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71.
Covalently crosslinked liquid crystalline networks with elastic properties were prepared in isotropic solution from linear liquid crystalline polymers. As linear precursors for the networks were used: (i) polymers with the mesogenic groups in the side groups (polyacrylates and polymethacrylates), (ii) polymers with the mesogenic groups in the main chain (polymalonates) and (iii) polymers with the mesogenic groups in main chain and side groups (“combined liquid crystalline polymers”). In all crosslinked polymers the liquid crystalline phases of the linear polymers are retained. For low degrees of crosslinking (≤2 mol-%) the phase transition temperatures remain nearly unchanged. These elastomers are very soft above Tg and can be easily stretched for more than 100%. For higher degrees of crosslinking the phase transition temperatures are reduced. 相似文献
72.
Tree pollens are among the most important allergen sources. Allergic cross-reactivity to pollens of trees from various plant orders has so far been classified according to botanical relationships. In this context, cross-reactivities to pollens of trees of the Fagales order (birch, alder, hazel, hornbeam, oak, chestnut), fruits and vegetables, between pollens of the Scrophulariales (olive, ash, plantain, privet, lilac) and pollens of the Coniferales (cedar, cypress, pine) are well established. The application of molecular biology methods for allergen characterization has revealed the molecular nature of many important tree pollen allergens. We review the spectrum of tree pollen allergens and propose a classification of tree pollen and related allergies based on major allergen molecules instead of botanical relationships among the allergenic sources. This molecular classification suggests the major birch pollen allergen, Bet v 1 as a marker for Fagales pollen and related plant food allergies, the major olive pollen allergen, Ole e 1, as a possible marker for Scrophulariales pollen allergy and the cedar allergens, Cry j 1 and Cry j 2, as potential markers for allergy to Coniferales pollens. We exemplify for Fagales pollen allergy and Bet v 1 that major marker allergens are diagnostic tools to determine the disease-eliciting allergen source. Information obtained by diagnostic testing with marker allergens will be important for the appropriate selection of patients for allergen-specific forms of therapy. 相似文献
73.
Fürstenau Daniel Haneke Hannah Spies Claudia Walz Tim Schewina Kai Höft Moritz Mörgeli Rudolf Balzer Felix 《Zeitschrift fur Gesundheitswissenschaften》2022,30(1):99-110
Journal of Public Health - The purpose of this paper is to investigate the implementation of value-based care principles in the context of frailty in the perioperative process, highlighting the... 相似文献
74.
75.
Quality-of-Life Outcome After Laparoscopic Adjustable Gastric Banding for Morbid Obesity 总被引:3,自引:0,他引:3
Background: The definition of success and failure of a bariatric procedure should include weight loss as well as improvement
of comorbidity and quality-of-life (QoL) assessment. QoL measures changes in physical, functional, mental, and social health
in order to evaluate benefits of new programs and interventions. Material and Methods: From April 1995 until March 1999, 287
patients underwent laparoscopic adjustable silicone gastric banding (LASGB) at Northwest Hospital Frankfurt a.M. (Germany).
In this study, 100 of 287 patients (preoperative mean BMI 48.3 kg/m2; mean age 35.2 years) with a follow-up >18 month were evaluated. All patients underwent anonymous questionnaire (26 questions
with a maximum score of 60) about different aspects of QoL outcome after LSAGB. Results: In this study, 4 of 100 patients
refused to give an answer to the QoL questions. Therefore 96 patients were evaluated. The QoL auto-evaluation of the patients
shows that QoL generally improved after surgery in 92%. Using the scoring system, 44% of patients have excellent, 52% good,
and only 4% bad results. The 4 patients who refused had to be classified as failure. General acceptance of LSAGB is wide,
but gastrointestinal side effects are recognizable in more than 78% of operated patients. Successful weight loss is followed
by an improvement of comorbidities. Conclusions: Safe, effective bariatric procedures increase the quality of life in morbidly
obese patients markedly. Bariatric surgeons are committed to support and help their patients until they reach a new quality
of life after obesity surgery. 相似文献
76.
This study investigated Subjective Quality of Life (SQOL) in 42 women with depression, 70 women with alcoholism, and 73 women with schizophrenia within 3 weeks after hospital admission. Twenty-eight of the depressive patients were re-examined after 6 months. SQOL was assessed using the German version of the Lancashire Quality of Life Profile. On average, depressive women expressed dissatisfaction with life as a whole and with 4 out of 8 life domains, and had a lower SQOL than the other two diagnostic groups. Differences remain statistically significant when the influence of age and anxiety/depression is controlled for. SQOL in depressive women improved significantly within the follow up period. Positive SQOL change was moderately correlated with an improvement of depressive symptoms. The results indicate that depressive women after hospital admission express an unusually low SQOL, which seems to have some diagnostic specificity and improves over time. Changes in depressive symptoms do not fully explain SQOL changes. 相似文献
77.
Penetration of ciprofloxacin, norfloxacin and ofloxacin into the aqueous humor using different topical application modes 总被引:3,自引:0,他引:3
R. Beck Jan van Keyserlingk Ulrike Fischer Rudolf Guthoff Bernd Drewelow 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1999,237(2):89-92
· Background: A prospective study was undertaken to determine the transcorneal penetration of three topically applied fluoroquinolones
into aqueous humor. · Methods: Cataract patients (n=224) preoperatively received topically applied gyrase inhibitors (0.3% ciprofloxacin, 0.3% norfloxacin, 0.3% ofloxacin) in
two different application modes. In application mode I, patients received on the day before operation 3×1 eye drop at 2-h
intervals, and on the day of operation 3 drops at 1-h intervals. In application mode II, patients received 9 drops at 15-min
intervals on the day of operation only. Just before cataract surgery 50–100 μl aqueous humor was aspirated and stored at –80
°C. The HPLC method was used for measuring the concentration. · Results: The highest concentrations of all tested antibiotics
were measured after the mode of application in which one drop was given every 15 min between 06:00 and 08:00 hours before
operation. In this mode, ciprofloxacin achieved a mean aqueous level of 379.8±327.8 μg/l (range 33–1388 μg/l), norfloxacin
182.1±118.1 μg/l (range 38–480 μg/l) and ofloxacin 563.9±372.1 μg/l (range 64–1455 μg/l). These mean concentration are all
above the MIC90 of gram-negative bacteria like Proteus mirabilis and Escherichia coli. In some cases the concentrations of ciprofloxacin and ofloxacin, but never norfloxacin, reached therapeutic values above
the MIC90 of Staphylococcus aureus and Staphylococcus epidermidis · Conclusions: The mean concentration value of 0.3% ciprofloxacin and of 0.3% ofloxacin in the aqueous humor reached the MIC90 values of the frequently occurring gram-positive and gram-negative bacteria. Of the currently available topical fluoroquinolones,
ofloxacin achieved the highest aqueous humor concentration. Considering the higher antimicrobial activity of ciprofloxacin,
both ciprofloxacin and ofloxacin may be useful ophthalmic agents in antibacterial management, but they are not efficient against
Streptococcus pneumoniae and Pseudomonas aeruginosa.
Received: 8 September 1997 Revised version received: 19 March 1998 Accepted: 8 April 1998 相似文献
78.
79.
Detection of drug-induced apoptosis by flow cytometry after alkaline extraction of ethanol fixed cells 总被引:5,自引:0,他引:5
Mihalik R Uher F Pocsik É Berczi L Benczur M Kopper L 《Pathology oncology research : POR》1996,2(1-2):78-83
A new flow cytometric method was developed to detect apoptotic cells with fragmented DNA and to determine cell cycle distribution
of viable cells, in the same sample, by propidium iodide staining. Apoptosis, in HT58 human B lymphoma cells, was induced
by etoposide and/or by staurosporine. Using appropriate alkaline solutions (between 1-10 mN NaOH in 150 mM saline) followed
by neutralization with buffer solution, the fragmented DNA can be extracted quantitatively from ethanol fixed cells. Further,
good resolution of the cell cycle distribution can be obtained in unimpaired cells without RNase treatment. Furthermore, unlike
the widely used hypotonic-detergent extraction of unfixed cells, the suggested extraction method can prevent drug-induced
disintegration of dead cells when karyorrhexis occurs.
This work was supported by Hungarian National Research Foundation (OTKA I/352 and OTKA II/2622). 相似文献
80.
Michael Stöckle Stefan Wellek Walter Meyenburg Gunther E. Voges Ulla Fischer Ulrich Gertenbach joachim W. Thüroff Christoph Huber Rudolf Hohenfellner 《Urology》1996,48(6):868-875