全文获取类型
收费全文 | 2156篇 |
免费 | 115篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 69篇 |
妇产科学 | 34篇 |
基础医学 | 184篇 |
口腔科学 | 40篇 |
临床医学 | 173篇 |
内科学 | 436篇 |
皮肤病学 | 62篇 |
神经病学 | 137篇 |
特种医学 | 303篇 |
外科学 | 321篇 |
综合类 | 53篇 |
一般理论 | 2篇 |
预防医学 | 99篇 |
眼科学 | 66篇 |
药学 | 154篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 11篇 |
2022年 | 21篇 |
2021年 | 49篇 |
2020年 | 28篇 |
2019年 | 49篇 |
2018年 | 44篇 |
2017年 | 38篇 |
2016年 | 36篇 |
2015年 | 56篇 |
2014年 | 68篇 |
2013年 | 99篇 |
2012年 | 129篇 |
2011年 | 126篇 |
2010年 | 86篇 |
2009年 | 72篇 |
2008年 | 90篇 |
2007年 | 83篇 |
2006年 | 81篇 |
2005年 | 85篇 |
2004年 | 79篇 |
2003年 | 67篇 |
2002年 | 55篇 |
2001年 | 35篇 |
2000年 | 38篇 |
1999年 | 26篇 |
1998年 | 44篇 |
1997年 | 40篇 |
1996年 | 44篇 |
1995年 | 50篇 |
1994年 | 39篇 |
1993年 | 41篇 |
1992年 | 34篇 |
1991年 | 21篇 |
1990年 | 25篇 |
1989年 | 50篇 |
1988年 | 32篇 |
1987年 | 39篇 |
1986年 | 41篇 |
1985年 | 23篇 |
1984年 | 18篇 |
1983年 | 15篇 |
1982年 | 15篇 |
1981年 | 19篇 |
1980年 | 21篇 |
1979年 | 10篇 |
1978年 | 17篇 |
1977年 | 23篇 |
1976年 | 16篇 |
1975年 | 16篇 |
1957年 | 6篇 |
排序方式: 共有2283条查询结果,搜索用时 0 毫秒
51.
Hui Hua Chang Mei Hung Chi I Hui Lee Hsin Chun Tsai Po Wu Gean Yen Kuang Yang Ru-Band Lu Po See Chen 《Journal of affective disorders》2013
Background
A reciprocal relationship between diabetes risk and depression has been reported. There are few studies investigating glucose–insulin homeostasis before and after short-term antidepressant treatment in drug-naïve major depressive disorder (MDD) patients.Methods
This study included 104 healthy controls and 50 drug-naïve MDD patients diagnosed according to the DSM-IV criteria. These MDD patients were randomly assigned to receive fluoxetine or venlafaxine for six weeks. Depressive symptoms, body mass index, fasting plasma levels of glucose and insulin were measured.Results
Compared to the healthy controls, the fasting plasma insulin and the homeostasis model of assessment for pancreatic β-cell secretory function (HOMA-β) was significantly lower in the MDD patients before antidepressant treatment (7.7±4.8 μIU/mL vs. 5.1±4.2 μIU/mL, p=0.006; 114.2±72.3% vs. 74.8±52.0%, p=0.005, respectively). However, these indices were not correlated with depression severity. After 6 weeks of fluoxetine or venlafaxine treatment, the level of HOMA-β borderline significantly increased (108.1±75.5%, p=0.059).Limitations
The study was limited by the follow-up duration and lack of a placebo group.Conclusions
Antidepressants might affect insulin secretion independently of the therapeutic effects on MDD. Further studies are needed to investigate the long-term effects of antidepressants on insulin regulation in MDD patients. 相似文献52.
53.
Craig W. See Kieran S. O'Brien Jeremy D. Keenan Nicole E. Stoller Bruce D. Gaynor Travis C. Porco Thomas M. Lietman 《The American journal of tropical medicine and hygiene》2015,93(5):1106-1109
A cluster-randomized trial demonstrated that mass oral azithromycin distribution reduced childhood mortality 49.6% (Trachoma Amelioration in Northern Amhara [TANA]). The relative risk of childhood mortality was then estimated using two approaches: an expert survey and a Bayesian analysis. The survey asked public health experts to estimate the true effect of mass azithromycin distribution on childhood mortality. The Bayesian estimation used the TANA study''s results and prior estimates of the efficacy of other effective population-level interventions. The experts believed mass azithromycin reduces childhood mortality (relative risk = 0.83, 95% credible intervals [CrI] = 0.70–1.00). The Bayesian analysis estimated a relative risk of 0.71 (95% CrI = 0.39–0.93). Both estimates suggest that azithromycin may have a true mortality benefit, though of a smaller magnitude than found in the single available trial. Prior information about nonantibiotic, population-level interventions may have informed the expert''s opinions. Additional trials are needed to confirm a mortality benefit from mass azithromycin. 相似文献
54.
Xiayan Shen Benjamin Wei Rong Tay Benjamin Yong-Qiang Tan Nicholas Jinghao Ngiam John Shao Rong Mok Shao Feng Mok Eng Soo Yap See Meng Khoo 《Singapore medical journal》2020,61(1):34
INTRODUCTIONNear-peer teaching is gaining popularity as a teaching modality, as it improves the learner’s understanding, is targeted at an appropriate level and promotes familiarisation. This study was initiated to evaluate the effectiveness of incorporating near-peer instruction into simulation-based training within a junior residency programme.METHODS42 first-year residents from an internal medicine junior residency programme were recruited. Participants underwent a simulation-based training programme conducted over five weeks. Each week involved either an emergency or acute clinical scenario. A structured questionnaire was administered prior to and after the course to compare participants’ perceived knowledge, experience and confidence in managing the clinical scenarios.RESULTSIn our study, 83% of participants agreed/strongly agreed that the scenarios were realistic. There were improvements in perceived knowledge, experience and confidence after the course. The greatest improvement was seen for experience (post-simulation: median 7.00 [interquartile range (IQR) 6.00‒8.00] vs. pre-simulation: median 5.00 [IQR 3.00–6.25]). 65% of participants were keen to help with future training.CONCLUSIONNear-peer simulation training was found to be a viable and valuable method of instruction for first-year residents for increasing experience, instilling confidence and improving perceived knowledge. Integration of such programmes within medical education curricula shows good promise of continuity, with many first-year residents inspired to organise subsequent sessions. 相似文献
55.
56.
57.
Jeremy Yuen Chun Teoh Ning Hong Chan Ho Yuen Cheung Simon See Ming Hou Chi-Fai Ng 《International urology and nephrology》2013,45(4):975-977
We report a case of a 60-year-old woman who had a delayed presentation of duodenal obstruction as a result of a bleeding right renal angiomyolipoma (AML) with retroperitoneal hematoma. Her duodenal obstruction did not improve upon conservative management, and a computed tomography (CT)-guided drainage of the retroperitoneal hematoma was subsequently performed. Post-intervention, CT scan confirmed hematoma resolution, and she was able to resume normal diet afterwards. We present this first reported case of a bleeding renal AML with retroperitoneal hematoma causing duodenal obstruction and discuss on the management of such condition. 相似文献
58.
59.
The Milan criteria have been proven to be reliable and easily applicable in selection of patients with small unresectable hepatocellular carcinomas for liver transplantation. It has been repeatedly shown that patients who met these criteria had a 5-year survival of over 70% after transplantation. Such a result is remarkably good for an otherwise incurable malignancy. The main disadvantage of this set of criteria is that it is rather restrictive. Following it religiously denies transplantation to many patients who have tumor stage slightly more advanced.There have been many attempts to extend the criteria to include tumors with larger sizes (as in the UCSF criteria) or with a larger number (as in the Kyoto criteria). Alpha-fetoprotein and PIVKA-II, two biological markers in more aggressive tumors, have also been employed in the selection of patients, and biopsies have been used by the University of Toronto to determine tumor aggressiveness before deciding on transplantation. Patients with tumors beyond the Milan criteria yet not of a high grade have been accepted for transplantation and their survival is comparable to that of transplant recipients who were within the Milan criteria. Preoperative dual-tracer (11C-acetate and FDG) positron emission tomography has been used to determine tumor grade, and transarterial chemoembolization has been used to downstage tumors, rendering them meeting the Milan criteria. Patients with downstaged tumors have excellent survival after transplantation. Partial response to chemical treatment is a reflection of less aggressive tumor behavior.Careful selection of patients beyond the Milan criteria with the aid of serum tumor marker assay, positron emission tomography or tumor biopsy allows transplanting more patients without compromising survival. The use of liver grafts either from the deceased or from living donors could thus be justified.Key Words: Hepatocellular carcinoma, liver transplantation, Milan 相似文献
60.
Tzu I Lee Joana Issac Shih-Hsien Lin Tzung Lieh Yeh I. Hui Lee Po See Chen Kao Chin Chen Yen Kuang Yang 《General hospital psychiatry》2013