全文获取类型
收费全文 | 62821篇 |
免费 | 4970篇 |
国内免费 | 127篇 |
专业分类
耳鼻咽喉 | 407篇 |
儿科学 | 2707篇 |
妇产科学 | 2017篇 |
基础医学 | 8023篇 |
口腔科学 | 708篇 |
临床医学 | 8699篇 |
内科学 | 11617篇 |
皮肤病学 | 1118篇 |
神经病学 | 6804篇 |
特种医学 | 1099篇 |
外科学 | 5697篇 |
综合类 | 690篇 |
现状与发展 | 1篇 |
一般理论 | 102篇 |
预防医学 | 8875篇 |
眼科学 | 948篇 |
药学 | 4031篇 |
中国医学 | 69篇 |
肿瘤学 | 4306篇 |
出版年
2024年 | 101篇 |
2023年 | 790篇 |
2022年 | 1208篇 |
2021年 | 2327篇 |
2020年 | 1471篇 |
2019年 | 2198篇 |
2018年 | 2484篇 |
2017年 | 1760篇 |
2016年 | 1967篇 |
2015年 | 2079篇 |
2014年 | 2759篇 |
2013年 | 3755篇 |
2012年 | 5465篇 |
2011年 | 5317篇 |
2010年 | 2783篇 |
2009年 | 2482篇 |
2008年 | 3900篇 |
2007年 | 4134篇 |
2006年 | 3673篇 |
2005年 | 3543篇 |
2004年 | 3197篇 |
2003年 | 2762篇 |
2002年 | 2588篇 |
2001年 | 367篇 |
2000年 | 280篇 |
1999年 | 374篇 |
1998年 | 523篇 |
1997年 | 350篇 |
1996年 | 303篇 |
1995年 | 314篇 |
1994年 | 278篇 |
1993年 | 243篇 |
1992年 | 164篇 |
1991年 | 141篇 |
1990年 | 150篇 |
1989年 | 123篇 |
1988年 | 98篇 |
1987年 | 95篇 |
1986年 | 100篇 |
1985年 | 120篇 |
1984年 | 129篇 |
1983年 | 94篇 |
1982年 | 117篇 |
1981年 | 103篇 |
1980年 | 99篇 |
1979年 | 66篇 |
1978年 | 69篇 |
1977年 | 51篇 |
1975年 | 42篇 |
1972年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 14 毫秒
81.
82.
David G Hicks Brian J Yoder Sarah Short Shannon Tarr Nichole Prescott Joseph P Crowe Andrea E Dawson G Thomas Budd Steven Sizemore Muzaffer Cicek Toni K Choueiri Raymond R Tubbs Daniel Gaile Norma Nowak Mary Ann Accavitti-Loper Andra R Frost Danny R Welch Graham Casey 《Clinical cancer research》2006,12(22):6702-6708
PURPOSE: This study aims to determine the effect of loss of breast cancer metastasis suppressor 1 (BRMS1) protein expression on disease-free survival in breast cancer patients stratified by estrogen receptor (ER), progesterone receptor (PR), or HER2 status, and to determine whether loss of BRMS1 protein expression correlated with genomic copy number changes. EXPERIMENTAL DESIGN: A tissue microarray immunohistochemical analysis was done on tumors of 238 newly diagnosed breast cancer patients who underwent surgery at the Cleveland Clinic between January 1, 1995 and December 31, 1996, and a comparison was made with 5-year clinical follow-up data. Genomic copy number changes were determined by array-based comparative genomic hybridization in 47 breast cancer cases from this population and compared with BRMS1 staining. RESULTS: BRMS1 protein expression was lost in nearly 25% of cases. Patients with tumors that were PR negative (P=0.006) or HER2 positive (P=0.039) and <50 years old at diagnosis (P=0.02) were more likely to be BRMS1 negative. No overall correlation between BRMS1 staining and disease-free survival was observed. A significant correlation, however, was seen between loss of BRMS1 protein expression and reduced disease-free survival when stratified by either loss of ER (P=0.008) or PR (P=0.029) or HER2 overexpression (P=0.026). Overall, there was poor correlation between BRMS1 protein staining and copy number status. CONCLUSIONS: These data suggest a mechanistic relationship between BRMS1 expression, hormone receptor status, and HER2 growth factor. BRMS1 staining could potentially be used in patient stratification in conjunction with other prognostic markers. Further, mechanisms other than genomic deletion account for loss of BRMS1 gene expression in breast tumors. 相似文献
83.
Triplet morbidity and mortality in a large case series. 总被引:1,自引:0,他引:1
OBJECTIVE: A significant increase in the triplet birth rate has occurred recently. This rise is of concern, as these infants are historically reported to be at risk of adverse outcome. Thus, we examined the outcome of triplet births in a large contemporary case series. STUDY DESIGN: Since 1993, detailed clinical data have been collected on all patients admitted to our Neonatal Intensive Care Unit. We retrospectively analyzed this database to examine triplet outcome. RESULTS: A total of 51 consecutive sets of triplets were born over a 9-year period. The mean birth weight for triplets was 1789+/-505 g, mean gestational age was 32.6+/-2.7 weeks, with discordancy present in 17.6% of neonates. Complications of prematurity were infrequent. Triplet survival to discharge was 96%. CONCLUSIONS: This large contemporary case series of triplets demonstrates excellent survival with low associated morbidity. These data suggest that there may no longer be medical justification for offering selective fetal reduction to parents with triplet pregnancies. 相似文献
84.
Michael J. Bernas Robert L. Askew Jane M. Armer Janice N. Cormier 《Current breast cancer reports》2010,2(1):53-58
Lymphedema is an under-recognized, progressive, life-long condition estimated to impact 2-3 million people in the United States.
The incidence of breast cancer related lymphedema varies greatly in the literature largely due to different measurement techniques,
competing thresholds for defining lymphedema, and variation in length of follow-up. Multiple imaging techniques have become
useful for diagnosis. Lymphoscintigraphy is one of the most commonly used, as it can identify pathways of lymphatic drainage,
quantify extent of dermal backflow, and help determine functional and morphologic changes in the lymphatic system. Early detection
and intervention hold the greatest promise of reducing the incidence of lymphedema. Health care providers involved with cancer
patients need to become more educated about lymphedema, aware of current risk-reduction practices, and familiar with methods
of diagnosis and assessment, so that patients with early swelling can be referred to lymphedema treatment specialists at a
time when treatment is more effective. 相似文献
85.
86.
87.
Scarlett Lin Gomez Cynthia D O'Malley Antoinette Stroup Sarah J Shema William A Satariano 《BMC cancer》2007,7(1):193
Background
Colorectal cancer, if detected early, has greater than 90% 5-year survival. However, survival has been shown to vary across racial/ethnic groups in the United States, despite the availability of early detection methods. 相似文献88.
89.
Mark Chaffin Jane F Silovsky Christy Vaughn 《Journal of clinical child and adolescent psychology》2005,34(2):210-222
This study examined the temporal concordance between the onset of childhood anxiety disorders and the points of onset and ending of child sexual abuse (CSA). Sexually abused children (N = 158) were assessed with structured diagnostic interviews. Onset ages for lifetime prevalence anxiety disorders were combined and sequenced with the onset and ending of sexual abuse. Hazard rates were calculated. Departures from the overall linear hazard trajectory for onsets were modeled using piecewise growth curve analyses. Increases from the overall trajectory were found around the point of sexual abuse onset for most childhood anxiety disorders. Decreases were found around the ending of sexual abuse. The risk for developing new anxiety disorders after the onset of sexual abuse showed a positive dose-effect relation with abuse severity. The findings add support to the idea that CSA can have a direct link to childhood anxiety disorders, apart from confounded vulnerability factors, postabuse events, or stable family background factors. The findings are contrasted with those from cross-sectional partial correlation studies that have suggested that there is little direct connection between sexual abuse and mental health outcomes. 相似文献
90.
Roberto Civitelli M.D. Eturo Ogata Louis V. Avioli Gary Stein Samuel Edelstein John A. Eisman Yasuho Nishii Hajime Orimo Jane Lian Takuo Fujita Yasufumi Hayashi Shigeaki Kato Tadashi Kobayashi Hirotoshi Morii Rikushi Morita Toshitaka Nakamura Yoshiki Seino Masataka Shiraki Tatsuo Suda Naoyuki Takahashi Hideaki Takahashi Tastuhiko Tanisawa Akifumi Tokita 《Calcified tissue international》1995,57(6):409-414