz Selin Aytaç Elmas 《Pediatric hematology and oncology》2013,30(6):492-501
Peripheral blood smears of 43 patients (26 males, median age 18 months, range: 6–180 months) with nutritional iron-deficiency anemia (IDA) were examined for the presence of trilineage hematological dysplasia. Twelve patients were reexamined for dysplastic findings after achieving a normal Hb and hematocrit level for age by the end of 2–3 months of iron treatment. A control group of 17 age-matched healthy children were also included. Neutrophils with loss of membrane entirety and protrusions were remarkable in 34/43 (79%) in the IDA group versus 1/12 (8%) after iron treatment and none of the control group. Microspherocytes were seen in 9/43 (21%) of IDA patients. Additionally, trilienage dysplasia was observed in the bone marrow samples available in 3 of the patients. It has been shown that iron-deficiency results in cellular DNA and RNA alterations, cell-cycle G1/S phase arrest, and apoptosis. Rac GTPases have been shown to control actin cytoskeleton, influencing cell polarity, microtubule dynamics, and the cytoskeletal organization of hematopoietic cells. Thus, the findings described above in neutrophils and red cells suggest a plausible link between iron and the Rac GTPase gene family. It may be a new avenue for iron waiting for proof. 相似文献
63.
Use of transcutaneous electrical nerve stimulation in the control of postoperative chest pain after cardiac surgery 总被引:1,自引:0,他引:1
O. Bayindir MD T. Paker MD B. Akpinar MD S. Erenturk MD D. Askin MD A. Aytac MD 《Journal of cardiothoracic and vascular anesthesia》1991,5(6):589-591
The effect of continuous transcutaneous electrical nerve stimulation (TENS) on postoperative pain following median sternotomy was evaluated in 89 patients with severe chest pain who underwent cardiac surgery in a prospective, randomized, blinded trial. Pain was assessed by visual analog pain scores before and during treatment in each group. In the active TENS group, 79% of the patients were completely free of chest pain during rest at the end of 180 minutes (P less than 0.001). Among the remaining patients with TENS, 16% had slight pain not needing narcotic analgesics and 5% still had chest pain requiring narcotics. In the control group in which inactive TENS was used, the intensity of pain was reduced in 44% of the patients at the end of 90 minutes (P less than 0.001). However, this early placebo effect was noted to diminish with time and at the end of 180 minutes, 80% of the patients complained of severe chest pain and needed narcotics. These data suggest that TENS can be effective in controlling postoperative chest pain due to median sternotomy after cardiac surgery and its continuous application in the early postoperative period can reduce the need for narcotics. 相似文献
64.
Kim SK Cornberg M Wang XZ Chen HD Selin LK Welsh RM 《The Journal of experimental medicine》2005,201(4):523-533
CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between lymphocytic choriomeningitis virus (LCMV) and Pichinde virus, where cross-reactive epitopes share six out of eight amino acids. Here, however, we demonstrate more subtle and less predictable cross-reactivity between LCMV and the unrelated vaccinia virus (VV). Epitope-specific T cell receptor usage differed between individual LCMV-infected C57BL/6 mice, even though the mice had similar epitope-specific T cell hierarchies. LCMV-immune mice challenged with VV showed variations, albeit in a distinct hierarchy, in proliferative expansions of and down-regulation of IL-7Ralpha by T cells specific to different LCMV epitopes. T cell responses to a VV-encoded epitope that is cross-reactive with LCMV fluctuated greatly in VV-infected LCMV-immune mice. Adoptive transfers of splenocytes from individual LCMV-immune donors resulted in nearly identical VV-induced responses in each of several recipients, but responses differed depending on the donor. This indicates that the specificities of T cell responses that are not shared between individuals may influence cross-reactivity with other antigens and play roles in heterologous immunity upon encounter with another pathogen. This variability in cross-reactive T cell expansion that is unique to the individual may underlie variation in the pathogenesis of infectious diseases. 相似文献
65.
Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner‐masked,randomized, controlled clinical trial
下载免费PDF全文
![点击此处可从《Journal of periodontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Selin Yıldırım Hafize Öztürk Özener Başak Doğan Bahar Kuru 《Journal of periodontology》2018,89(1):36-45
1 Background
This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery.2 Methods
Thirty‐six patients requiring FGG were randomly assigned into three groups in an examiner‐masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42.3 Results
Test groups experienced less pain than the control group on days 3 and 7 (P <0.001 and P <0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P <0.001 and P <0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively).4 Conclusion
Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match. 相似文献66.
67.
68.
Effects of Novel Finishing and Polishing Systems on Surface Roughness and Morphology of Nanocomposites
下载免费PDF全文
![点击此处可从《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》网站下载免费的PDF全文](/ch/ext_images/free.gif)
69.
Betul Tavil Mualla Cetin Murat Tuncer Fatma Gumruk Aysel Yuce Hulya Demir Selin Aytac Baris Kuskonmaz Sule Unal Sevgi Yetgin 《Hepatology research》2007,37(7):498-502
Aim: The aim of the study was to evaluate the rate of hepatitis B and C virus infection and emphasize the importance of hepatitis B virus (HBV) vaccination in leukemic children. Methods: One hundred and sixty children who were treated for acute lymphoblastic leukemia (ALL) at Hacettepe University Faculty of Medicine, Pediatric Hematology Unit were included in the study. They were 71 (44.4%) girls and 89 (55.6%) boys with a mean age of 6.45 +/- 3.87 years. Results: Of these 160 children, 22 (13.8%) were anti-HBs-positive and 138 (86.2%) were anti-HBs-negative at the diagnosis of ALL. Among the 138 anti-HBs-negative children, 67 (41.9%) were vaccinated for HBV during maintenance chemotherapy, and 71 (44.3%) could not be vaccinated. Two (2.9%) vaccinated and 22 (30.9%) unvaccinated children developed HBV infection during the follow-up period (P < 0.001). Among 160 children treated for ALL, 24 (15.0%) had HBV, three (1.9%) had hepatitis C virus (HCV) infections, and 29 (18.1%) had toxic hepatitis. The majority of patients with HBV or HCV infections had high risk (HR) protocol, whereas most of the patients with toxic hepatitis had low risk (LR) protocol, especially St Jude Total XIII LR protocol. Conclusion: Viral hepatitis and toxic hepatitis were observed more commonly in the HR and LR group, respectively, of ALL patients. This could be explained by intensive chemotherapy and more heavy blood product administration in the HR group and the chemotherapeutic agents of methotrexate and 6-mercaptopurine, basic drugs used in the LR group. In respect to protection from these complications, periodical liver function tests, serological tests for HBV and HCV, and vaccination for HBV should be performed for all children with ALL. 相似文献
70.
Carkaci S Adrada BE Rohren E Wei W Quraishi MA Mawlawi O Buchholz TA Yang W 《Academic radiology》2012,19(5):535-541