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951.
A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids. 相似文献
952.
The in vivo dietary fiber contents of wheat milling fractions and wheat foods, determined in rat feeding experiments, were compared with dietary fiber values determined in vitro with pronase alpha-amylase digestion. Both types of dietary fiber values were compared with crude fiber and neutral detergent fiber values in the same materials. Regression analyses indicated close correlation amongst all values determined. It appears that laboratory analysis for crude fiber, neutral detergent fiber, or in vitro dietary fiber accurately predicts in vivo dietary fiber (rats) for wheat milling fractions when the laboratory result is adjusted by means of an appropriate regression equation. 相似文献
953.
954.
S. N. Hunyor D. M. Saunders G. R. Bellamy D. Roffe E. Harford A. Helfgott 《Clinical and experimental pharmacology & physiology》1982,9(3):315-320
1. Venous compliance and plasma volume were measured in thirty-one continuously normotensive women early (11-20 weeks) and late (31-40 weeks) in pregnancy and following delivery. 2. Mathematically fitted pressure/volume curves, obtained by venous occlusion plethysmography, were analysed according to two describing functions (i) the peak of the first derivative dv/dp max and (ii) a work index, ∫2510p dv. 3. The relationship between venous/volume factors seen after delivery, was disturbed during pregnancy, at which time the work index provided evidence for decreased venous compliance. 4. Pregnancy could be regarded as a potentially hypertensive state, brought about by a vascular/volume mismatch. 相似文献
955.
956.
Synthesis and transport of lipoprotein particles by intestinal absorptive cells in man 总被引:2,自引:2,他引:0 下载免费PDF全文
Guido N. Tytgat Cyrus E. Rubin David R. Saunders 《The Journal of clinical investigation》1971,50(10):2065-2078
The site of synthesis and some new details of lipoprotein particle transport have been demonstrated within the jejunal mucosa of man. In normal fasting volunteers, lipoprotein particles (88%, 150-650 A diameter) were visualized within the smooth endoplasmic reticulum and Golgi cisternae of absorptive cells covering the tips of jejunal villi. Electron microscopic observations suggested that these particles exited through the sides and bases of absorptive cells by reverse pinocytosis and then passed through the extracellular matrix of the lamina propria to enter lacteal lumina. 相似文献
957.
958.
959.
J Cleary R A Saunders 《Clinica chimica acta; international journal of clinical chemistry》1974,57(3):217-223
A simple method for the estimation of hydroxyproline is described. Removal of acid, salts and pigments from hydrolysed urine is achieved by passing the urine hydrolysate through a column of ion retardation resin. Oxidation and chromophore development follow directly on an aliquot of the column elutate. All the parameters of the reaction have been studied and conditions described which give the most sensitive and stable colour development. Recoveries of 97% or better are obtained with precision of replicates of ± 3%. The method is inexpensive, rapid and not subject to interference from other compounds commonly present in urine. 相似文献
960.
Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig 总被引:1,自引:0,他引:1
The ability of synthetic platelet-activating factor (PAF) given intravenously to produce loss (extravasation) of protein rich plasma (resulting in hemoconcentration) has been examined using guinea pigs. Hemoconcentration induced by PAF was not prevented by prior administration of inhibitors of thromboxane synthetase (7-(3-pyridyl)heptanoic acid, UK-37,248-01), PGI2, aspirin, indomethacin or antiserum induced thrombocytopenia. Calcium channel blockers (nifedipine, verapamil, diethylamino octyltrimethoxybenzoate, diltiazem), antihistamines (pyrilamine, cimetidine, diphenhydramine), or the elevator of cAMP IBMX were ineffective in blocking PAF-induced hemoconcentration. In contrast, CV-3988, reported to be a specific antagonist to PAF, was 98% inhibitory of PAF extravasation when given i.a. at 3.5 mg/kg. The ED50 was 0.14 mg/kg I.A. and 15 mg/kg p.o. against 75 ng/kg PAF. These data suggest that PAF-induced hemoconcentration involves receptor mediated alterations of vascular permeability that are inhibited by a specific PAF antagonist. 相似文献