全文获取类型
收费全文 | 25254篇 |
免费 | 1622篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 388篇 |
儿科学 | 693篇 |
妇产科学 | 422篇 |
基础医学 | 3457篇 |
口腔科学 | 372篇 |
临床医学 | 2297篇 |
内科学 | 4946篇 |
皮肤病学 | 909篇 |
神经病学 | 2400篇 |
特种医学 | 874篇 |
外国民族医学 | 2篇 |
外科学 | 4700篇 |
综合类 | 220篇 |
一般理论 | 6篇 |
预防医学 | 1661篇 |
眼科学 | 625篇 |
药学 | 1543篇 |
中国医学 | 39篇 |
肿瘤学 | 1385篇 |
出版年
2023年 | 127篇 |
2022年 | 131篇 |
2021年 | 362篇 |
2020年 | 231篇 |
2019年 | 315篇 |
2018年 | 665篇 |
2017年 | 451篇 |
2016年 | 582篇 |
2015年 | 615篇 |
2014年 | 619篇 |
2013年 | 981篇 |
2012年 | 1666篇 |
2011年 | 1888篇 |
2010年 | 868篇 |
2009年 | 695篇 |
2008年 | 1303篇 |
2007年 | 1480篇 |
2006年 | 1387篇 |
2005年 | 1366篇 |
2004年 | 1304篇 |
2003年 | 1189篇 |
2002年 | 1126篇 |
2001年 | 681篇 |
2000年 | 647篇 |
1999年 | 619篇 |
1998年 | 200篇 |
1997年 | 172篇 |
1996年 | 106篇 |
1995年 | 121篇 |
1994年 | 122篇 |
1992年 | 256篇 |
1991年 | 295篇 |
1990年 | 240篇 |
1989年 | 238篇 |
1988年 | 203篇 |
1987年 | 217篇 |
1986年 | 201篇 |
1985年 | 216篇 |
1984年 | 141篇 |
1983年 | 142篇 |
1981年 | 98篇 |
1979年 | 141篇 |
1978年 | 123篇 |
1977年 | 99篇 |
1976年 | 101篇 |
1975年 | 123篇 |
1974年 | 123篇 |
1973年 | 103篇 |
1972年 | 113篇 |
1971年 | 100篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
The determination of loss of bone mineral in an early stage of development is important. At the present time there exists
no noninvasive or nonradiological methods which can be used for routine checks. An alternative method to obtain information
about mineral content of bone is to measure the mechanical properties. A new method to measure the mechanical properties of
long bones by means of the dispersion analysis of flexural waves is proposed. To be independent of the frequency spectrum
of the impact pulse, the phase velocities were calculated from the signals of two accelerometers placed in vivo on the tibia.
This method has the advantage that the velocities can be calculated for a frequency range. The results from this method were
compared with the results from a well established measurement method for bone mineral content. Both methods were applied to
43 subjects selected in such a way that a broad range of bone mineral values was covered. The results imply that the proposed
method can be used to test the mechanical properties of long bones. 相似文献
52.
53.
The mechanisms by which adreno-corticoid hormones regulate Na+,K(+)-ATPase in adult kidney were studied in adrenalectomized (Adx) rats. Five days after adrenalectomy, Na+,K(+)-ATPase activity was significantly reduced in the renal cortex homogenate (C = 13.0 +/- 0.8 vs. Adx = 7.1 +/- 0.7 mumol Pi mg-1 protein h-1) and in renal microsomes (C = 30.3 +/- 1.9 vs Adx = 14.6 +/- 1.3 mumol Pi mg-1 protein h-1). Glucocorticoid replacement treatment of adrenalectomized rats with betamethasone (20 micrograms kg-1 body wt twice daily for 5 days) effectively counteracted the observed reduction in Na+,K(+)-ATPase activity. In cortical homogenate the protein level of alpha 1 and beta 1 subunits measured in immunoblots was not significantly different in Adx and control rats, indicating that 5 days after adrenalectomy the alpha 1 and beta 1 subunits were present in renal cortical cells to almost normal extent but could not be assembled into a transmembrane functional unit. In support of this conclusion we found that the protein level of both the alpha 1 and beta 1 subunits was significantly lower (P less than 0.001 for both subunits) in microsomes from Adx than in control rats. The mRNA abundance for alpha 1 and beta 1 subunits were not lower in Adx as compared to control rats 1 and 5 days after surgery. However, if Adx rats were given a single dose of betamethasone (600 micrograms kg-1 body wt), a significant 2-fold increase in both alpha 1 and beta 1 mRNAs was observed (P less than 0.05 for both subunits).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
54.
W J Muir D M St Clair D H Blackwood H M Roxburgh I Marshall 《Psychological medicine》1992,22(3):573-580
Smooth pursuit eye movements to a sinusoidally moving target were recorded using the electro-oculogram in 49 subjects with bipolar disorder, 19 with major depressive disorder and 61 with definite schizophrenia, and compared with 145 normal controls. The signals were analysed in the frequency domain to yield a signal to noise ratio that is known to relate to accuracy of smooth pursuit. Smooth pursuit was found to be significantly poorer in schizophrenics than in bipolars, major depressed or controls. Eye-tracking performance was independent of the effects of neuroleptics, tricyclic antidepressants or lithium, and was not altered by the severity of depression in the affective psychoses. There was a small, but significant worsening of smooth pursuit with age in controls and schizophrenics, but this did not account for the group differences. The results support the view that among the major psychoses eye-tracking dysfunction is specific to schizophrenia. 相似文献
55.
Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. 总被引:21,自引:0,他引:21
Heike A Bischoff Hannes B St?helin Walter Dick Regula Akos Margrith Knecht Christian Salis Matthias Nebiker Robert Theiler Michael Pfeifer Bettina Begerow Robert A Lew Martin Conzelmann 《Journal of bone and mineral research》2003,18(2):343-351
Specific receptors for vitamin D have been identified in human muscle tissue. Cross-sectional studies show that elderly persons with higher vitamin D serum levels have increased muscle strength and a lower number of falls. We hypothesized that vitamin D and calcium supplementation would improve musculoskeletal function and decrease falls. In a double-blind randomized controlled trial, we studied 122 elderly women (mean age, 85.3 years; range, 63-99 years) in long-stay geriatric care. Participants received 1200 mg calcium plus 800 IU cholecalciferol (Cal+D-group; n = 62) or 1200 mg calcium (Cal-group; n = 60) per day over a 12-week treatment period. The number of falls per person (0, 1, 2-5, 6-7, >7 falls) was compared between the treatment groups. In an intention to treat analysis, a Poisson regression model was used to compare falls after controlling for age, number of falls in a 6-week pretreatment period, and baseline 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D serum concentrations. Among fallers in the treatment period, crude excessive fall rate (treatment - pretreatment falls) was compared between treatment groups. Change in musculoskeletal function (summed score of knee flexor and extensor strength, grip strength, and the timed up&go test) was measured as a secondary outcome. Among subjects in the Cal+D-group, there were significant increases in median serum 25-hydroxyvitamin D (+71%) and 1,25-dihydroxyvitamin D (+8%). Before treatment, mean observed number of falls per person per week was 0.059 in the Cal+D-group and 0.056 in the Cal-group. In the 12-week treatment period, mean number of falls per person per week was 0.034 in the Cal+D-group and 0.076 in the Cal-group. After adjustment, Cal+D-treatment accounted for a 49% reduction of falls (95% CI, 14-71%; p < 0.01) based on the fall categories stated above. Among fallers of the treatment period, the crude average number of excessive falls was significantly higher in the Cal-group (p = 0.045). Musculoskeletal function improved significantly in the Cal+D-group (p = 0.0094). A single intervention with vitamin D plus calcium over a 3-month period reduced the risk of falling by 49% compared with calcium alone. Over this short-term intervention, recurrent fallers seem to benefit most by the treatment. The impact of vitamin D on falls might be explained by the observed improvement in musculoskeletal function. 相似文献
56.
Axel Stäbler M.D. Richard G. H. Baumeister M.D. Ulrike Szeimies Ulrich Fink M.D. Hermann Berger M.D. 《Skeletal radiology》1994,23(2):103-106
Post-traumatic ulnar carpal translocation is a rare, severe ligamentous injury to the wrist. Radiologic findings include widening of the radiocarpal joint space at the radial styloid process and ulnar displacement of the carpus. Less than 50% of the lunate articulates with the radius in the neutral position; the lunate is tilted dorsally with palmar subluxation due to a ruptured radioscapholunate (RSL) ligament. This malposition should be called rotatory palmar subluxation of the lunate (RPSL), by analogy to rotatory subluxation of the scaphoid (RSS). In contrast to dorsiflexed intercalated segment instability (DISI), in RPSL the RSL ligament is ruptured and, in the majority of cases, the scapholunate ligament remains intact. A prompt diagnosis should lead to successful treatment. 相似文献
57.
H P Ammon P H Müller M Eggstein C Wintermantel B Aigner H Safayhi M Stützle W Renn 《Arzneimittel-Forschung》1992,42(5):642-645
Thiols have been shown to be related to insulin secretion and to uptake of glucose into tissues. In the present study the effects of i.v. administration of acetylcysteine (N-acetylcysteine, NAC, CAS 616-91-1) on glucose consumption and plasma free thiols were studied in young healthy volunteers during hyperglycemic clamp. NAC (0.5-2.0 mg/kg) significantly increased glucose consumption. This effect was not obvious at higher doses of NAC. Plasma free NAC depended on the dose of NAC injected. The t1/2 of NAC was 11 min. NAC produced significant increases of plasma cysteine concentrations, and a slight but insignificantly increase of plasma glutathione. These data suggest that a moderate increase in plasma thiols augments glucose consumption during hyperglycemic clamp. 相似文献
58.
In the present studies, arterial lipid metabolism was evaluated in the spontaneously hyperlipidemic obese Zucker rat (fa/fa), the lean Zucker rat (Fa/-), and the Sprague-Dawley (SD) rat. Mean serum cholesterol levels in the obese Zucker, lean Zucker and SD rats were 216 +/- 18 mg/dl, 145 +/- 14 mg/dl and 84 +/- 5 mg/dl, respectively. Arterial cholesterol content was in the same rank order as plasma cholesterol and ranged from a mean of 2.23 +/- 0.10 mg/gm wet wt. in the obese rats to 1.36 +/- 0.04 mg/gm wet wt. in the SD rats. The increased arterial sterol in the obese rats was associated with increased lipid metabolism activity. The in vitro incorporation of [14C]oleate into arterial cholesteryl esters was increased 3-4-fold (P less than 0.01) and incorporation into phospholipids and triglycerides was also elevated (P less than 0.001 and P less than 0.01, respectively). The arterial sterol content and arterial lipid metabolism pattern observed in obese Zucker rat aortas are similar to those found in vessels of other species undergoing atherogenic change. 相似文献
59.
60.
Use of stereotactic PET images in dosimetry planning of radiosurgery for brain tumors: clinical experience and proposed classification. 总被引:13,自引:0,他引:13
Marc Levivier Nicolas Massager David Wikler José Lorenzoni Salvador Ruiz Daniel Devriendt Philippe David Fran?oise Desmedt Stéphane Simon Paul Van Houtte Jacques Brotchi Serge Goldman 《Journal of nuclear medicine》2004,45(7):1146-1154
We developed a technique that allows the routine integration of PET in stereotactic neurosurgery, including radiosurgery. We report our clinical experience with the combined use of metabolic (i.e., PET) and anatomic (i.e., MRI and CT) images for the radiosurgical treatment of brain tumors. We propose a classification describing the relative role of the information provided by PET in this multimodality image-guided approach. METHODS: Between December 1999 and March 2003, 57 patients had stereotactic PET as part of their image acquisition for the planning of gamma knife radiosurgery. Together with stereotactic MRI and CT, stereotactic PET images were acquired on the same day using either (18)F-FDG or (11)C-methionine. PET images were imported in the planning software for the radiosurgery dosimetry, and the target volume was defined using the combined information of PET and MRI or CT. To analyze the specific contribution of the PET findings, we propose a classification that reflects the strategy used to define the target volume. RESULTS: The patients were offered radiosurgery with PET guidance when their tumor was ill-defined and we anticipated some limitation of target definition on MRI alone. This represents 10% of the radiosurgery procedures performed in our center during the same period of time. There were 40 primary brain lesions, 7 metastases, and 10 pituitary adenomas. Abnormal PET uptake was found in 62 of 72 targets (86%), and this information altered significantly the MRI-defined tumor in 43 targets (69%). CONCLUSION: The integration of PET in radiosurgery provides additional information that opens new perspectives for the optimization of the treatment of brain tumors. 相似文献