全文获取类型
收费全文 | 5757篇 |
免费 | 353篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 169篇 |
妇产科学 | 178篇 |
基础医学 | 767篇 |
口腔科学 | 250篇 |
临床医学 | 419篇 |
内科学 | 1467篇 |
皮肤病学 | 155篇 |
神经病学 | 485篇 |
特种医学 | 210篇 |
外科学 | 804篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 376篇 |
眼科学 | 151篇 |
药学 | 262篇 |
中国医学 | 12篇 |
肿瘤学 | 328篇 |
出版年
2023年 | 43篇 |
2022年 | 96篇 |
2021年 | 256篇 |
2020年 | 131篇 |
2019年 | 204篇 |
2018年 | 233篇 |
2017年 | 140篇 |
2016年 | 138篇 |
2015年 | 189篇 |
2014年 | 227篇 |
2013年 | 292篇 |
2012年 | 451篇 |
2011年 | 463篇 |
2010年 | 270篇 |
2009年 | 221篇 |
2008年 | 339篇 |
2007年 | 349篇 |
2006年 | 321篇 |
2005年 | 290篇 |
2004年 | 256篇 |
2003年 | 236篇 |
2002年 | 211篇 |
2001年 | 90篇 |
2000年 | 81篇 |
1999年 | 102篇 |
1998年 | 38篇 |
1997年 | 36篇 |
1996年 | 26篇 |
1995年 | 26篇 |
1994年 | 14篇 |
1993年 | 19篇 |
1992年 | 29篇 |
1991年 | 35篇 |
1990年 | 32篇 |
1989年 | 27篇 |
1988年 | 20篇 |
1987年 | 33篇 |
1986年 | 20篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 13篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1979年 | 12篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1973年 | 7篇 |
1967年 | 7篇 |
排序方式: 共有6130条查询结果,搜索用时 15 毫秒
81.
82.
Katja M. Gist Brandon M. Henry Santiago Borasino A.K.M. Fazlur Rahman Tennille Webb Kristal M. Hock John S. Kim Benjamin Smood Zachary Mosher Jeffrey A. Alten 《The Annals of thoracic surgery》2021,111(2):655-661
- Download : Download high-res image (170KB)
- Download : Download full-size image
83.
84.
85.
DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus
下载免费PDF全文
![点击此处可从《Journal of oral pathology & medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Aline Fernanda Cruz Renata Gonçalves de Resende Júlio César Tanos de Lacerda Núbia Braga Pereira Leonardo Augusto Melo Marina Gonçalves Diniz Carolina Cavalieri Gomes Ricardo Santiago Gomez 《Journal of oral pathology & medicine》2018,47(1):91-95
Background
The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus.Methods
A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays.Results
Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%).Conclusion
Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. 相似文献86.
87.
Núbia Braga Pereira Ana Carolina de Melo do Carmo Marina Gon?alves Diniz Ricardo Santiago Gomez Dawidson Assis Gomes Carolina Cavalieri Gomes 《Oncotarget》2015,6(12):9679-9685
Background: Ameloblastoma is a locally invasive neoplasm often associated with morbidity and facial deformities, showing increased Epidermal Growth Factor Receptor (EGFR) expression. Inhibition of EGFR was suggested as a treatment option for a subset of ameloblastomas. However, there are resistance mechanisms that impair anti-EGFR therapies. One important resistance mechanism for EGFR-inhibition is the EGFR nuclear localization, which activates genes responsible for its mitogenic effects, such as Cyclin D1.Methods: We assessed EGFR nuclear localization in encapsulated (unicystic, n = 3) and infiltrative (multicystic, n = 11) ameloblastomas and its colocalization with Cyclin D1 by using anti-EGFR and anti-lamin B1 double labeling immunofluorescence analyzed by confocal microscopy. Oral inflammatory fibrous hyperplasia and oral squamous cell carcinoma samples were used for comparison.Results: Twelve cases of ameloblastoma exhibited nuclear EGFR colocalization with lamin B1. This positive staining was mainly observed in the ameloblast-like cells. The EGFR nuclear localization was also observed in control samples. In addition, nuclear EGFR colocalized with Cyclin D1 in ameloblastomas.Conclusions: Nuclear EGFR occurs in ameloblastomas in association with Cyclin D1 expression, which is important in terms of tumor biology clarification and raises a concern about anti-EGFR treatment resistance in ameloblastomas. 相似文献
88.
Mario Martínez-Galdmez Miguel Schüller-Arteaga Jorge Galvn-Fernndez Vladimir Kalousek Ezequiel Petra Boris Pabn Santiago Ortega-Gutirrez Paloma Jimnez-Arribas Carlos Rodríguez-Arias 《Interventional neuroradiology》2021,27(2):230
Flow diverter devices have become a routine first-line option for treatment of an increasing population of intracranial aneurysms at many neurovascular centers. Despite the promising results of flow diverter stents on anterior circulation, incomplete occlusion on the presence of fetal posterior circulation has been described on several reports. Here we describe a novel technical alternative to conventional flow diversion approach for this specific subgroup of aneurysms using the low-profile flow diverter, Silk Vista Baby. The device was selectively placed into the fetal type posterior cerebral artery in half-T configuration for the treatment of a posterior communicating aneurysm using a transcirculation approach through the anterior communicating artery. This represents a useful and effective technique and should be considered when encountering the above-described situation. 相似文献
89.
90.
Barberis María Eugenia Palma Santiago Daniel Gonzo Elio Emilio Bermúdez José María Lorier Marianela Ibarra Manuel Real Juan Pablo 《Pharmaceutical research》2022,39(9):2277-2290
Pharmaceutical Research - 3D printing (3DP) makes it possible to obtain systems that are not achievable with current conventional methods, one of them, sustained release floating systems. Floating... 相似文献