全文获取类型
收费全文 | 14464篇 |
免费 | 1047篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 86篇 |
儿科学 | 414篇 |
妇产科学 | 233篇 |
基础医学 | 2611篇 |
口腔科学 | 304篇 |
临床医学 | 1284篇 |
内科学 | 3179篇 |
皮肤病学 | 401篇 |
神经病学 | 1843篇 |
特种医学 | 577篇 |
外国民族医学 | 1篇 |
外科学 | 1398篇 |
综合类 | 129篇 |
一般理论 | 7篇 |
预防医学 | 870篇 |
眼科学 | 251篇 |
药学 | 824篇 |
中国医学 | 21篇 |
肿瘤学 | 1122篇 |
出版年
2023年 | 75篇 |
2022年 | 157篇 |
2021年 | 283篇 |
2020年 | 221篇 |
2019年 | 314篇 |
2018年 | 359篇 |
2017年 | 235篇 |
2016年 | 334篇 |
2015年 | 363篇 |
2014年 | 484篇 |
2013年 | 631篇 |
2012年 | 953篇 |
2011年 | 1029篇 |
2010年 | 553篇 |
2009年 | 532篇 |
2008年 | 842篇 |
2007年 | 874篇 |
2006年 | 810篇 |
2005年 | 849篇 |
2004年 | 772篇 |
2003年 | 717篇 |
2002年 | 621篇 |
2001年 | 258篇 |
2000年 | 262篇 |
1999年 | 243篇 |
1998年 | 176篇 |
1997年 | 125篇 |
1996年 | 112篇 |
1995年 | 97篇 |
1994年 | 83篇 |
1993年 | 69篇 |
1992年 | 162篇 |
1991年 | 147篇 |
1990年 | 165篇 |
1989年 | 134篇 |
1988年 | 106篇 |
1987年 | 108篇 |
1986年 | 114篇 |
1985年 | 100篇 |
1984年 | 86篇 |
1983年 | 68篇 |
1982年 | 53篇 |
1981年 | 49篇 |
1980年 | 40篇 |
1979年 | 86篇 |
1978年 | 60篇 |
1977年 | 48篇 |
1976年 | 43篇 |
1975年 | 41篇 |
1973年 | 57篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Gregor Domes Markus Heinrichs Jan Gl?scher Christian Büchel Dieter F Braus Sabine C Herpertz 《Neuropsychopharmacology》2007,62(10):1187-1190
BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects. METHODS: In a functional magnetic resonance imaging study using a double-blind, placebo-controlled within-subject design, we measured neural responses to fearful, angry, and happy facial expressions after intranasal application of 24 IU oxytocin compared with placebo. RESULTS: Oxytocin reduced right-sided amygdala responses to all three face categories even when the emotional content of the presented face was not evaluated explicitly. Exploratory whole brain analysis revealed modulatory effects in prefrontal and temporal areas as well as in the brainstem. CONCLUSIONS: Results suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior. 相似文献
52.
Michael Gerharz MD ; Ankev Baranowsky PhD ; Udo Siebolts MD ; Sabine Eming MD ; Roswitha Nischt PhD ; Thomas Krieg PhD ; Claudia Wickenhauser MD 《Wound repair and regeneration》2007,15(1):105-112
Morphometric data based on skin wounding offer important information for the characterization of the phenotype of transgenic mouse models. The goal of this study was the comparison of technical procedures concerning wounding, processing, and evaluation of samples in different mouse strains. The multitissue array technique was used to estimate its adaptability for standardized analysis in wound healing. Skin wounds between days 1 and 14 after wounding were analyzed. The influence of mouse strain (C57BI/6 vs. FVB/N mice), sex, size of the punch biopsies, and preparation of the tissue sections was investigated on 94 mice. The parameters distance between the migration tongues (deltaMT) and surface not covered by epithelium were evaluated to describe the reepithelialization, and the distance between the adnexa was chosen to measure wound contraction. In addition, the techniques to measure the area of granulation tissue (GT) were evaluated. The data illustrate the requirement of standardized conditions for skin wound-healing experiments and demonstrate that histological preparation in serial sections is mandatory to detect slight differences in wound contraction. For the analysis of cellular composition in GT, multitissue arrays are useful tools in wound-healing studies. 相似文献
53.
54.
Lorraine N Clark Eneli Haamer Helen Mejia-Santana Juliette Harris Suzanne Lesage Alexandra Durr Sabine Janin Bs Katja Hedrich Elan D Louis Lucien J Cote Howard Andrews Stanley Fahn Cheryl Waters Blair Ford Steven Frucht William Scott Christine Klein Alexis Brice Hanno Roomere Ruth Ottman Karen Marder 《Movement disorders》2007,22(7):932-937
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows their simultaneous detection. The chip was validated by screening 85 PD cases and 47 controls previously tested for Parkin mutations. Similar genotyping microarrays have been developed for other genetically heterogeneous diseases including age-related macular degeneration. Here, we show the utility of a genotyping array for Parkinson's disease by analysis of 60 subjects from the Genetic Epidemiology of Parkinson Disease (GEPD) study that includes 15 early-onset PD case probands and 45 relatives. 相似文献
55.
Nicole Rotter Hubert Wagner Sabine Fuchshuber Wolfgang J. Issing 《European archives of oto-rhino-laryngology》2003,260(5):254-257
Microcystic adnexal carcinoma is a rare cutaneous neoplasm characterized by slow but locally aggressive growth, which normally does not lead to systemic metastasis. Frequent local recurrences are reported, which are most likely due to insufficient operative technique. We present the fourth case of cervical ipsilateral metastatic microcystic adnexal carcinoma in an otherwise healthy woman. The patient presented with a previously diagnosed but not completely resected microcystic adnexal carcinoma in the area of the right posterior scalp and two palpable ipsilateral lymph nodes. The tumor was resected using intraoperative snap frozen histological evaluation of the resection borders. In the same procedure two lymph nodes were resected from the right neck. The lymph nodes were histologically assessed and showed infiltration by small strains of tumor cells. After exclusion of a second primary tumor, e.g., mammary carcinoma, as the cause for cervical lymph node metastases, we performed a modified radical neck dissection with resection of the sternocleidomastoid muscle and the accessory nerve, which was histologically proven to be perineurally infiltrated by tumor cells. In this second procedure the histological evaluation of the specimen showed no sign of remaining tumor infiltration. After exclusion of distant metastasis the patient was irradiated with 60 Gy. The patient is well 1 year after the initial treatment without signs of recurrence. 相似文献
56.
57.
Bath application of
-fucose and
-fucosyllactose (
F1 increases the potentiation of the population spike amplitude (POP-spike) and the field excitatory postsynaptic potential (fEPSP) after tetanization of the Schaffer collaterals of the rat hippocampus. The ineffective isomers
-fucose and 3-fucosyllactose (3-F1) have no such effect. Since not only the maintenance of long-term potentiation LTP is influenced but also its induction is drastically improved, an effect of the sugars via the formation of glycoproteins but also via different actions on induction mechanisms is discussed. 相似文献
58.
59.
60.
The risk estimates for individual carriers of ten different familial reciprocal translocations detected among 500 couples with reproductive failures are presented. These were established by application of the empirical data analysed by Stengel-Rutkowski et al. (1988) and the guidelines given in Stene & Stengel-Rutkowski (1988). Different risks were estimated for unbalanced offspring at birth or at second trimester prenatal diagnosis for abortions, or stillbirths/early deaths. These risk estimates varied considerably from translocation to translocation. Carriers of five translocations had risks for offspring with single-segment imbalances. The birth risk figures ranged from 0.1% to 13.8%. Carriers of five other translocations had risks for double-segment imbalances with birth risks ranging from 0% to 3.2%. The estimated risk figures were independent of the method of ascertainment. Among the parents of the index cases we found nine maternal carriers and only one paternal carrier. This presentation illustrates the need for individual risk counselling of each carrier with reciprocal translocation regarding further family planning. 相似文献