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Konobu T Hata M Imanishi M Inada Y Murao Y Okuchi K Miyamoto S 《Kyobu geka. The Japanese journal of thoracic surgery》2000,53(12):1049-1051
A case of penetrating lung and diaphragmatic injuries with no abnormal findings of chest X-ray is reported. A 76-year-old man was admitted to our hospital due to penetrating chest trauma. A simple X-ray film of the chest on admission revealed no abnormal finding. An emergency operation was performed. On exploring the back open wound, we found a laceration of 7 cm in diameter in the right diaphragm and lung laceration. Then we repaired primarily with absorbable material. The postoperative course was uneventful, and the patient was discharged 12 days later. Penetrating truncal traumas can result in diaphragmatic injury. Sometimes the clinical and roentgenographic findings are unreliable. If the diagnosis is missed, a diaphragmatic injury may occur delayed diaphragmatic hernias within hours to years. Accordingly, initial wound exploration are important for the diagnosis of diaphragmatic injury in avoiding serious complications. 相似文献
123.
Junko Miyamoto Hiroshi Asanuma Hideo Nakai Tomonobu Hasegawa Hajime Nawata Yukihiro Hasegawa 《Clinical Pediatric Endocrinology》2006,15(4):151-162
The prevalence of abnormalities in androgen receptor gene (AR) among patients with
ambiguous genitalia is unknown. Moreover, endocrinological data from prepubertal patients
with AR mutation are very limited. Thus, the aim of this study was to examine the
prevalence of abnormalities in AR among patients with both ambiguous genitalia, which was
defined as a combination of two or more genital abnormalities (i.e. hypospadias,
microphallus (penile length < 25 mm), hypoplastic scrotum, bifid scrotum, undescended
testis) in this study, and normal to elevated T levels. We also compared the
endocrinological data of prepubertal patients with AR mutation and ambiguous genitalia
with that of those without the AR mutation. We screened 26 Japanese prepubertal 46,XY
patients (five from three families were included) with both ambiguous genitalia and normal
to elevated T levels. Mutations in AR were found in three (two of the three were related).
Among the 23 patients without mutation in AR, the steroid 5-alpha-reductase 2 gene
(SRD5A2) was also examined in eight patients with elevated T/dehydrotestosterone ratio
after the hCG (>10) or with undervirilized family members. No mutation in SRD5A2 was
found. Characteristics of the three patients with mutation in AR were compared with the 23
patients without mutation. In two patients, basal T levels (0.3, 0.2 ng/ml) and peak T
levels after the hCG tests (8.3, 8.5 ng/ml) tended to be higher, and the peak LH/ peak FSH
ratios after the GnRH tests (4.6, 4.0) were higher than in patients without mutation, at
the ages of 1 yr and 9 mo and 3 yr and 8 mo, respectively. In conclusion, an abnormality
in either AR or SRD5A2 was not common among patients with ambiguous genitalia and normal
testosterone secretion. Elevated peak LH/peak FSH ratio (≥4) after the GnRH test in
addition to detectable basal T levels and elevated peak T levels after the hCG test may
infer AR abnormality in prepubertal patients with ambiguous genitalia at the age of one
and over, although further study is needed, because our data were limited. 相似文献
124.
Activation of the amyloid beta-protein precursor, secretary pathway through alpha-secretase has been reported to increase the secretion of neuroprotective amyloid precursor protein and preclude the formation of amyloid beta-protein. Activation of protein kinase C has been shown to accelerate this secretory pathway. These results prompted us to focus on a potential links between protein kinase C and the amyloid beta-protein-related pathology of Alzheimer disease (AD). Although protein kinase C is reported to occur in senile plaques, its catalytic activity has not been investigated. As the phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) has been used as a marker for activation of protein kinase C in vivo, we examined its phosphorylation in brain tissues obtained from seven AD patients and five non-demented subjects using an antibody that specifically recognized MARCKS phosphorylated by protein kinase C. Phosphorylation of MARCKS in cortical neurons in AD brains was weaker than that in control brains. Interestingly, however, phosphorylation of MARCKS was detected in microglia and dystrophic neurites within neuritic plaques, a mature form of amyloid beta-protein deposits. These results suggest that protein kinase C alteration is associated with AD pathology and that protein kinase C is activated in microglia and dystrophic neurites by amyloid beta-protein in AD brains. 相似文献
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