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61.
M C Hirst S J Knight M V Bell M Super K E Davies 《Clinical science (London, England : 1979)》1992,83(3):255-264
An amplification of a highly unstable DNA element has been identified at the fragile X locus in Xq27.3. This sequence appears to be both the source of the primary mutation causing the fragile X syndrome, apparently having its causative effect through the methylation of the FMR-1 HTF island and the region of cytogenetic fragility. The direct analysis of the genotype of carrier and affected individuals can be used as a direct diagnosis tool which will improve both the accuracy and speed of diagnosis. The identification of hereditary unstable DNA in a disease with such a wide level of non-penetrance and variable phenotype may give clues as to the basis of non-penetrance in other human genetic disorders. 相似文献
62.
In the present studies, arterial lipid metabolism was evaluated in the spontaneously hyperlipidemic obese Zucker rat (fa/fa), the lean Zucker rat (Fa/-), and the Sprague-Dawley (SD) rat. Mean serum cholesterol levels in the obese Zucker, lean Zucker and SD rats were 216 +/- 18 mg/dl, 145 +/- 14 mg/dl and 84 +/- 5 mg/dl, respectively. Arterial cholesterol content was in the same rank order as plasma cholesterol and ranged from a mean of 2.23 +/- 0.10 mg/gm wet wt. in the obese rats to 1.36 +/- 0.04 mg/gm wet wt. in the SD rats. The increased arterial sterol in the obese rats was associated with increased lipid metabolism activity. The in vitro incorporation of [14C]oleate into arterial cholesteryl esters was increased 3-4-fold (P less than 0.01) and incorporation into phospholipids and triglycerides was also elevated (P less than 0.001 and P less than 0.01, respectively). The arterial sterol content and arterial lipid metabolism pattern observed in obese Zucker rat aortas are similar to those found in vessels of other species undergoing atherogenic change. 相似文献
63.
Femke M van de Water Johanna M Boleij Janny G P Peters Frans G M Russel Rosalinde Masereeuw 《European journal of pharmaceutical sciences》2007,30(1):36-44
The activity of P-glycoprotein (Pgp/MDR1/ABCB1) and multidrug resistance proteins (MRP/ABCC) influence the pharmacokinetics and bioavailability of many drugs. Few suitable cell lines for the study of drug transport exist. Additional non-human cell lines may help clarify species differences and contribute to the current knowledge of drug transport. The aim of the present study was to characterize three rat epithelial cell lines for transporter expression and activity. Transporter expression was assessed in intestinal IEC-6 and renal GERP and NRK-52E cells using RT-PCR and Western blot analysis. Pgp and Mrp transport activity were analyzed by measuring calcein accumulation and glutathione-S-bimane efflux, respectively. The three cell lines showed Pgp expression and Pgp-dependent transport, both decreasing with culture time after reaching confluency. Besides Pgp, cells expressed Mrp1, Mrp3, Mrp4, and Mrp5, while Mrp2 and Mrp6 were absent. In addition, they showed temperature- and Mrp-dependent efflux of glutathione-S-bimane. Exposure to a panel of different inhibitors showed that this efflux was probably mediated by Mrp4. In conclusion, the three rat epithelial cell lines investigated showed Pgp and Mrp expression and transport. Mrp dependent transport was most likely mediated by Mrp4. In future, these cell lines may be used as in vitro models to study drug transport. 相似文献
64.
Two recently published multicentre trials have confirmed the overall benefit of carotid endarterectomy in symptomatic patients with severe carotid artery disease. The key to improving further the long-term advantages of carotid endarterectomy, however, remains the continued reduction of the initial operative risk. While the principal responsibility for this continues to be borne by the surgeon, specifically in reducing technical error, the time is perhaps approaching when he or she might also be able to apply some of the recent advances in cerebrovascular research to reduce operative morbidity still further in the future. This article summarizes the aetiology and pathophysiology of operation-related neurological deficits and reviews current approaches towards intraoperative monitoring, cerebral protection and assessment of quality control. 相似文献
65.
N. London J. Swales K. Hollinrake P. Bell A. Heagerty 《Postgraduate medical journal》1992,68(806):976-977
We describe the occurrence of primary hyperaldosteronism in two sisters. Although this is only the second published report of familial Conn''s syndrome, it does have implications for the relatives of patients with Conn''s syndrome and these are discussed. 相似文献
66.
D. S. H. Bell 《Diabetologia》2007,50(3):695
67.
68.
Susan Bell 《The Journal of neuroscience nursing》2004,36(4):195-199
Germinomas are the most common type of germ cell tumor occurring commonly before the second decade of life. Because of the radiosensitivity of germinomas, traditional treatment following diagnosis has been conventional radiotherapy. The desire to defer radiotherapy to avoid the delayed neurocognitive effects has led researchers to investigate the use of up front chemotherapy. A major limitation in using chemotherapy for brain tumors has been the inability to deliver drugs across the blood brain barrier. The blood brain barrier consortium has developed chemotherapy protocols for patients with malignant brain tumors through the use of reversible osmotic opening of the blood brain barrier. While the patient is under general anesthesia, osmotic opening or disruption is achieved by a 30-second intracarotid infusion of mannitol. The mannitol infusion is followed by both intraarterial and intravenous chemotherapy. By administering chemotherapy in conjunction with blood brain barrier disruption, drug delivery to the tumor and the brain around tumor is increased. 相似文献
69.
The introduction of bisphosphonates has increased in the last decade following their indication for metastatic bone diseases,
osteoporosis, hypercalcaemia of malignancy and Paget’s disease. Although bisphosphonates have been used clinically for more
than three decades there have been no documented long-term complications of their effects on the jaws until recently, where
there is now growing evidence of the influence of bisphosphonates on osteonecrosis of the jaws. The aim of this paper is to
report a case of this newly described complication, to review this phenomenon, including the clinical implications and to
reiterate current clinical guidelines for management of patients in which bisphosphonate therapy is indicated. To the best
of our knowledge this is the first reported case of bisphosphonate-induced necrosis of the jaw in South Africa. 相似文献
70.
Diana Bell Yi-Jue Zhao Pulivarthi H. Rao Randal S. Weber Adel K. El-Naggar 《Head and neck pathology》2007,1(2):165-168
We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration
by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole
structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development
of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas
are highlighted and discussed. 相似文献