INTRANASAL LHRH AGONIST TREATMENT FOR INHIBITION OF OVULATION IN WOMEN: CLINICAL ASPECTS

Daily intranasal administration of the potent stimulatory LHRH analogue D-Ser(TBU)⁶-EA¹⁰-LHRH was given to fifty healthy women for 3 months. Twenty-six women received 400 μg LHRH agonist/day and twenty-four women received 600 μg/day. Inhibition of ovulation occurred during 147 of the 150 treatment months. The three presumptively ovulatory cycles were probably the result of initial technical problems with the nasal spray. No pregnancies occurred. Reactivation of corpus luteum with slightly raised progesterone levels in serum at initiation of treatment was observed in six women. During 20 months of treatment the serum progesterone levels were slightly raised, indicating luteinization of follicles or defect luteal phases. Most of the women had menstrual-like bleeding during treatment. Seventeen volunteers had regular bleeding and twenty-three women had oligomenorrhoea. No dysfunctional uterine bleeding occurred, but three women reported spotting. The remaining ten women had amenorrhoea during treatment without any symptoms of oestrogen deficiency. After discontinuation of treatment the women regained ovulatory menstrual cycles after 31 days on average. The treatment was very well accepted by all the women.     

Treatment of mandibular dysfunction: the clinical usefulness of biofeedback in relation to splint therapy

The long-term treatment effects of biofeedback and occlusal splints on mandibular dysfunction were compared. Thirty female patients were randomly divided into two treatment groups. One group had full coverage splints, the other group received biofeedback training. At the re-examinations 1 and 12 months after completion of therapy, the subjective and clinical symptoms were significantly reduced in both groups. No significant differences between the groups were found. A stepwise analysis of regression indicated that biofeedback training may be a useful alternative to splint therapy in cases where night time bruxing is not the dominating feature.     

Fibrinogen and IgG in the hyaline zone in man after orthodontic movement

Abstract – Fibrinogen and IgG were demonstrated in the hyaline zone with direct immunofluorescent staining after orthodontic tooth movement in man. It was suggested that presence of plasma proteins in the hyaline zone contributed to its hyaline appearance. Fibrin and IgG may, furthermore, attract phagocytes and form a network for the reorganization of the necrotic tissue in the hyaline zone.     

Soft-tissue stretching: a possible control factor in craniofacial morphogenesis

abstract – A hypothesis is presented which links posturally induced stretching of the facial soft-tissue layer, craniofacial morphology and airway adequacy into a suggested cycle of factors related to craniofacial morphogenesis.