总被引：2，自引：0，他引：2  

Rhee TK  Young JY  Larson AC  Haines GK  Sato KT  Salem R  Mulcahy MF  Kulik LM  Paunesku T  Woloschak GE  Omary RA 《Journal of vascular and interventional radiology : JVIR》2007,18(5):639-645

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  总被引：1，自引：0，他引：1  

Murthy R  Brown DB  Salem R  Meranze SG  Coldwell DM  Krishnan S  Nunez R  Habbu A  Liu D  Ross W  Cohen AM  Censullo M 《Journal of vascular and interventional radiology : JVIR》2007,18(4):553-61; quiz 562

Hepatic arterial therapy with yttrium-90 microspheres exploits the avenue provided by the neoplastic microvasculature to deliver high-energy, low-penetrating therapeutic doses of radiation. Variant hepatic arterial anatomy, collateral vessels, and changes in flow dynamics during treatment can affect particle dispersion and lead to nontarget particle distribution and subsequent gastrointestinal morbidity. Awareness of these variances and techniques to prevent gastrointestinal tract microsphere delivery is essential in mitigating this serious complication. Our aim is to increase the understanding of the role of various imaging and preventative techniques in minimizing this undesired effect.  相似文献   

    

Sato KT  Wang D  Lewandowski RJ  Ryu RK  Klein RA  Salem R  Larson AC  Omary RA 《Journal of magnetic resonance imaging : JMRI》2011,34(3):563-569

Purpose:

To investigate the hypothesis that four‐dimensional (4D) transcatheter intraarterial perfusion (TRIP) magnetic resonance imaging (MRI) can quantify immediate perfusion changes after radiofrequency (RF) ablation in rabbit VX2 liver tumors.

Materials and Methods:

Nine New Zealand White rabbits were used to surgically implant VX2 liver tumors. During ultrasound‐guided RF ablation, tumors received either a true or sham ablation. After selective catheterization of the left hepatic artery under x‐ray fluoroscopy, we acquired pre‐ and post‐RF ablation 4D TRIP MR images using 3 mL of 2.5% intraarterial gadopentetate dimeglumine. Two regions‐of‐interest were drawn upon each tumor to generate signal‐intensity time curves. Area under the curve (AUC) was calculated to provide semiquantitative perfusion measurements that were compared using a paired t‐test (α = 0.05). Ablated tissue was visually confirmed on pathology using Evans blue dye.

Results:

Mean AUC perfusion of VX2 tumors for the true ablation group decreased by 92.0% (95% confidence interval [CI]: 83.3%–100%), from 1913 (95% CI: 1557, 2269) before RF ablation to 76.6 (95% CI: 18.4, 134.8) after RF ablation (a.u., P < 0.001). Sham‐ablated tumors demonstrated no significant perfusion changes.

Conclusion:

4D TRIP MRI can quantify liver tumor perfusion reductions in VX2 rabbits after RF ablation. This MRI technique can potentially be used to improve tumor response assessment at the time of RF ablation. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.  相似文献   

    

Henry C Driscoll  Linda Serody  Susan Patrick  Jennifer Maurer  Salem Bensasi  Patricia R Houck  Sati Mazumdar  Eric A Nofzinger  Bethany Bell  Robert D Nebes  Mark D Miller  Charles F Reynolds 《The American journal of geriatric psychiatry》2008,16(1):74-82

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Jannie Pedersen  Mehmet Coskun  Christoffer Soendergaard  Mohammad Salem  Ole Haagen Nielsen 《World journal of gastroenterology : WJG》2014,20(1):64-77

Inflammatory bowel disease(IBD)is a group of chronic disorders of the gastrointestinal tract comprising Crohn’s disease(CD)and ulcerative colitis(UC).Their etiologies are unknown,but they are characterised by an imbalanced production of pro-inflammatory mediators,e.g.,tumor necrosis factor(TNF)-α,as well as increased recruitment of leukocytes to the site of inflammation.Advantages in understanding the role of the inflammatory pathways in IBD and an inadequate response to conventional therapy in a large portion of patients,has over the last two decades lead to new therapies which includes the TNF inhibitors(TNFi),designed to target and neutralise the effect of TNF-α.TNFi have shown to be efficient in treating moderate to severe CD and UC.However,convenient alternative therapeutics targeting other immune pathways are needed for patients with IBD refractory to conventional therapy including TNFi.Indeed,several therapeutics are currently under development,and have shown success in clinical trials.These include antibodies targeting and neutralising interleukin-12/23,small pharmacologic Janus kinase inhibitors designed to block intracellular signaling of several pro-inflammatory cytokines,antibodies targeting integrins,and small anti-adhesion molecules that block adhesion between leukocytes and the intestinal vascular endothelium,reducing their infiltration into the inflamed mucosa.In this review we have elucidated the major signaling pathways of clinical importance for IBD therapy and highlighted the new promising therapies available.As stated in this paper several new treatment options are under development for the treatment of CD and UC,however,no drug fits all patients.Hence,optimisations of treatment regimens are warranted for the benefit of the patients either through biomarker establishment or other rationales to maximise the effect of the broad range of mode-of-actions of the present and future drugs in IBD.  相似文献   

    

Elsayed Abo‐Salem  John C. Fowler  Mehran Attari  Craig D. Cox  Alejandro Perez‐Verdia  Ragesh Panikkath  Kenneth Nugent 《Cardiovascular therapeutics》2014,32(1):19-25

This review aims to clarify the underlying risk of arrhythmia associated with the use of macrolides and fluoroquinolones antibiotics. Torsades de pointes (TdP) is a rare potential side effect of fluoroquinolones and macrolide antibiotics. However, the widespread use of these antibiotics compounds the problem. These antibiotics prolong the phase 3 of the action potential and cause early after depolarization and dispersion of repolarization that precipitate TdP. The potency of these drugs, as potassium channel blockers, is very low, and differences between them are minimal. Underlying impaired cardiac repolarization is a prerequisite for arrhythmia induction. Impaired cardiac repolarization can be congenital in the young or acquired in adults. The most important risk factors are a prolonged baseline QTc interval or a combination with class III antiarrhythmic drugs. Modifiable risk factors, including hypokalemia, hypomagnesemia, drug interactions, and bradycardia, should be corrected. In the absence of a major risk factor, the incidence of TdP is very low. The use of these drugs in the appropriate settings of infection should not be altered because of the rare risk of TdP, except among cases with high‐risk factors.  相似文献   

    

Hannock Tweya  Salem Gugsa  Mina Hosseinipour  Colin Speight  Wingston Ng'ambi  Mphatso Bokosi  Janet Chikonda  Annie Chauma  Patricia Khomani  Malocho Phoso  Tiwonge Mtande  Sam Phiri 《Tropical medicine & international health : TM & IH》2014,19(11):1360-1366

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Chaker Ben Salem  Wafa Saidi  Sofiene Larif  Neila Fathallah  Raoudha Slim  Houssem Hmouda 《Indian journal of pharmacology》2015,47(1):123-124

Allopurinol hypersensitivity syndrome (AHS) is a severe drug reaction. It is characterized by rash, fever, and internal organ involvement. It may present in different clinical forms. We present a case of acute generalized exanthematous pustulosis occurring as a manifestation of AHS.KEY WORDS: Allopurinol, hypersensitivity syndrome, pustulosis  相似文献   

    

Eman Magdy Maher  Ahmed Mahmoud Abdelhaleem Ali  Heba Farouk Salem  Ahmed Abdelbary Abdelrahman 《Drug delivery》2016,23(8):3088-3100

Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was performed using differential scanning calorimetry (DSC), Fourier transform infrared spectrometry (FTIR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). Dispersions with highest equilibrium solubility were formulated as fast dissolving oral films. Modeling and optimization of film formation were undertaken using artificial neural networks (ANNs). The results indicated co-amorphization of OL-ascorbic acid through H-bonding. The co-amorphous dispersions at 1:2 molar ratio showed more than 600-fold increase in solubility of OL. The model optimized fast dissolving film prepared from the dispersion was physically and chemically stable, demonstrated short disintegration time (8.5?s), fast dissolution (97% in 10?min) and optimum tensile strength (4.9 N/cm²). The results of in vivo data indicated high bioavailability (144?ng h/mL) and maximum plasma concentration (14.2?ng/mL) compared with the marketed references. Therefore, the optimized co-amorphous OL-ascorbic acid fast dissolving film could be a valuable solution for enhancing the physicochemical and pharmacokinetic properties of OL.  相似文献   

The Induction of Nitric Oxide by Interleukin-12 and Tumor Necrosis Factor-alpha in Human Natural Killer Cells: Relationship With the Regulation of Lytic Activity   总被引：1，自引：0，他引：1  

Salvucci  Ombretta; Kolb  Jean Pierre; Dugas  Bernard; Dugas  Nathalie; Chouaib  Salem 《Blood》1998,92(6):2093-2102

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