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51.
52.
Gastric angiodysplasia 总被引:1,自引:0,他引:1
53.
WE Gillies FRACO FRACS FRCS Anne MV Brooks MD PhD FRACO FRACS FRACP 《Clinical & experimental ophthalmology》1992,20(3):239-242
A method of combined cataract extraction with posterior chamber intraocular lens and trabeculectomy using separate incisions was tested in 44 operations on 38 patients. The mean preoperative intraocular pressure (IOP) of 28.1 ± 11.7 (range 12 to 56) mmHg on maximum medication was lowered to 13.9 ± 3.4 (9 to 23) mmHg at one year, with half the eyes still requiring topical medication. The IOP was 40 mmHg or more preoperatively in eight eyes and 20 mmHg or more in only two patients at one year. There were no rises in IOP above 20 mmHg in the early postoperative period (days 1 and 2). Visual acuity was 6/9 or better in 27 and 6/12 in three eyes. There was an expulsive haemorrhage in one case, rupture of the posterior capsule in two eyes and a choroidal detachment in one eye, but no flat anterior chambers. The two-incision method allowed placement of an intraocular lens with good postoperative pressure control. 相似文献
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Nash RA; Pineiro LA; Storb R; Deeg HJ; Fitzsimmons WE; Furlong T; Hansen JA; Gooley T; Maher RM; Martin P; McSweeney PA; Sullivan KM; Anasetti C; Fay JW 《Blood》1996,88(9):3634-3641
The safety and potential efficacy of FK506 in combination with a short course of methotrexate (MTX) for the prevention of acute graft-versus- host disease (GVHD) after marrow transplantation from HLA-matched unrelated donors was evaluated in a single-arm Phase II study conducted at two centers. Forty-three patients, 15 to 54 (median 41) years of age, were transplanted for hematologic malignancies. Thirty-seven of 43 evaluable patients had evidence of sustained marrow engraftment. Five patients died before day 17 after transplantation. The median time to an absolute neutrophil count of > 0.5 x 10(5)/L was 21 (range, 14 to 30) days. Nephrotoxicity (serum creatinine concentration > 2 mg/dL or doubling of baseline) occurred in 32 patients (74% cumulative incidence during the first 100 days after transplant). Other adverse effects included hypertension (n = 27), hyperglycemia (n = 27), neurotoxicity (n = 9) and thrombotic thrombocytopenic purpura (n = 2). Severe veno- occlusive disease of the liver occurred in 9 (21%) of the 43 patients. Eighteen patients (42%) developed grades II to IV acute GVHD and five (12%) developed grades III to IV acute GVHD. Twelve of 25 evaluable patients developed extensive chronic GVHD within 1 year of marrow transplantation resulting in an estimate of the probability of developing this complication of 48%. The cumulative incidence of transplant-related mortality during the first 100 days was 37%. Kaplan- Meier estimates of disease-free survival at 2 years for good-risk, poor- risk, and all patients were 65%, 4%, and 32%, respectively. FK506 in combination with a short course of MTX appears active in preventing acute GVHD after marrow transplantation from unrelated donors. Further studies comparing the combination of FK506 and MTX with cyclosporine and MTX for the prevention of acute GVHD are warranted. 相似文献
56.
Percutaneous transluminal angioplasty: the treatment of choice for renovascular hypertension due to fibromuscular dysplasia 总被引:2,自引:0,他引:2
Tegtmeyer CJ; Elson J; Glass TA; Ayers CR; Chevalier RL; Wellons HA Jr; Studdard WE Jr 《Radiology》1982,143(3):631-637
Twenty-three renal artery stenoses in 21 hypertensive patients, caused by fibromuscular dysplasia, were treated with percutaneous transluminal angioplasty (PTA). Follow-up over a period of 1 to 30 months, including angiography, renal vein renin assay, and radionuclide flow studies, was performed in 8 patients, each with one stenosis. Dilatation was initially successful in all cases and was successfully repeated in 1 case. The mean systolic pressure decreased by 61.81 mm Hg and the mean diastolic pressure by 36.28 mm Hg in response to treatment. Thirteen patients were cured, 8 were felt to have better control of blood pressure on medication, and there was no failures. This study demonstrates that PTA is a clinically effective method of treating renovascular hypertension due to fibromuscular dysplasia. 相似文献
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目的利用磁共振成像(MRI)对儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的上气道结构进行测量分析,探讨儿童OSAHS上气道的结构特点。方法选择原发性鼾症组(Ps组)30例和OSAHS组30例,同时随机选择30例正常儿童作为对照组,应用MRI对上气道进行空间测量和软组织测量,结果进行统计学分析。结果①空间测量:3组儿童之间相比,鼻咽气道截面积、口咽气道截面积、腭咽气道截面积、气道斜径,比较差异有统计学意义(P〈0.05);②软组织测量:舌体截面积3组之间差异无统计学意义(P〉0.05);OSAHS组比Ps组及对照组腺样体截面积大、腺样体斜距长,比较有统计学意义(P〈0.05);OSAHS组、Ps组比对照组扁桃体截面积大,比较有统计学意义(P〈0.05)。结论应用MRI可以判定OSAHS儿童上气道的狭窄情况,可作为诊断儿童OSAHS的重要辅助手段。 相似文献
59.
目的比较硼替佐米+地塞米松+沙利度胺(BDT)方案与长春地辛+表柔比星+地塞米松+沙利度胺(VADT)方案治疗多发性骨髓瘤(MM)的临床效果。方法MM病人67例,应用BDT方案治疗30例,VADT方案治疗37例,均治疗4个疗程,比较两组治疗前、治疗后β2-微球蛋白、免疫球蛋白、骨髓瘤细胞的变化,并比较两组疗效。结果BDT组及VADT组化疗后β2-微球蛋白、免疫球蛋白、骨髓瘤细胞均低于化疗前,差异有显著性(t=2.837~7.562,P%0.05)。BDT组完全缓解(CR)占13.0%,接近完全缓解(ncR)占20.0%,部分缓解(PR)占53.0%,微小反应(MR)占6.7%,总有效率93.3%;VADT组CR占3.0%,nCR占10.8%,PR占40.5%,MR占16.2%,总有效率70.3%,两组疗效比较,差异有显著性(Hc=51.67,P〈0.05)。结论BDT方案治疗MM效果优于VADT方案,且起效快,可改善病人的预后。 相似文献
60.
Atherosclerosis is a chronic inflammatory disorder of the vasculature and is the primary cause of cardiovascular disease(CVD). CVD is currently the world's leading cause of death and the numbers are predicted to rise further because of a global increase in risk factors such as diabetes and obesity. Current therapies such as statins have had a major impact in reducing mortality from CVD. However, there is a marked residual CVD risk in patients on statin therapy. It is therefore important to understand the molecular basis of this disease in detail and to develop alternative novel therapeutics. Interferon-γ(IFN-γ) is a pro-inflammatory cytokine that is often regarded as a master regulator of atherosclerosis development. IFN-γ is able to influence several key steps during atherosclerosis development, including pro-inflammatory gene expression, the recruitment of monocytes from the blood to the activated arterial endothelium and plaque stability. This central role of IFN-γ makes it a promising therapeutic target. The purpose of this editorial is to describe the key role IFN-γ plays during atherosclerosis development, as well as discuss potential strategies to target it therapeutically. 相似文献