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101.
Purpose To investigate 2-year results of intravitreal triamcinolone acetonide injection for the treatment of diffuse diabetic macular
edema unresponsive to previous laser photocoagulation.
Method The study included 75 eyes of 75 diabetic patients with clinically significant diffuse macular edema that had failed to respond
to previous laser photocoagulation. An intravitreal injection of triamcinolone acetonide at the dose of 4 mg/0.1 ml was administered.
Best-corrected visual acuity was measured as the logarithm of the minimum angle of resolution (logMAR), and central macular
thickness was obtained by optical coherence tomography at each visit. Intraocular pressure and lenticular status were also
evaluated. Differences among measurements were evaluated by Friedman two-way analysis of variance by ranks. Mean follow-up
period was 24.7 ± 5.9 months.
Results The mean central macular thickness, which was obtained 3 days, 1 month, 3 months, 6 months, 9 months, 12 months, 18 months
and 24 months postoperatively, was significantly different from the baseline measurement (P < 0.001). Mean best-corrected logMAR visual acuity improved significantly from baseline at the 1- month and 3-month follow-up
intervals (P < 0.05), but there was no significant change at the 6- month, 9-month, 12-month, 18-month or 24-month follow-up periods (P > 0.05). During the follow-up, 29 (38.7%) eyes received re-injection of intravitreal triamcinolone. Twenty-one (28%) eyes
developed intraocular pressure values higher than 21 mmHg, and 18 (24%) eyes developed cataract. Thirteen (17.3%) eyes required
cataract and/or glaucoma surgery.
Conclusions In refractory diabetic macular edema, intravitreal triamcinolone effectively reduces foveal thickness and improves visual
acuity in the short term, but with the extended follow-up, the number of recurrences and steroid-related complications were
shown to increase. Nevertheless, it may be a therapeutic option in some patients that do not respond to previous laser photocoagulation. 相似文献
102.
Salih?Ta?k?n Yavuz?Emre??ükürEmail authorView authors OrcID profile Bulut?Varl? Kazibe?Koyuncu Mehmet?Murat?Seval Can?Ate? Selcen?Yüksel Mete?Güng?r F?rat?Orta? 《Archives of gynecology and obstetrics》2017,296(4):803-809
Purpose
To determine the clinical and pathological risk factors for lymph node metastasis (LNM) in patients with endometrial cancer and to create a nomogram to predict LNM in patients without surgical staging.Methods
All patients with endometrial adenocarcinoma who were treated surgically at a university based gynecologic oncology clinic between January 2011 and December 2014 were recruited. Women with endometrial adenocarcinoma who were surgically staged including lymphadenectomy were included in the study. Data regarding clinical and pathological risk factors were recorded. The histopathologic slides from the staging surgeries were re-evaluated microscopically by a gynecologic pathologist for all parameters along with lymphovascular space invasion (LVSI).Results
A total of 279 patients with endometrial cancer were analyzed. Among those, 31 (11.1%) had lymph node metastasis. According to the univariate analyses, elevated CA 125 (>35 U/mL), LVSI, myometrial invasion ≥50%, grade 3 disease, non-endometrioid type, and cervical stromal involvement were significantly associated with LNM. The multivariate logistic regression analysis showed that LVSI, non-endometrioid type, elevated CA 125, and cervical stromal involvement increased the risk of LNM. However, myometrial invasion and grade did not significantly affect the risk of LNM. A nomogram to predict LNM was constructed using these factors (concordance index 0.92).Conclusions
LVSI is the most important predictor for LNM. The present nomogram can be useful to decide if adjuvant therapy is required for patients who undergo simple hysterectomy for a benign etiology and incidentally diagnosed with endometrial cancer by pathological evaluation.103.
Risk factors associated with cardiovascular diseases in Turkey: Evidence from National Health Survey
Background
Cardiovascular diseases (CVDs), their causes and the precautions that can be taken have been studied by researchers from different fields and countries. Evidence from this wide literature suggest a close relationship between socio-economic factors and risk of CVDs.Objectives
The main aim of this study is to understand the main socio-economic determinants and risk factors associated with CVDs in Turkey.Methods
For such purpose, we perform a univariate logistic analysis using the 2016 Health Survey conducted by the Turkish Statistical Institute. Using this novel data set, we identify the risk factors of chronic heart disease with several demographic and socio-economic factors such as age, sex, education, income, alcohol and tobacco consumption, eating and exercise habits.Results
Our results indicate socio-economic status and demographic factors and individual characteristics are significant in terms of CVDs in Turkey. While socio-economic inequalities, baseline illnesses, and smoking are related with higher risk of CVDs, regular exercise, physical activity and moderate alcohol consumption are found to be related with lower risk of CVDs. Furthermore, gender plays an important and independent role on all socio-economic characteristics as well as any baseline illness.Conclusions
This study offers to fill the gap in the existing literature by offering a comprehensive analysis of socio-economic determinants and risk factors associated with CVDs in Turkey. Examining the risk factors for CVDs for all individuals and for men and women separately is informative to design policies in a more efficient way by addressing specific target groups. 相似文献104.
105.
The purpose of our study was to investigate the effects of L-carnitine on lipid peroxidation, Visual Evoked Potentials (VEPs) and antioxidant enzyme activities such as superoxide dismutase and catalase in rats exposed to chronic restraint stress. Forty male Wistar rats, aged three months were used. They were equally divided into four groups: control (C), the group exposed to restraint stress (R), the group treated with L-carnitine(L) and the group exposed to stress and treated with L-carnitine (RL). Chronic restraint stress was applied for 21 days (1 h/day) and L-carnitine (50 mg/kg/day) was given by gavage to the L and RL groups for the same period.Brain and retina levels of thiobarbituric acid reactive substances (TBARS) were significantly increased in the R group and were not altered in the L group compared to the C group. Brain and retina TBARS levels were lower in the RL group than in the R group. Brain and retina superoxide dismutase and catalase activities were significantly decreased in the L and R groups compared to the C group. L-carnitine pretreatment had no significant effect on superoxide dismutase and catalase activity in the RL group. All latencies of VEP components were prolonged in the R and L groups with respect to the C group. L-carnitine increased the latencies of all VEP components in the L group whereas shortened them in the RL group compared to their control groups. L-carnitine may be a promising agent for the prevention of VEP and TBARS alterations caused by stress. 相似文献
106.
107.
Ata Türker Arıkök Evrim Önder Hakan Seçkin Ayper Kaçar Ramazan Fesli Ayşe Selcen Oğuz Murat Alper 《Brain tumor pathology》2014,31(2):94-100
Recurrence of meningiomas is a major prognostic issue. Although World Health Organization (WHO) histopathological grading correlates strongly with recurrence, it has some limitations, and predicting the biological behavior of grade I meningiomas is particularly difficult. Osteopontin (OPN) is a protein known to be involved in tumor progression. The purpose of this study is to determine expression of OPN in meningiomas and to investigate its correlation with WHO grades and tumor recurrence. Immunohistochemical (IHC) evaluation of expression of OPN was performed by two different methods to ensure reliability. OPN IHC and Allred scores were calculated on the basis of intensity and extent of staining. Both scores were in agreement and correlated significantly with meningioma grade and Ki-67 index. OPN scores were also significantly correlated with recurrence of WHO grade I meningiomas. Cut-off values for OPN IHC and OPN Allred scores between non-recurrent and recurrent grade I meningiomas were calculated as 70 and 5.5 respectively. We concluded that OPN is a valuable marker for grading meningiomas and for predicting the recurrence in WHO grade I tumors. 相似文献
108.
Murat Sunbul Esra Aydin Sunbul Selcen Dogru Kosker Erdal Durmus Tarik Kivrak Cigdem Ileri 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2014,36(5):354-358
Background: Previous studies have shown that depression and anxiety were independent risk factors for hypertension. Non-dipper hypertension is associated with higher cardiovascular mortality. The aim of this study was to evaluate the anxiety and depression scores in patients with dipper and non-dipper hypertension. Methods: The study sample consisted of 153 hypertensive patients. All patients underwent 24-h blood pressure monitoring. Patients were classified into two groups according to their dipper or non-dipper hypertension status. We evaluated results of the Hospital Anxiety and Depression Scale between groups. Results: Seventy-eight patients (38 male, mean age: 51.6?±?12.5 years) had dipper hypertension while 75 patients (27 male, mean age: 55.4?±?14.1 years) had non-dipper hypertension (p?=?0.141, 0.072, respectively). Clinical characteristics were similar for both groups. Patients with non-dipper hypertension had significantly higher depression and anxiety scores compared to patients with dipper hypertension. Dipper and non-dipper status significantly correlated with anxiety (p: 0.025, r: 0.181) and depression score (p: 0.001, r: 0.255). In univariate analysis, smoking, alcohol usage, presence of diabetes, hyperlipidemia, anxiety score >8 and depression score >7 were predictors of dipper versus non-dipper status. In multivariate logistic regression analyses only depression score >7 was independent predictor of dipper versus non-dipper status (odds ratio: 2.74, confidence intervals: 1.41–5.37). A depression score of 7 or higher predicted non-dipper status with a sensitivity of 62.7% and specificity of 62.8%. Conclusion: Non-dipper patients have significantly higher anxiety and depression scores compared to dipper patients. Evaluation of anxiety and depression in patients with hypertension might help to detect non-dipper group and hence guide for better management. 相似文献
109.
110.