A cross-sectional study about the relationship between morphology and kinematic parameters in children between 15 and 36 months

Morphology and kinematic parameters were recorded for 31 children between 15 and 36 months to investigate the relation between morphology and the walking pattern. A full 3D gait analysis using a VICON motion system was performed to gather kinematic data. Next, the differences in kinematic parameters between four morphological classes were assigned with a multiple analysis of variance, with a correction for walking experience. Also stepwise linear regressions were performed, to examine the relation between detailed morphological measurements and kinematic parameters. The regression models showed relationships between kinematic parameters of the ankle, hip, thorax and morphology. All results indicated that the upper body played an important role in the coordination of the walking pattern, especially in the frontal plane.     

Kinematics of the transition between walking and running when gradually changing speed

The purpose of this study was to examine kinematics of the walk-to-run transition (WRT) and run-to-walk transition (RWT) when speed is altered with a constant acceleration of 0.1 m s(-2), respectively -0.1 m s(-2). Thirteen women (height: 168.9+/-3.36 cm) performed gait transitions on a motor-driven treadmill. WRT-speed was 2.16+/-0.12 m s(-1), RWT-speed 2.19+/-0.12 m s(-1). Kinematics were examined in the range from eight steps before to eight steps after transition in order to identify the possible occurrence of a transition process to facilitate the actual realization of transition. A transition step in which the main changes from one gait to another are realized is present in WRT and RWT. Despite this clear discontinuity, a transition process also appeared in both transitions. In the WRT, transition was prepared and kinematic adaptations were found in the last swing before transition leading to altered landing conditions. During RWT posttransition changes were observed and RWT was only completed after reorientation of the trunk in the first walking stride after transition. A noteworthy finding was that spatiotemporal (presence of a flight phase), kinematic (knee flexion) and energetic (kinetic and gravitational potential energy fluctuating in-phase versus out-of-phase) criteria to define transition stride correspond to each other. Furthermore, a functional interlimb asymmetry was recognized as a unique characteristic of the transition stride, offering a fourth way of identifying the transition stride.     

Neural evidence of allophonic perception in children at risk for dyslexia

Learning to read is a complex process that develops normally in the majority of children and requires the mapping of graphemes to their corresponding phonemes. Problems with the mapping process nevertheless occur in about 5% of the population and are typically attributed to poor phonological representations, which are – in turn – attributed to underlying speech processing difficulties. We examined auditory discrimination of speech sounds in 6-year-old beginning readers with a familial risk of dyslexia (n=31) and no such risk (n=30) using the mismatch negativity (MMN). MMNs were recorded for stimuli belonging to either the same phoneme category (acoustic variants of /b?/) or different phoneme categories (/b?/ vs. /d?/). Stimuli from different phoneme categories elicited MMNs in both the control and at-risk children, but the MMN amplitude was clearly lower in the at-risk children. In contrast, the stimuli from the same phoneme category elicited an MMN in only the children at risk for dyslexia. These results show children at risk for dyslexia to be sensitive to acoustic properties that are irrelevant in their language. Our findings thus suggest a possible cause of dyslexia in that they show 6-year-old beginning readers with at least one parent diagnosed with dyslexia to have a neural sensitivity to speech contrasts that are irrelevant in the ambient language. This sensitivity clearly hampers the development of stable phonological representations and thus leads to significant reading impairment later in life.     

Novel SACS mutation in a Belgian family with sacsin-related ataxia

The authors describe the four patients in the first known Belgian family with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). A novel homozygous missense mutation, NM_014363.3: c.3491T>A in exon 9, of the SACS gene was identified in the present family, which results in an original amino acid of methionine to lysine substitution at amino acid residue 1164 (p.M1164K). Although the cardinal clinical features, i.e., spastic ataxia with peripheral neuropathy, in our patients were similar to those in Quebec patients, our patients exhibited some atypical clinical features, e.g., teenage-onset and absence of retinal hypermyelination. The present family is from Wallonia, and there could be shared ethnicity with the families of Charlevoix-Saguenay.