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101.
102.
SW Hong J Lee SE Park EJ Rhee CY Park KW Oh SW Park WY Lee 《Molecular and cellular endocrinology》2012,362(1-2):242-252
Exendin-4 (Ex-4), a long-acting agonist of glucagon-like peptide-1 receptor, is a novel anti-diabetic drug that prevents β-cells against various toxicities. However, the mechanism and molecules mediating the protection procession of Ex-4 are not fully understood. We investigated the protective effect of Ex-4 against lipotoxicity, mediated by a repression of sterol regulatory element-binding protein (SREBP)-1c, a regulator of genes expression involved in fat and cholesterol synthesis. To observe the effect of Ex-4, we evaluated glucose-stimulated insulin secretion (GSIS) and apoptosis in the MIN6 pancreatic β-cell line, which were cultured in DMEM medium containing 500μM palmitate, with or without 10nM Ex-4. We also examined the roles of SREBP-1c in lipotoxicity model by knockdown with si-RNA. Treatment with Ex-4 improved insulin secretion and survival as well as reduced SREBP-1c expression and activity in palmitate-treated MIN6 cells. This improvement was accompanied with an upregulation of PI3K/Akt signaling pathway, and LY294.002, a specific inhibitor of PI3 kinase, abrogated effects of Ex-4 on insulin secretion. Moreover, SREBP-1c in nuclei was increased by the inhibition of PI3 kinase. Lipotoxic effects of palmitate in the insulin secretion and apoptosis were significantly prevented by SREBP-1 knockdown. In conclusion, Ex-4 protects β-cell against palmitate-induced β-cell dysfunction and apoptosis, by inhibiting SREBP-1c expression and activity through the PI3K/Akt signaling pathway. 相似文献
103.
104.
Se‐Won Lim Juwon Ha Young‐Chul Shin Dong‐Won Shin Seung‐Min Bae Kang‐Seob Oh 《Early intervention in psychiatry》2013,7(1):44-50
Aim: The aim of this study was to elucidate the clinical differences between early‐ and late‐onset social anxiety disorder (SAD) in the Korean population. Methods: Three hundred and eighty‐seven outpatients diagnosed with SAD participated in this study. Confirmation of SAD diagnosis was based on the Mini International Neuropsychiatric Interview. All subjects completed the Liebowitz Social Anxiety Scale and anxiety‐trait‐related scales such as the Anxiety Sensitivity Index, Retrospective Self‐Report of Inhibition, Trait Form of the State‐Trait Anxiety Inventory, and Beck Depression Inventory. Results: The early‐onset group (n = 209) consisted of subjects aged up to 18 years at the time of onset, whereas the late‐onset group (n = 178) consisted of subjects older than 18 years at the time of onset. Early‐onset SAD patients were more likely to have the generalized subtype and to visit clinics with chief complaints other than social anxiety symptoms. They exhibited more severe symptoms and higher behavioural inhibitions. After adjusting for age and symptom severity, behavioural inhibition was the only significant difference between the two groups. The degree of behavioural inhibitions was associated with earlier onset age. Conclusion: Symptom severity and behavioural inhibitions, especially in social/school situations, were clinical characteristics that differentiated between early‐ and late‐onset SAD. 相似文献
105.
In evaluating cervical lymph node (LN) metastasis from papillary thyroid cancer (PTC), ultrasonography (US)-guided fine-needle aspiration biopsy (FNAB) is very important tool. There were limited number of studies about the diagnostic value of thyroglubion measurement in FNAB (FNAB-Tg) in non-thyroidectomized patients. Therefore, in this study, the authors evaluated the role of FNAB-Tg in diagnosing cervical LN metastases in patients with PTC before thyroidectomy. A total 91 suspicious LNs of 68 patients were undergone US-guided FNAB-Tg and cytology. Any FNAB-Tg concentration above 50?ng/ml considered as positive, irrespective of thyroid gland presence. Based on the final pathology, 49 LNs were positive, and the remaining 42 LNs were negative for metastasis. The sensitivity, specificity, and accuracy of FNAB-Tg in thyroidectomized patients were 80.0, 100.0, and 88.9%, respectively. The diagnostic performance of FNAB-Tg was not compromised by the presence of thyroid gland (sensitivity, specificity and accuracy?=?95.0, 90.9 and 93.2%, respectively). FNAB-Tg is useful and simple method for the diagnosis of metastatic cervical LNs from PTC. The diagnostic performance of FNAB-Tg was not compromised by the presence of thyroid gland. Therefore, FNAB-Tg could be performed actively for the LN staging of PTC. 相似文献
106.
Hyeong Kug KimYu Jeong Choi MD Ki-Woon KangJin A. Lee MD Se Young ParkSeok-Jae Zeon MD Sang Hyun ParkWon Ho Kim MD Sahng LeeKyung Tae Jung MD Soon Chang Park MD 《The Canadian journal of cardiology》2012
Coronary artery anomalies in patients undergoing coronary angiography are often technically challenging for invasive cardiologists and may delay revascularization time. We report a patient who underwent successful bailout revascularization using dual-source computed tomography after failed emergency angiography. This case emphasizes the utility of dual-source computed tomography, especially in an urgent clinical setting, for allowing interventional cardiologists to rapidly identify and effectively treat the aberrant coronary artery. 相似文献
107.
108.
Lee BI Hong SP Kim SE Kim SH Kim HS Hong SN Yang DH Shin SJ Lee SH Kim YH Park DI Kim HJ Yang SK Kim HJ Jeon HJ;Multi-Society Task Force for Development of Guidelines for Colorectal Polyp Screening Surveillance Management 《Taehan Sohwagi Hakhoe chi》2012,59(2):65-84
Colorectal cancer is the second most common cancer in males and the fourth most common in females in Korea. Since the most of colorectal cancer occur through the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are one of the most effective methods to prevent colorectal cancer. Considering the increasing incidence of colorectal cancer and polyps in Korea, it is very important to establish Korean guideline for colorectal cancer screening and polyp detection. Korean Multi-Society Take Force developed the guidelines with evidence-based methods. Parts of the statements drawn by systematic reviews and meta-analyses. Herein we discussed the epidemiology of colorectal cancers and adenomas in Korea, optimal screening methods for colorectal cancer, and detection for adenomas including fecal occult blood tests, radiologic tests, and endoscopic examinations. 相似文献
109.
HyunJung Park Soohyun Bae Se Jin Park Ji Yeon Hyun Chang Hyun Lee Dongjin Choi Dongkyun Kang Hyebin Han Yoonmook Kang Hae-Seok Lee Donghwan Kim 《RSC advances》2020,10(30):17571
Correction for ‘Role of polysilicon in poly-Si/SiOx passivating contacts for high-efficiency silicon solar cells’ by HyunJung Park et al., RSC Adv., 2019, 9, 23261–23266. DOI: 10.1039/c9ra03560eThe authors regret that the list of corresponding authors was incorrect in the original article. The corrected author list and associated contact details are as shown above.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. 相似文献
110.
Hwanyeol Park Daekwang Woo Jong Myeong Lee Se Jun Park Sungwoo Lee Ho Jun Kim Euijoon Yoon Gun-Do Lee 《RSC advances》2020,10(12):6822
Amorphous carbon (a-C) films have attracted significant attention due to their reliable structures and superior mechanical, chemical and electronic properties, making them a strong candidate as an etch hard mask material for the fabrication of future integrated semiconductor devices. Density functional theory (DFT) calculations and ab initio molecular dynamics (AIMD) simulations were performed to investigate the energetics, structure, and mechanical properties of the a-C films with an increasing sp3 content by adjusting the atomic density or hydrogen content. A drastic increase in the bulk modulus is observed by increasing the atomic density of the a-C films, which suggests that it would be difficult for the films hardened by high atomic density to relieve the stress of the individual layers within the overall stack in integrated semiconductor devices. However, the addition of hydrogen into the a-C films has little effect on increasing the bulk modulus even though the sp3 content increases. For the F blocking nature, the change in the sp3 content by both atomic density and H concentration makes the diffusion barrier against the F atom even higher and suppresses the F diffusion, indicating that the F atom would follow the diffusion path passing through the sp2 carbon and not the sp3 carbon due to the significantly high barrier. For the material design of a-C films with adequate doped characteristics, our results can provide a new straightforward strategy to tailor the a-C films with excellent mechanical and other novel physical and chemical properties.Amorphous carbon films have attracted significant attention due to their superior mechanical and electronic properties, making them a strong candidate as an etch hard mask material for the fabrication of future integrated semiconductor devices. 相似文献