全文获取类型
收费全文 | 893篇 |
免费 | 60篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 63篇 |
妇产科学 | 10篇 |
基础医学 | 144篇 |
口腔科学 | 2篇 |
临床医学 | 57篇 |
内科学 | 182篇 |
皮肤病学 | 2篇 |
神经病学 | 76篇 |
特种医学 | 51篇 |
外科学 | 125篇 |
预防医学 | 28篇 |
眼科学 | 127篇 |
药学 | 19篇 |
中国医学 | 3篇 |
肿瘤学 | 69篇 |
出版年
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 13篇 |
2018年 | 20篇 |
2017年 | 15篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 25篇 |
2013年 | 38篇 |
2012年 | 41篇 |
2011年 | 54篇 |
2010年 | 19篇 |
2009年 | 19篇 |
2008年 | 44篇 |
2007年 | 42篇 |
2006年 | 49篇 |
2005年 | 56篇 |
2004年 | 47篇 |
2003年 | 47篇 |
2002年 | 43篇 |
2001年 | 25篇 |
2000年 | 17篇 |
1999年 | 14篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 5篇 |
1993年 | 10篇 |
1992年 | 21篇 |
1991年 | 21篇 |
1990年 | 18篇 |
1989年 | 24篇 |
1988年 | 18篇 |
1987年 | 16篇 |
1986年 | 15篇 |
1985年 | 21篇 |
1984年 | 14篇 |
1983年 | 18篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1968年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有962条查询结果,搜索用时 15 毫秒
91.
Mantovani A Garlanda C Locati M Rodriguez TV Feo SG Savino B Vecchi A 《Autoimmunity reviews》2007,7(1):8-11
Tuning is a key aspect of inflammatory reaction essential in homeostasis and pathology. An emerging mechanism for negative regulation of proinflammatory cytokines is based on non-signaling IL-1/TLR receptors and chemokine receptors competing with signaling receptors for ligand binding and sustaining ligand internalization and degradation. Biological activities of IL-1R/TLR receptors are under control of membrane-bound binding molecules lacking the signaling domain, soluble receptor antagonists, and intracellular signaling inhibitors. The chemokine system includes at least three 'silent' receptors with distinct specificity and tissue distribution. D6 is the best characterized representative member of this class of negative regulators, binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene targeted mice, is consistent with the view that these non-signaling receptors for proinflammatory cytokines possess unique functional and structural features which make them ideally adapted to act as a decoy and scavenger receptors, with a non redundant role in dampening tissue inflammation and tuning draining lymph nodes reactivity. 相似文献
92.
Milena Ferro Gabriella Macchia Alessia Re Milly Buwenge Marica Ferro Mariangela Boccardi Vincenzo Picardi Anna Ianiro Eleonora Arena Alice Zamagni Eleonora Farina Savino Cilla Vincenzo Valentini Alessio Giuseppe Morganti Francesco Deodato 《Journal of Geriatric Oncology》2021,12(3):441-445
ObjectivesTo assess the feasibility and safety of a repeated SHort course Accelerated RadiatiON therapy (SHARON) regimen in the palliative setting of Head and Neck (H&N) cancer in older adults.Material and MethodsPatients with histological confirmed H&N cancers, age ≥ 80 years, expected survival >3 months, and Eastern Cooperative Oncology Group (ECOG) performance status of ≤3 were enrolled. Patients were treated in cohorts of six patients: a total dose of 20 Gy was delivered in 2 consecutive days with a twice-daily fractionation (5 Gy per fraction) and at least 8-h interval. If no Grade 3 toxicity was registered, a second enrollment started with another cohort of six patients to whom were administered two cycles (total dose of 40 Gy). The primary endpoint was to evaluate the feasibility of the two cycles of treatment. Secondary endpoints were evaluation of symptoms control rate, symptoms-free survival (SFS), and Quality of Life (QoL) scores.ResultsSeventeen consecutive patients (median age: 85 years) were treated. Nine patients were treated with one cycle and 8 patients with two cycles. No G3 toxicity was reported in either cohort. With a median follow-up time of 4 months, 3-month SFS in the first and second cohorts was 83.3%, and 87.5%, respectively. The overall palliative response rate was 88%. Among 13 patients reporting pain, 8 (61.5%) showed an improvement or resolution of their pain.ConclusionRepeated short course accelerated radiotherapy in a palliative setting of H&N cancers is safe and well-tolerated in older adults. 相似文献
93.
94.
Ketty Savino Elisa Quintavalle Giuseppe Ambrosio 《Journal of Cardiovascular Echography》2015,25(3):72-76
The quadricuspid aortic valve (QAV) is a rare malformation; often isolated, sometimes associated with other heart diseases. Before the era of echocardiography, the diagnosis was made incidentally at autopsy or during surgery of valve replacement. The extensive use of echocardiography has allowed an early and accurate diagnosis of this malformation. In many cases, the transthoracic approach is suitable for the diagnosis but, transesophageal echocardiography is a tool for the accurate definition of the valve anatomy. This review analyzes, after the presentation of a clinical case, the current knowledge on embryogenesis, classification, diagnosis and clinical course of QAV. 相似文献
95.
Natali R Lotrionte M Marchese N Di Giannuario G Brugaletta S Pisanello C Comerci G Savino M Lombardo A Forni F Vigna C Loperfido F 《Minerva cardioangiologica》2008,56(3):277-285
AIM: The aim of this study was to determine if low-dose dobutamine stress echocardiography (LD-DSE) is associated with functional capacity in unselected elderly patients with chronic heart failure. METHODS: This was a prospective trial.Thirty five consecutive patients were included, with age >65 years and left ventricular dysfunction (12 ischemic), by blindly assessed LD-DSE and cardiopulmonary exercise testing (CPT). Contractile reserve was defined as a change (D) in wall motion score index (WMSI) = or <0.2 at peak dose dobutamine. At CPT treadmill exercise time, peak VO2, %Vo2 and VE/VCO2 slope were determined. Preserved functional capacity was defined as percent of maximal predicted O2 consumption (%VO2) >80%. Baseline NT-proBNP plasma levels were assessed. RESULTS: CPT variables were not related to clinical and baseline echocardiography characteristics but were related to DWMSI (exercise time, P=0.004; peak VO2, P=0.008; %VO2, P<0.001; VE/Vco2, P<0.001). Contractile reserve was present in 16 of 17 patients with preserved functional capacity (sensitivity=94%) and in 2 of 13 patients without (specificity=85%). Baseline NT-proBNP levels were lower in patients with contractile reserve (476+/-365 pg/mL) than in those without (1 345+/-1 219 pg/mL) (P=0.019), but were mildly related to CPT variables (P=0.049 and 0.027 with exercise time and %VO2, respectively). CONCLUSION: Contractile reserve elicited at LD-DSE is associated with functional capacity in unselected elderly patients with chronic heart failure. 相似文献
96.
BACKGROUND: Biagram vector is derived by plotting direct measurements of reactance and phase angle from the analyzer, which are not dependent on anthropometric characteristics of the subject and it can be considered an emerging method for evaluating the nutritional status in clinical practice. AIM: To calculate and plot the Biagram vector in a sample of healthy infants in their first year of life. METHODS: 174 healthy infants (99 male, 75 female) aged under 1 year, born at full term and adequate for gestational age, were enrolled in a cross-sectional study. The sample was divided into three age groups: 0-3.99 months (group A), 4-7.99 months (group B), and 8-11.99 months (group C). Bioelectric impedance analysis (BIA) was performed by a tetrapolar single frequence phase-sensitive impedance analyzer (STA/BIA; Akern Srl, Firenze, Italy). RESULTS: Biagram vector showed an increasing trend (p < 0.05) in the first year of life (group A: 27.9 +/- 12.6; group B: 32.1 +/- 9.7; group C: 37.2 +/- 9.5). Females showed Biagram vector values significantly higher than males in group A (34.7 +/- 15.0 vs. 24.0 +/- 9.1; p < 0.05). 95% confidence ellipses of Biagram vector for each age group were calculated and plotted and a comparison of our results with published data calculated in older children was conducted. CONCLUSION: The bivariate analysis of BIA measurements, plotted as a vector in relation to the age, showed an increasing trend with a higher gain rate under 1 year with respect to the following age periods. These data could reflect the variation of body composition in the first years of life and could be of interest to assess the nutritional status for clinical practice. 相似文献
97.
G Corrado A Sgalambro A Mantero F Gentile M Gasparini R Bufalino A Morabito G Trocino R Schiavina S Mandorla R Mangia D Tovena K Savino F Jacopi E M Pellegrino F Agostini G Centonze F Bovenzi E Caprino G Tadeo M Santarone 《European heart journal》2001,22(12):1042-1051
AIMS: Patients with atrial flutter are believed to be at lower risk of thromboembolism than patients with atrial fibrillation. However, the incidence of atrial thrombi and the need for anticoagulation in patients with atrial flutter is not well established. METHODS AND RESULTS: A prospective observational multicentre study was undertaken to assess the frequency of atrial thrombi and spontaneous echocontrast and the prevalence for aortic complex atherosclerotic lesions in a cohort of unselected patients with atrial flutter. We evaluated 134 patients (102 male, aged 70+/-9 years); exclusion criteria were history of atrial fibrillation, rheumatic mitral valve disease and mitral mechanical prosthesis. The median of atrial flutter duration was 33 days. Twelve patients had been taking warfarin for more than 7 days. One hundred and twenty-four patients (94%) underwent a transoesophageal echocardiogram, which revealed left atrial appendage thrombi in two patients (1.6%) and right atrial thrombi in one patient (1%). At least moderate left atrial echocontrast was found in 16/124 patients (13%). Complex atherosclerotic aortic plaques were detected in 10 patients (8%). Atrial flutter conversion was attempted in 93/134 patients (69%). At the 1-month follow-up, two patients experienced a thromboembolic event following restoration of sinus rhythm. CONCLUSIONS: Atrial thrombi and echocontrast, and complex aortic atherosclerotic plaques are relatively uncommon in patients with atrial flutter. Post-cardioversion embolism was observed in two patients in our study population. 相似文献
98.
Santambrogio R Costa M Barabino M Zuin M Bertolini E De Filippi F Bruno S Opocher E 《Surgical endoscopy》2012,26(4):1108-1115
Background
Aggressive treatment of intrahepatic recurrence of hepatocellular carcinoma (HCC) increases patients’ survival. This study aimed to evaluate laparoscopic thermal ablation (TA) in the treatment of intrahepatic HCC recurrences. 相似文献99.
Bernard Schachtel Sue Aspley Adrian Shephard Timothy Shea Gary Smith Kathleen Sanner Laurie Savino Jeanne Rezuke Emily Schachtel 《Pain》2014
A new onset-of-action model was utilized to distinguish the pharmacologic activity of flurbiprofen 8.75 mg delivered in a lozenge from the demulcent effect of the lozenge base. In a randomized, double-blind, placebo-controlled trial, patients with sore throat rated pain on a Sore Throat Pain Intensity Scale before taking one flurbiprofen or placebo lozenge and at frequent (2-minute) intervals over the first hour after treatment. Further ratings of the Sore Throat Pain Intensity Scale and other patient-reported outcomes (difficulty swallowing, swollen throat, pain relief) were obtained at varying intervals over 6 hours. Onset of pharmacologic activity was defined as the median time of first perceived pain reduction if a patient reported clinically meaningful (at least moderate) relief. The conventional method of comparing mean treatment responses at each time point was also implemented. Demulcent action was detected at the first 2-minute assessment. By the new method, 102 flurbiprofen-treated patients were identified as first perceiving pain relief at 12 minutes, compared with >120 minutes by 102 patients using placebo (P < 0.001). By the conventional method, mean percentage pain reduction for flurbiprofen 8.75 mg was first significantly differentiated from placebo at 26 minutes (P < 0.05). Efficacy of flurbiprofen lozenge was demonstrated for 3.5-4 hours on the 4 patient-reported outcomes (all P < 0.05 compared with placebo). There were no serious adverse events. This patient-centered onset-of-action model identifies the initiation of pain relief in patients who are definite drug responders, here demonstrating that a flurbiprofen 8.75-mg lozenge provides early relief of sore throat. 相似文献
100.
Giuseppe Giordano Luigi Fanzone Diego Meo Sebastiano Piana Viviana Lentini Savino Borracino Enrico Potenza Vincenzo Magnano San Lio 《Radiology Case Reports》2021,16(9):2437
We report the case of a woman with a mass in the anterior and middle mediastinum (a non-small-cell lung carcinoma), determining significant compression of both superior vena cava and right pulmonary artery. The patient developed acute respiratory distress syndrome , necessitating intubation and admission to the Intensive Care Unit . Radiotherapy sessions to reduce the mass effect were attempted, without significant clinical improvement. Due to the persistence of severe hypoxemia, stenting of the superior vena cava and the right pulmonary artery was performed, the latter resulting in a significant improvement of the arterial blood gas parameters, allowing extubation of the patient. In our opinion, stenting of the superior vena cava and the pulmonary artery (or its branches) is an effective and safe treatment; it should be considered in similar cases, especially if other - less invasive - treatments fail. 相似文献