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51.
Joaquin Calatayud Sebastien Borreani Juan C. Colado Fernando F Martín Michael E. Rogers David G. Behm Lars L. Andersen 《Journal of Sports Science and Medicine》2014,13(3):502-510
The purpose of this study was to analyze upper extremity and core muscle activation when performing push-ups with different suspension devices. Young fit male university students (n = 29) performed 3 push-ups each with 4 different suspension systems. Push-up speed was controlled using a metronome and testing order was randomized. Average amplitude of the electromyographic root mean square of Triceps Brachii, Upper Trapezius, Anterior Deltoid, Clavicular Pectoralis, Rectus Abdominis, Rectus Femoris, and Lumbar Erector Spinae was recorded. Electromyographic signals were normalized to the maximum voluntary isometric contraction (MVIC). Electromyographic data were analyzed with repeated-measures analysis of variance with a Bonferroni post hoc. Based upon global arithmetic mean of all muscles analyzed, the suspended push-up with a pulley system provided the greatest activity (37.76% of MVIC; p < 0.001). Individually, the suspended push-up with a pulley system also provided the greatest triceps brachii, upper trapezius, rectus femoris and erector lumbar spinae muscle activation. In contrast, more stable conditions seem more appropriate for pectoralis major and anterior deltoid muscles. Independent of the type of design, all suspension systems were especially effective training tools for reaching high levels of rectus abdominis activation.
Key Points
- Compared with standard push-ups on the floor, suspended push-ups increase core muscle activation.
- A one-anchor system with a pulley is the best option to increase TRICEP, TRAPS, LUMB and FEM muscle activity.
- More stable conditions such as the standard push-up or a parallel band system provide greater increases in DELT and PEC muscle activation.
- A suspended push-up is an effective method to achieve high muscle activity levels in the ABS.
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53.
Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study 下载免费PDF全文
Guillaume de Bonnecaze MD MSc Benjamin Verillaud MD PhD Leonor Chaltiel PhD Sylvestre Fierens MD Mark Chapelier MD Cécile Rumeau MD MSc Olivier Malard MD PhD Marie Gavid MD MSC Xavier Dufour MD PhD Christian Righini MD PhD Emmanuelle Uro‐coste MD PhD Michel Rives MD Christine Bach MD Bertrand Baujat MD PhD François Janot MD PhD Ludovic de Gabory MD PhD Sebastien Vergez MD PhD 《International forum of allergy & rhinology》2018,8(9):1065-1072
Background
Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management.Methods
A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors.Results
Definitive analyses focused on 54 patients with a majority of advanced stage; the 3‐year overall survival (OS) and 3‐year recurrence‐free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow‐up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph‐node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity‐modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS.Conclusion
Multimodal therapies including induction chemotherapy and intensity‐modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.54.
Iris Schuster Gilbert Habib Christophe Jego Franck Thuny Jean-Fran?ois Avierinos Geneviève Derumeaux Lionel Beck Christine Medail Frederic Franceschi Sebastien Renard Ange Ferracci Jean Lefevre Roger Luccioni Jean-Claude Deharo Pierre Djiane 《Journal of the American College of Cardiology》2005,46(12):2250-2257
OBJECTIVES: To compare the incidence of diastolic and systolic asynchrony, assessed by tissue Doppler imaging (TDI), in patients with congestive heart failure (CHF) and severe left ventricular (LV) dysfunction, and to assess TDI changes induced by cardiac resynchronization therapy (CRT). BACKGROUND: Thirty percent of CRT candidates are nonresponders. Besides QRS width, the presence of echographic systolic asynchrony has been used to identify future responders. Little is known about diastolic asynchrony and its change after CRT. METHODS: Tissue Doppler imaging was performed in 116 CHF patients (LV ejection fraction 26 +/- 8%). Systolic and diastolic asynchrony was calculated using TDI recordings of right ventricular and LV walls. RESULTS: The CHF group consisted of 116 patients. Diastolic asynchrony was more frequent than systolic, concerning both intraventricular (58% vs. 47%; p = 0.0004) and interventricular (72 vs. 45%; p < 0.0001) asynchrony. Systolic and diastolic asynchrony were both present in 41% patients, but one-third had isolated diastolic asynchrony. Although diastolic delays increased with QRS duration, 42% patients with narrow QRS presented with diastolic asynchrony. Conversely, 27% patients with large QRS had no diastolic asynchrony. Forty-two patients underwent CRT. Incidence of systolic intraventricular asynchrony decreased from 71% to 33% after CRT (p < 0.0001), but diastolic asynchrony decreased only from 81% to 55% (p < 0.0002). Cardiac resynchronization therapy induced new diastolic asynchrony in eight patients. CONCLUSIONS: Diastolic asynchrony is weakly correlated with QRS duration, is more frequent than systolic asynchrony, and may be observed alone. Diastolic asynchrony is less improved by CRT than systolic. Persistent diastolic asynchrony may explain some cases of lack of improvement after CRT despite good systolic resynchronization. 相似文献
55.
Prevalence of hepatitis C virus infection in asymptomatic anti-HIV1 negative pregnant women and their children 总被引:1,自引:0,他引:1
Dr. Patrick Marcellin MD Jacques Bernuau MD Michèle Martinot-Peignoux BS Daniel Larzul PhD Li-Zhe Xu BS Sebastien Tran MD Annie Bezeaud MD PhD Marie-Christine Guimont PharmD Michel Levardon MD Pascale Aumont PhD Serge Erlinger MD Jean-Pierre Benhamou MD 《Digestive diseases and sciences》1993,38(12):2151-2155
The prevalence of hepatitis C virus (HCV) infection was studied prospectively in pregnant women in France and their children by detection of anti-HCV with second-generation ELISA (ELISA2). In ELISA2-positive women, anti-HCV was detected with second- and third-generation RIBA (RIBA2 and RIBA3) and serum HCV RNA was detected with PCR. Among 670 women, anti-HIV1-negative, 26 (3.9%) were positive with ELISA2. RIBA2 was positive in 13 and HCV RNA was found in 10. Ten ELISA2-positive women had a further evaluation with assessment of HCV infection in their children. Among the 10 children born to the index pregnancy, only one was positive with ELISA2 and RIBA2 but negative with RIBA3 and PCR; the nine other children were ELISA2, RIBA2, RIBA3, and PCR negative. All 26 siblings (2–16 years old), of whom 14 were born to PCR-positive mothers, were ELISA2 and RIBA2 negative. We conclude that among anti-HIV1-negative pregnant women with normal serum ALT levels, the prevalence of HCV infection is relatively high but the risk for mother-to-infant transmission of HCV seems to be low. 相似文献
56.
57.
Madina Agénor Nancy Krieger S. Bryn Austin Sebastien Haneuse Barbara R. Gottlieb 《American journal of public health》2014,104(2):e68-e73
We investigated sexual orientation disparities in Papanicolaou screening among US women aged 21 to 44 years (n = 9581) in the 2006 to 2010 National Survey of Family Growth. The odds ratios for lesbian versus heterosexual women and women with no versus only male sexual partners were 0.40 and 0.32, respectively, and were attenuated after adjustment for sexual and reproductive health (SRH) care indicators. Administering Papanicolaou tests through mechanisms other than SRH services would promote cervical cancer screening among all women.Cervical cancer, a deadly disease primarily caused by human papillomavirus infection,1 can be prevented through regular Papanicolaou (Pap) test use and appropriate follow-up.2,3 Although lesbians and women who have sex with women are at risk for human papillomavirus4–14 from both past and present sexual partners, limited evidence derived from convenience15,16 and subnational population-based16,17 samples suggests that they are less likely than heterosexual women and women with only male sexual partners, respectively, to receive Pap tests.8,9,15,17–22 We accordingly investigated sexual orientation disparities in Pap test use in a large US national probability sample, which no previous study has done, and assessed the contribution of sexual and reproductive health (SRH) services to sexual orientation disparities in Pap test use. 相似文献
58.
Guillaume Fond Anderson Loundou Sebastien Guillaume Xavier Quantin Alexandra Macgregor Régis Lopez Philippe Courtet Paquito Bernard Daniel Bailly Mocrane Abbar Marion Leboyer Laurent Boyer 《European archives of psychiatry and clinical neuroscience》2014,264(5):379-389
It is unclear whether adult smokers with childhood attention-deficit/hyperactivity disorder history (CH) have more severe smoking behavior than non-CH smokers, while it is clearly suggested that CH adolescents have more severe smoking behavior than CH adolescents. The aim of the present comprehensive meta-analysis is to determine whether CH smokers have more severe smoking behavior characteristics than those without and the effect of age on the association between CH and smoking behavior. We included all case–control studies and first round data collection of observational studies addressing the difference in smoking behavior characteristics of CH smokers versus non-CH smokers, with validated scales or structured interviews, without any language or date restriction. Nine studies (including 365 smokers with CH and 1,708 smokers without) were included. Compared to non-CH smokers, CH smokers smoked significantly more cigarettes [standardized mean differences (SMD) = 0.15, 95 % CI 0.01–0.28, p = 0.04] and began to regularly smoke earlier (SMD = ?0.28, 95 % CI ?0.49; ?0.07, p = 0.01) but were not significantly more nicotine dependent (SMD = 0.23, 95 % CI ?0.04 to 0.48, p = 0.08). After removing the single adolescent study, the significant association between CH and number of daily smoked cigarettes disappeared, and subgroups analyses confirmed that the significant association between CH and number of daily smoked cigarettes disappeared as age increased. Our meta-analysis illustrates a clinically important link between CH and tobacco smoking in adolescence but not later in life. Further high-quality studies are needed to confirm this finding, as only two studies included participants with a mean age below 20 years. 相似文献
59.
Mycobacterium bovis bacillus Calmette-Guerin (BCG), the only vaccine currently used against tuberculosis, is an attenuated derivative of M. bovis that has been propagated in vitro for more than 40 years. We have previously reported that the experimentally-verified human T cell epitopes of the M. tuberculosis complex (MTBC) are the most conserved elements of the genome; whether immune recognition is the force driving the conservation of epitopes in the MTBC is unknown. Therefore, we sequenced the genomes of 12 BCG strains to determine whether T cell epitopes were under selection pressure during BCG in vitro evolution. We constructed a genome-wide phylogeny and refined the previously-determined BCG phylogeny. Notably, we identified a new cluster between BCG Japan and BCG Russia, and repositioned the relationships of several strains within the lineage. We also compared the sequence diversity of 1530 experimentally verified human T cell epitopes in the BCG vaccines with those in the MTBC. We found 23% of the known T cell epitopes are absent, and that the majority (82%) of the absent epitopes in BCG are contained in 6 proteins encoded in 2 regions of difference (RD) unique to BCG strains. We also found that T cell epitope sequences in BCG are more conserved than non-epitope sequences in the same gene. Finally, we find evidence that epitope sequence variation in BCG potentially affects human T cell recognition. These findings provide new insight into sequence variation in a slow-growing bacterium closely related to the MTBC that has been subjected to prolonged passage outside of a mammalian host, and indicate little difference in the extent of variation in vivo and in vitro. 相似文献
60.
Differential impairments underlying decision making in anorexia nervosa and bulimia nervosa: A cognitive modeling analysis 下载免费PDF全文