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101.
Perepechaeva ML Seredina TA Sidorova YA Pivovarova EN Markel AL Lyakhovich VV Grishanova AY 《Biomedical and environmental sciences : BES》2017,30(4)
<正>We studied effects of nutrient quercetin on cytochromes’Р450 1А(CYP1A)activities(measured spectrofluorimetrically using 7-ethoxy-resorufin for CYP1A1 and 7-methoxy-resorufin for CYP1A2 as substrates),on mR NA levels(measured by RT-PCR),and on DNA-binding activities(evaluated by an electrophoretic mobility shift assay)of proteins regulating CYP1A expression in untreated and benzo(α)pyrene(Ba P)-treated rats.Wistar rats 相似文献
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(1) Recurrent parotitis is probably caused by a congenital abnormality of the salivary gland ducts with recurrent attacks of ascending infection, perhaps aided by dehydration. The parotid gland is predominantly affected probably because of its lower rate of secretion compared with the submandibular gland. (2) The condition mainly affects children between the ages of 3 and 6, with males being more commonly affected. The symptoms peak in the first year of school, and usually, but not invariably, begin to subside at puberty. By the age of 22, most patients are completely symptom-free. When the disease starts after puberty, females are predominantly affected. (3) Ultrasound is the appropriate initial investigation, and is usually supplemented by sialography. The sialography may itself cause a resolution of symptoms. (4) Treatment is conservative in the first instance, and an expectant policy is indicated. More aggressive treatment is justified only for those adults with persistent problems. This may be parotid duct ligation, parotidectomy, or tympanic neurectomy, depending upon the preference and experience of the treating physician. 相似文献
104.
Metaphyseal growth arrest lines are seen in children who experience significant physical stress such as infection or malnutrition over a sufficient period of time. These lines have not been reported previously in children with psychosocial short stature (PSS). Two boys and a girl with PSS with metaphyseal growth arrest lines on skeletal radiographs at the time of maximal stress in their homes are described. All three had reversible growth hormone insufficiency during admission, which is pathognomic for PSS. Multiple growth arrest lines in the distal end of the radius or vertebrae should alert clinicians to an alternative diagnosis in a child with growth hormone insufficiency. This may provide a clue to the diagnosis of occult PSS. 相似文献
105.
N. E. Kushlinskii V. V. Delektorskaya V. V. Mochal’nikova Li Sini A. A. Yurchenko A. B. Ryabov I. S. Stilidi 《Bulletin of experimental biology and medicine》2008,146(6):786-790
Immunohistochemical analysis of the expression and distribution of nm23 protein and biochemical analysis of the main components
of plasminogen activation system in tumors were carried out in stomach cancer patients. The data indicate that the expression
of nm23 protein in malignant epithelial gastric tumors is heterogeneous, characterized by cytoplasmic and nuclear immunoreactivity.
Reduced expression of the marker is more typical of poorly or undifferentiated tumors. The expression of nm23 protein positively
correlated with tPA level (r
s = 0.4; p = 0.01) and did not correlate with the content of uPA and PAI-1 in tumors. High PAI-1 values in tumors (>0.5 ng/mg protein)
significantly correlated with lower 3-year overall survival of stomach cancer patients. These data confirm the role of the
studied proteins in invasion and metastases of malignant tumors and suggest a relationship between changes in the expression
of nm23 protein and mechanisms of stomach cancer progress.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 686–690, December, 2008 相似文献
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Biju Gopalakrishnan VV Ashraf Praveen Kumar Krishna Kiran 《Annals of Indian Academy of Neurology》2014,17(2):222-224
Young onset dementia is a challenge. We describe a case, where a patient presented with psychosis, dementia and MRI showing pulvinar sign, all of this typical of variant Cruetzfelt Jacob disease (CJD). Subsequent investigations lead to the diagnosis of a treatable illness and patient was improved and MRI sign reversed, underlining again the importance of search needed for treatable diseases in any “typical” case of fatal illness. 相似文献
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