全文获取类型
收费全文 | 3250篇 |
免费 | 260篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 66篇 |
妇产科学 | 37篇 |
基础医学 | 605篇 |
口腔科学 | 24篇 |
临床医学 | 397篇 |
内科学 | 804篇 |
皮肤病学 | 78篇 |
神经病学 | 264篇 |
特种医学 | 39篇 |
外科学 | 340篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 248篇 |
眼科学 | 49篇 |
药学 | 251篇 |
中国医学 | 1篇 |
肿瘤学 | 307篇 |
出版年
2023年 | 26篇 |
2022年 | 39篇 |
2021年 | 110篇 |
2020年 | 58篇 |
2019年 | 86篇 |
2018年 | 114篇 |
2017年 | 67篇 |
2016年 | 94篇 |
2015年 | 104篇 |
2014年 | 130篇 |
2013年 | 176篇 |
2012年 | 276篇 |
2011年 | 310篇 |
2010年 | 159篇 |
2009年 | 149篇 |
2008年 | 251篇 |
2007年 | 241篇 |
2006年 | 236篇 |
2005年 | 244篇 |
2004年 | 216篇 |
2003年 | 171篇 |
2002年 | 165篇 |
2001年 | 13篇 |
2000年 | 5篇 |
1999年 | 12篇 |
1998年 | 20篇 |
1997年 | 17篇 |
1996年 | 8篇 |
1995年 | 18篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有3527条查询结果,搜索用时 531 毫秒
91.
Calland N Albecka A Belouzard S Wychowski C Duverlie G Descamps V Hober D Dubuisson J Rouillé Y Séron K 《Hepatology (Baltimore, Md.)》2012,55(3):720-729
Here, we identify (-)-epigallocatechin-3-gallate (EGCG) as a new inhibitor of hepatitis C virus (HCV) entry. EGCG is a flavonoid present in green tea extract belonging to the subclass of catechins, which has many properties. Particularly, EGCG possesses antiviral activity and impairs cellular lipid metabolism. Because of close links between HCV life cycle and lipid metabolism, we postulated that EGCG may interfere with HCV infection. We demonstrate that a concentration of 50 μM of EGCG inhibits HCV infectivity by more than 90% at an early step of the viral life cycle, most likely the entry step. This inhibition was not observed with other members of the Flaviviridae family tested. The antiviral activity of EGCG on HCV entry was confirmed with pseudoparticles expressing HCV envelope glycoproteins E1 and E2 from six different genotypes. In addition, using binding assays at 4°C, we demonstrate that EGCG prevents attachment of the virus to the cell surface, probably by acting directly on the particle. We also show that EGCG has no effect on viral replication and virion secretion. By inhibiting cell-free virus transmission using agarose or neutralizing antibodies, we show that EGCG inhibits HCV cell-to-cell spread. Finally, by successive inoculation of na?ve cells with supernatant of HCV-infected cells in the presence of EGCG, we observed that EGCG leads to undetectable levels of infection after four passages. CONCLUSION: EGCG is a new, interesting anti-HCV molecule that could be used in combination with other direct-acting antivirals. Furthermore, it is a novel tool to further dissect the mechanisms of HCV entry into the hepatocyte. 相似文献
92.
Robert Bell Reinier Beeuwkes Hans Erik B?tker Sean Davidson James Downey David Garcia-Dorado Derek J. Hausenloy Gerd Heusch Borja Ibanez Masafumi Kitakaze Sandrine Lecour Robert Mentzer Tetsuji Miura Lionel Opie Michel Ovize Marisol Ruiz-Meana Rainer Schulz Richard Shannon Malcolm Walker Jakob Vinten-Johansen Derek Yellon 《Basic research in cardiology》2012,107(6):1-7
93.
94.
95.
96.
97.
98.
99.
Mandl P Naredo E Conaghan PG D'Agostino MA Wakefield RJ Bachta A Backhaus M Hammer HB Bruyn GA Damjanov N Filippucci E Grassi W Iagnocco A Jousse-Joulin S Kane D Koski JM Möller I De Miguel E Schmidt WA Swen WA Szkudlarek M Terslev L Ziswiler HR Ostergaard M Balint PV 《Rheumatology (Oxford, England)》2012,51(1):184-190
100.