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111.
Fujioka T Aoyama N Sakai K Miwa Y Kudo M Kawashima J Matsubara Y Miwa J Yakabi K 《Journal of gastroenterology》2012,47(3):276-283
Background
In recent years in Japan, the rate of clarithromycin (CAM) resistance in Helicobacter pylori has risen to around 30%, and the eradication rate with triple therapy [proton pump inhibitor + amoxicillin (AMPC) + CAM] has been trending downward to around 70%. In 2007, rabeprazole (RPZ)-based triple therapy (RPZ + AMPC + CAM: RAC therapy) was approved in Japan, and a large-scale nationwide study was therefore initiated to evaluate the efficacy and safety of RAC therapy in clinical practice. 相似文献112.
Hiroyuki Matsuoka Gen-ichiro Sano Ryuta Hattori Hiroyuki Tomita Daisuke S. Yamamoto Makoto Hirai 《Tropical Medicine and Health》2012,40(2):47-52
It has been proposed that transgenic mosquitoes can be used as a “flying syringe” for infectious disease control. We succeeded in generating a transgenic (TG) mosquito, Anopheles stephensi, excreting and discharging DsRed in saliva. DsRed was deposited on the membrane where the TG mosquito probed with its proboscis. Repeated feeding by the TG mosquitoes induced anti-DeRed as well as anti-SG antibodies in mice. This indicates that the TG mosquitoes can immunize the animal. Moreover, in this report, we employed a pre-immunization method before exposing mice to the TG mosquitoes. We injected DsRed to mice to prepare memory B cells and exposed the mice to bites by the TG mosquitoes excreting DsRed. The mice produced a higher titer of antibody to DsRed, suggesting that the bites from TG mosquitoes act as a booster and that primary immunization with a vaccine protein and exposure to TG mosquitoes excreting the vaccine protein in the saliva produces a synergistic effect. 相似文献
113.
Fujii W Kohno M Ishino H Nakabayashi A Fujioka K Kida T Nagahara H Murakami K Nakamura K Seno T Yamamoto A Kawahito Y 《Modern rheumatology / the Japan Rheumatism Association》2012,22(4):630-634
We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept. 相似文献
114.
Masaki Fujioka Tohru Fujii Akiyoshi Hirano 《Journal of plastic surgery and hand surgery》2013,47(3):259-263
We describe two cases in which three-dimensional miniplates broke after bilateral sagittal split osteotomy. The miniplates broke vertically and the cause was suspected to be excessive shear force on the osteotomy line because of unstable occlusion. In patients with unstable postoperative occlusions the osteosynthesis should be bicortical. 相似文献
115.
116.
Hiroaki Hanada Junko Imanaga Aoi Yoshiiwa Tomoya Yoshikawa Yoshihiro Tanaka Jusen Tsuru Ayako Inoue Yoshinobu Ishitobi Shizuko Okamoto Masayuki Kanehisa Yoshihiro Maruyama Taiga Ninomiya Haruka Higuma Koichi Isogawa Tsuyoshi Kawasaki Toshio Fujioka Jotaro Akiyoshi 《International journal of geriatric psychiatry》2013,28(7):756-765
117.
Yasuyuki Taki Benjamin Thyreau Shigeo Kinomura Kazunori Sato Ryoi Goto Kai Wu Ryuta Kawashima Hiroshi Fukuda 《Human brain mapping》2013,34(9):2292-2301
The aim of this study was to analyze correlations among the annual rate of gray matter volume change, age, gender, and cerebrovascular risk factors in 381 healthy community‐dwelling subjects with a large age range by applying a longitudinal design over 6 years using brain magnetic resonance images (MRIs). Brain MRI data were processed with voxel‐based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. The annual rate of regional gray matter volume change showed significant positive correlations with age in several regions, including the bilateral temporal pole, caudate nucleus, ventral and dorsolateral prefrontal cortices, insula, hippocampus, and temporoparietal cortex, whereas significant negative correlations with age were observed in several regions including the bilateral cingulate gyri and anterior lobe of the cerebellum. Additionally, a significant age‐by‐gender interaction was found for the annual rate of regional gray matter volume change in the bilateral hippocampus. No significant correlations were observed between the annual rate of regional gray matter volume change and body mass index or systolic blood pressure. A significant positive correlation between the annual rate of gray matter volume change and age indicates that the region shows not linear but accelerated gray matter loss with age. Therefore, evaluating the annual rate of the gray matter volume change with age in healthy subjects is important in understanding how gray matter volume changes with aging in each brain region and in anticipating what cognitive functions are likely to show accelerated decline with aging. Hum Brain Mapp 34:2292–2301, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
118.
Horinouchi Tomoko Maeyama Kaori Nagai Masashi Mizobuchi Masami Takagi Yasuko Okada Yuka Kato Takeshi Nishimura Mio Kawasaki Yoko Yoshioka Mieko Takada Satoshi Matsumoto Hisayuki Nakamachi Yuji Saegusa Jun Fukushima Sachiyo Fujioka Kazumichi Tomioka Kazumi Nagase Hiroaki Nozu Kandai Iijima Kazumoto Nishimura Noriyuki 《Journal of autism and developmental disorders》2022,52(2):483-489
Journal of Autism and Developmental Disorders - Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the... 相似文献
119.
Saito Masaya Saito Ayano Abe Fumito Imaizumi Chihiro Kaga Hajime Sawamura Masato Nara Mizuho Ozawa Masatoyo Sato Ryuta Nakayama Takahiro Okuyama Shin Masai Rie Ohtani Hiroshi Komatsuda Atsushi Wakui Hideki Takahashi Naoto 《Clinical and experimental nephrology》2022,26(8):760-769
Clinical and Experimental Nephrology - We determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic... 相似文献
120.
Ken Fujioka Thomas Sparre Lily Yong-Hui Sun Susanne Krogsgaard Robert F. Kushner 《Journal of diabetes science and technology》2016,10(1):164-174