全文获取类型
收费全文 | 4939篇 |
免费 | 208篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 127篇 |
妇产科学 | 84篇 |
基础医学 | 620篇 |
口腔科学 | 47篇 |
临床医学 | 365篇 |
内科学 | 1347篇 |
皮肤病学 | 65篇 |
神经病学 | 558篇 |
特种医学 | 206篇 |
外科学 | 712篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 117篇 |
眼科学 | 49篇 |
药学 | 346篇 |
中国医学 | 4篇 |
肿瘤学 | 447篇 |
出版年
2023年 | 28篇 |
2022年 | 45篇 |
2021年 | 75篇 |
2020年 | 55篇 |
2019年 | 56篇 |
2018年 | 77篇 |
2017年 | 45篇 |
2016年 | 59篇 |
2015年 | 74篇 |
2014年 | 99篇 |
2013年 | 109篇 |
2012年 | 190篇 |
2011年 | 215篇 |
2010年 | 118篇 |
2009年 | 128篇 |
2008年 | 217篇 |
2007年 | 236篇 |
2006年 | 215篇 |
2005年 | 225篇 |
2004年 | 206篇 |
2003年 | 189篇 |
2002年 | 194篇 |
2001年 | 192篇 |
2000年 | 189篇 |
1999年 | 165篇 |
1998年 | 53篇 |
1997年 | 37篇 |
1996年 | 42篇 |
1994年 | 39篇 |
1993年 | 32篇 |
1992年 | 142篇 |
1991年 | 118篇 |
1990年 | 130篇 |
1989年 | 128篇 |
1988年 | 130篇 |
1987年 | 123篇 |
1986年 | 109篇 |
1985年 | 98篇 |
1984年 | 59篇 |
1983年 | 60篇 |
1981年 | 29篇 |
1979年 | 41篇 |
1978年 | 24篇 |
1977年 | 24篇 |
1972年 | 25篇 |
1970年 | 32篇 |
1969年 | 35篇 |
1968年 | 25篇 |
1967年 | 28篇 |
1966年 | 26篇 |
排序方式: 共有5175条查询结果,搜索用时 23 毫秒
101.
102.
103.
Y Matsuoka D Nishi Y Tanima M Itakura M Kojima K Hamazaki H Noguchi T Hamazaki 《Translational psychiatry》2015,5(7):e596
Our open-label pilot study showed that supplementation with docosahexaenoic acid (DHA) increased serum brain-derived neurotrophic factor (BDNF) levels and that there might be an association between changes in serum BDNF levels and reduced psychological distress. Animal research has indicated that a DHA-enriched diet increases BDNF in the brain. In this randomized double-blind controlled trial of severely injured patients vulnerable to posttraumatic stress disorder (PTSD) and depression, we examined whether DHA increases serum BDNF levels and whether changes in BDNF levels are associated with subsequent symptoms of PTSD and depression. Patients received 1470 mg per day of DHA plus 147 mg per day of eicosapentaenoic acid (EPA; n=53) or placebo (n=57) for 12 weeks. Serum levels of mature BDNF and precursor pro-BDNF at baseline and 12-week follow-up were measured using enzyme-linked immunosorbent assay kits. At 12 weeks, we used the Clinician-Administered PTSD Scale to assess PTSD symptoms and depressive symptoms by the Montgomery–Åsberg Depression Rating Scale. We found a significant increase in serum BDNF levels during the trial in the DHA and placebo groups with no interaction between time and group. Changes in BDNF levels were not associated with PTSD severity but negatively associated with depression severity (Spearman''s ρ=−0.257, P=0.012). Changes in pro-BDNF were also negatively associated with depression severity (Spearman''s ρ=−0.253, P=0.013). We found no specific effects of DHA on increased serum levels of BDNF and pro-BDNF; however, evidence in this study suggests that increased BDNF and pro-BDNF have a protective effect by minimizing depression severity. 相似文献
104.
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits 总被引:1,自引:0,他引:1
Hagio T Matsumoto S Nakao S Matsuoka S Kawabata K 《Pulmonary pharmacology & therapeutics》2005,18(4):285-290
The in vivo contribution of neutrophil elastase (NE) in phorbol myristate acetate (PMA)-induced acute lung injury has so far been unclear. This study examined the role of NE in PMA-induced acute lung injury in conscious rabbits, using a specific NE inhibitor, sivelestat sodium hydrate (Sivelestat). A single bolus injection of PMA (40 microg/kg) caused acute lung injury as indicated by an increase in protein concentration and hemorrhage in bronchoalveolar lavage fluid (BALF) 4h after PMA injection. These changes were associated with mild decrease in arterial oxygen pressure and peripheral white blood cell and platelet. When continuously infused starting 1h before and ending 4h post-PMA injection, Sivelestat at 3-30 mg/kg/h that are able to inhibit rabbit NE activity by 60-90%, dose-dependently attenuated both PMA-induced hemorrhagic pneumonitis and the increase in protein concentration in BALF without affecting myeloperoxidase activity in the lung. Histopathological study indicated that sivelestat (30 mg/kg/h) markedly attenuated lung histopathological changes, alveolar hemorrhage and white blood cells migration with evidence of inhibition of NE activity in BALF. These results suggest that NE plays a significant role in PMA-induced acute lung injury and further supports the importance of this enzyme in acute lung injury. 相似文献
105.
Tamotsu Yabumoto Sohee Shin Tsuneo Watanabe Yusuke Watanabe Toru Naka Kazuo Oguri Toshio Matsuoka 《Journal of Physical Therapy Science》2015,27(9):3023-3025
[Purpose] Strength training is recommended for children with cerebral palsy. However, it
is difficult for moderately impaired children with cerebral palsy, who require crutches
for ambulation, to participate in this type of training. The purpose of this study was to
investigate whether whole-body vibration training is an effective method of strengthening
in a moderately impaired child with cerebral palsy. [Subject and Methods] This report
describes an 8-year-old Japanese boy with cerebral palsy, who was ambulatory with
crutches. The subject participated in physical therapy twice a week for 5 weeks.
Whole-body vibration training was selected to complement the standing practice. The
patient’s crutch-walking ability, gross motor function, and spasticity were evaluated.
[Results] The number of steps and walking duration were reduced in a 5-m walk test with
crutches and gross motor function was improved. Further, the spasticity was reduced.
[Conclusion] Whole-body vibration training is an effective physical therapy intervention
in moderately impaired children with cerebral palsy, who are unable to walk without
crutches.Key words: Cerebral palsy, Whole-body vibration, Walking ability 相似文献
106.
A Novel Approach to Patient Self‐Monitoring of Sonographic Examinations Using a Head‐Mounted Display 下载免费PDF全文
107.
Subacute cor pulmonale due to tumor embolism 总被引:1,自引:0,他引:1
Nakamura H Adachi H Sudoh A Yagyu H Kishi K Oh-ishi S Kusama H Hashimoto T Matsuoka T 《Internal medicine (Tokyo, Japan)》2004,43(5):420-422
We describe a patient wih subacute cor pulmonale caused by tumor emboli in the lungs. A 64-year-old female suffering from a subacute progressive cough and shortness of breathing died of severe pulmonary hypertension seven days after admission. Neither chest CT scans nor lung perfusion scintigraphy showed any abnormal findings. Microscopic examination after an autopsy revealed diffuse intravascular tumor emboli occluding not only the small pulmonary arteries and arterioles, but also the lymphatic vessels, which were suggested to be metastases of a breast carcinoma resected five years previously. Thus, pulmonary tumor embolism should be considered in the differential diagnosis of primary pulmonary hypertension, particularly in patients with a past history of cancers. 相似文献
108.
Soo Ryang Kim Fukuo Kondo Yumi Otono Susumu Imoto Kenji Ando Makoto Hirakawa Katsumi Fukuda Madoka Sasaki Soo Ki Kim Takamitsu Komaki Shinobu Tsuchida Sawako Kobayashi Toshiyuki Matsuoka Masatoshi Kudo 《Hepatology research》2014,44(5):584-590
We describe a case of serum amyloid A (SAA) and C‐reactive protein (CRP) positive nodule detected by immunohistochemical analysis in a 37‐year‐old woman with alcohol‐related cirrhosis. Imaging studies at first admission pointed to hepatocellular carcinoma (HCC), a dysplastic nodule, an inflammatory pseudotumor or focal nodular hyperplasia (FNH). Ultrasonography‐guided biopsy in Segment 2 showed minimal atypical changes, except for a slight increase in cell density and micronodular cirrhosis in the non‐nodular portion. gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid‐enhanced magnetic resonance imaging carried out after a year and a half revealed hypervascularity in the arterial phase and isointensity in the hepatobiliary phase. Three years thereafter, however, the imaging displayed a change from isointensity to a defect in the hepatobiliary phase, and the nodule demonstrated minimal histological atypia. Immunohistochemical staining of the nodule was positive for SAA, CRP, liver fatty acid‐binding protein and glutamine synthetase, but negative for β‐catenin, heat shock protein 70 and Glypican 3. Organic anion transporter (OATP)8 staining was weaker in the nodule than in the non‐nodular portion of the alcohol‐related micronodular cirrhosis. The nodule was diagnosed as an SAA and CRP positive nodule, and HCC was ruled out. Despite the change from isointensity to a defect in the hepatobiliary phase, no evidence of HCC was found in the biopsy specimen. The change may be explained more by the weak OATP8 staining compared with that of alcohol‐related liver cirrhosis than by malignant transformation into HCC. 相似文献
109.