,,Neuromonitoring`` – was bringt die Zukunft?

Ohne Zusammenfassung     

Anxiety in depression

Even though anxiety in depression is a common clinical condition, there is controversy about its status. Can these patients be dichotomized as having either anxiety or depression, or are there three categories--certain anxiety states, anxiety in depression, and the specific depressive disorders? A review of the findings from four major lines of research on anxiety in depression reveals contradictory results. Anxious depression may be a distinctive entity. The guidelines for diagnosis presented here emphasize the necessity to identify anxious depressed patients and to differentiate them from those with distinctive anxiety states or depressive disorders. Tricyclic medications, such as doxepin, combined with supportive psychotherapy are the treatment of choice for patients with anxiety in depression.     

Kreislaufmechanik bei essentieller und renovaskulärer Hypertonie

Ohne ZusammenfassungMit 8 TabellenMit Unterstützung der Deutschen Forschungsgemeinschaft.     

Epidermal growth factor receptor (EGFR): therapeutic target in the treatment of lung adenocarcinoma

Revolution in biotechnology made possible to identify those gene errors, which via their encoded proteins (mostly kinase enzymes) are key players in tumor development, growth and progression, and could be considered as molecular targets in tumor diagnosis and therapy. Activity of EGFR (epidermal growth factor receptor), an outstanding representative of the regulatory cell surface receptors, can be inhibited by drugs proved for clinical use. In the past year many groups observed that those lung adenocarcinoma cells, which contain activating mutation in the tyrosine kinase domain of EGFR show remarkable sensitivity to anti-EGFR compounds. The basis of the effective therapy is the identification of the mutations. The clinical advantage of EGFR is an example from the coming age of tumor chemotherapy, when the presence of molecular targets will guide the therapeutic choice.