全文获取类型
收费全文 | 607篇 |
免费 | 39篇 |
国内免费 | 13篇 |
专业分类
儿科学 | 29篇 |
妇产科学 | 34篇 |
基础医学 | 34篇 |
口腔科学 | 14篇 |
临床医学 | 74篇 |
内科学 | 112篇 |
皮肤病学 | 4篇 |
神经病学 | 22篇 |
特种医学 | 187篇 |
外科学 | 53篇 |
综合类 | 40篇 |
预防医学 | 8篇 |
眼科学 | 4篇 |
药学 | 13篇 |
1篇 | |
肿瘤学 | 30篇 |
出版年
2022年 | 3篇 |
2021年 | 11篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 11篇 |
2014年 | 13篇 |
2013年 | 9篇 |
2012年 | 25篇 |
2011年 | 20篇 |
2010年 | 12篇 |
2009年 | 14篇 |
2008年 | 6篇 |
2007年 | 14篇 |
2006年 | 18篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 15篇 |
2002年 | 4篇 |
2001年 | 13篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 25篇 |
1997年 | 23篇 |
1996年 | 17篇 |
1995年 | 25篇 |
1994年 | 20篇 |
1993年 | 33篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 13篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 38篇 |
1986年 | 21篇 |
1985年 | 25篇 |
1984年 | 9篇 |
1983年 | 15篇 |
1982年 | 9篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1971年 | 3篇 |
1970年 | 6篇 |
1968年 | 3篇 |
1967年 | 4篇 |
排序方式: 共有659条查询结果,搜索用时 15 毫秒
651.
652.
Pietro Santulli Laurent Mandelbrot Enrico Facchiano Chloé Dussaux Pierre-François Ceccaldi Séverine Ledoux Simon Msika 《Obesity surgery》2010,20(11):1501-1508
Background
The objective of this study was to analyze obstetrical and neonatal outcomes following Roux en Y Gastric Bypass procedures (RYGBP). 相似文献653.
C Evans N Peter M Gibson EPH Torrie RB Galland TR Magee 《Annals of the Royal College of Surgeons of England》2010,92(4):347-352
INTRODUCTION
Retrograde transpopliteal angioplasty (PA) is a potentially useful alternative technique for endovascular treatment of infra-inguinal arterial disease when antegrade transfemoral puncture (FA) is technically not possible or appropriate. This study aimed to investigate the outcomes of PA compared with FA during a 5-year period.PATIENTS AND METHODS
A retrospective study was performed to assess 88 PA and 275 FA performed between January 2003 and January 2008. Assessments of patients, indication for procedure, disease site, stenosis severity, procedure outcomes and time to further intervention were recorded.RESULTS
FA was used to treat more patients with critical ischaemia (42.2% vs 30.7%; P = 0.014)). PA was used to treat more proximal superficial femoral lesions (P < 0.001) and occlusive lesions (P = 0.001). Overall, 84.1% of PA and 82.5 % of FA were technically successful. There was no difference in local puncture site complication rates. Significantly more FA resulted in distal thrombus/embolism (8.4% vs 3.4%; P = 0.044). Further intervention was required in 27.3% of PA and 36.0% of FA. The time interval to re-intervention was not different between the groups.CONCLUSIONS
PA is safe with comparable success rates and long-term outcomes to an FA. PA is a useful alternative approach or treating occlusive, proximal disease. 相似文献654.
Lt Col Sourav Sen Sunil Sanghi ) Col K Shanmuganandan )RM Gupta ) Brig Ketoki Kapila AK Praharaj Col Satish Kumar RB Batra 《Medical Journal Armed Forces India》2011,67(1):15-20
Background: Studies in human immunodeficiency virus (HIV) infected adults have demonstrated association of total lymphocyte count (TLC) <1200/mm3 and subseqnent disease progression or mortality. The association of other surrogate makers such as haemoglobin (Hb), and erythrocyte sedimentation rate (ESR) with CD4 count and disease progression has also been suggested. This study was carried out to determine the relationship of CD4-positive T lymphocyte counts with TLC, Hb and ESR in HIV-infected individuals.Methods: The study population comprised of 215 antiretroviral treatment naive HIV-1 infected adults. The CD4 positive T cell counts, TLC, Hb and ESR of study participants were measured. Spearman's rank order correlation and Receiver Operating Characteristic were used for statistical analyses.Result: The sensitivity, specificity, positive and negative likelihood ratios for cut-off value of TLC <1200/mm3 for predicting CD4 counts <200 cells/mm3 and <350 cells/mm3 were 9.4%, 100%, not measurable and 1.1, and 6.1 %, 98.8 %, 5.13 and 0.95, respectively. The association of Hb (<10, 11, 12 g/dl and <10, 12, 14 g/dl for CD4 counts <200 cells/mm3 and <350 cells/mm3, respectively), and ESR (<10, 20 and 30 mm fall after 1 hour) with these two CD4 counts cut-off values were suboptimal.Conclusion: This study reveals the poor association of TLC, Hb, and ESR with CD4 counts in HIV infected adults, thus highlighting the need to review the utility of these surrogate markers, for predicting CD4 counts in people living with HIV/AIDS. 相似文献
655.
CRM Lammens EMA Bleiker S Verhoef FJ Hes MGEM Ausems D Majoor‐Krakauer RH Sijmons RB Van Der Luijt AMW Van Den Ouweland Tam Van Os N Hoogerbrugge EB Gómez García CJ Dommering CM Gundy NK Aaronson 《Clinical genetics》2010,77(5):483-491
Lammens CRM, Bleiker EMA, Verhoef S, Hes FJ, Ausems MGEM, Majoor‐Krakauer D, Sijmons RH, Luijt van der RB, Ouweland van den AMW, Van Os Tam, Hoogerbrugge N, Gomez‐Garcia EB, Dommering CJ, Gundy CM, Aaronson NK. Psychosocial impact of von Hippel–Lindau disease: levels and sources of distress. Von Hippel–Lindau disease (VHL) is a hereditary tumor susceptibility syndrome, characterized by an increased risk of developing multiple benign and malignant tumors at various sites and ages with limited preventive options. This study evaluates the prevalence of distress among VHL family members and factors associated significantly with such distress. Forty‐eight families with a VHL mutation were identified via the nine family cancer clinics in the Netherlands. In total, 171 family members (carriers, 50% at‐risk, non‐carriers) were approached, of whom 123 (72%) completed a self‐report questionnaire. Approximately 40% of the VHL family members reported clinically relevant levels of distress, approaching 50% among the carriers and, possibly even more striking, 36% among the non‐carriers. Having lost a first degree relative due to VHL during adolescence (OR 11.2; 95% CI 1.4–86.9) was related significantly to heightened levels of distress. Approximately, only one‐third of those who reported heightened levels of distress had received professional psychosocial support. A substantial percentage of family members experience clinically relevant levels of distress. We would recommend the introduction of a procedure for screening for distress in this vulnerable population. Special attention should be paid to those individuals who have lost a close relative due to VHL during adolescence. 相似文献
656.
Santulli RJ Kinney WA Ghosh S Decorte BL Liu L Tuman RW Zhou Z Huebert N Bursell SE Clermont AC Grant MB Shaw LC Mousa SA Galemmo RA Johnson DL Maryanoff BE Damiano BP 《The Journal of pharmacology and experimental therapeutics》2008,324(3):894-901
The alpha(V) integrins are key receptors involved in mediating cell migration and angiogenesis. In age-related macular degeneration (AMD) and diabetic retinopathy, angiogenesis plays a critical role in the loss of vision. These ocular vasculopathies might be treatable with a suitable alpha(V) antagonist, and an oral drug would offer a distinct advantage over current therapies. (3,S,beta,S)-1,2,3,4-Tetrahydro-beta-[[1-[1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl]-4-piperidinyl]methyl]-3-quinolinepropanoic acid (JNJ-26076713) is a potent, orally bioavailable, nonpeptide alpha(V) antagonist derived from the arginine-glycine-asparagine binding motif in the matrix protein ligands (e.g., vitronectin). This compound inhibits alpha(V)beta(3) and alpha(V)beta(5) binding to vitronectin in the low nanomolar range, it has excellent selectivity over integrins alpha(IIb)beta(3) and alpha(5)beta(1), and it prevents adhesion to human, rat, and mouse endothelial cells. JNJ-26076713 blocks cell migration induced by vascular endothelial growth factor, fibroblast growth factor (FGF), and serum, and angiogenesis induced by FGF in the chick chorioallantoic membrane model. JNJ-26076713 is the first alpha(V) antagonist reported to inhibit retinal neovascularization in an oxygen-induced model of retinopathy of prematurity after oral administration. In diabetic rats, orally administered JNJ-26076713 markedly inhibits retinal vascular permeability, a key early event in diabetic macular edema and AMD. Given this profile, JNJ-26076713 represents a potential therapeutic candidate for the treatment of age-related macular degeneration, macular edema, and proliferative diabetic retinopathy. 相似文献
657.
Laura A. Rabin Andrew J. Saykin John D. West Marlana J. Borgos Heather A. Wishart Katherine E. Nutter-Upham Laura A. Flashman Robert B. Santulli 《Brain imaging and behavior》2009,3(2):212-219
We investigated regional gray matter (GM) reduction as a predictor of judgment ability in 120 non-depressed older adults with
varying degrees of cognitive complaints and/or impairment (including those with MCI and mild AD). Participants underwent neuropsychological
assessment, including the Test of Practical Judgment (TOP-J), a recently developed instrument that evaluates judgment and
problem solving related to safety, medical, social/ethical, and financial issues. Structural MR scanning included T1-weighted
SPGR volumes acquired at 1.5 Tesla. We used voxel-based morphometry to analyze the relationship between GM density and TOP-J
scores, controlling for age, education, gender, intracranial volume, verbal memory, and crystallized knowledge. Consistent
with our hypothesis, judgment ability correlated with GM density in prefrontal regions (left inferior and superior frontal
gyri). Findings extend previous observations of frontal involvement in higher-order cognitive abilities/executive functions
and provide initial validation of the TOP-J’s sensitivity to the integrity of these brain regions in individuals at risk for
dementia.
相似文献
Laura A. RabinEmail: |
658.
659.
M. Swathika Kshitij RB Singh M. Mehala Sadanand Pandey Jay Singh Ravindra Pratap Singh Arunadevi Natarajan 《RSC advances》2022,12(23):14888
In the present work, we evaluated the corrosion inhibition properties of a ligand and mixed metal oxide nanocomposite. The ligand and mixed nickel–cobalt complex were synthesized using 1-naphthoic acid and aminoguanidine with the formulae [C11H7O2(CN4H5)(CN4H6)]·H2O and {Ni–Co[(CH5N4)2(C11H7O2)2]}·H2O, respectively. After their synthesis, physicochemical techniques such as CHNS analysis, infrared and UV-visible spectroscopy, thermal analysis, and X-ray diffraction (XRD) were employed to characterize both the synthesized ligand and nickel–cobalt complex. The metal oxide prepared from the decomposition of the metal complex was also characterized using several techniques to confirm its bonding and structure. In addition, the corrosion inhibition efficiency of the epoxy-ligand and epoxy-NiCo2O4 nanocomposite on mild steel (MS) in 3 M hydrochloric acid (HCl), 1.5 M sulfuric acid (H2SO4), and 0.5 M phosphoric acid (H3PO4) solution was examined and compared using weight loss measurements, Tafel plots, isotherms and electrochemical impedance spectroscopy (EIS). The results from the electrochemical studies disclosed that the epoxy coating of mixed metal oxides with 0.8 ppm concentration yielded excellent corrosion protection. The SEM images of mild steel and mild steel coated with epoxy-ligand/epoxy-NiCo2O4 in HCl confirmed the anti-corrosive behavior of the synthesized compounds. Hence, the as-prepared material can be a next-generation tool for sustainable anti-corrosive coatings.This study reports the synthesis of nano-sized epoxy-NiCo2O4 nanocomposites and their anti-corrosive efficiency to attain sustainable development. 相似文献