Taxonometry, ecology and evolutional relation of rickettsia

Ecology of Rickettsia is main direction of researches of RAMS academician I. V. Tarasevich and her team. Characteristics of alpha 1-Protobacteriae--parasites of eukaryotic cells--given in the work. The accent to Rickettsia characteristics in relation of their evolution relationship with eukaryote mitochondria is made. Main directions of researches in Q-fever, Tsutsugamushi fever, rickettsioses of tick-borne spotted fever (TSF) group, performed in our country under direction of RAMS academician I. V. Tarasevich, are represented. Results of study with the use of tick experimental model, monoclonal antibodies and genetical methods of TSF group Rickettsia, revealed in Siberia and Far East (focal territories of tick-born rickettsioses) and also in territories with the absence of this infection in Russia and Kazakhstan, are given.     

Endovascular balloon valvuloplasty of pulmonary artery valvular stenosis

Summarized experience of balloon valvuloplasty in isolated stenosis of pulmonary artery valve is analyzed. This procedure was performed in Russian Research Center of Surgery in 53 patients from 1980 to 2006. The technique of balloon valvuloplasty is described; short- and long-term results are analyzed. Complications and unsatisfactory results of this surgery are outlined.     

The effect of collagen-normalizing therapy on the incidence and severity of anesthetic and postoperative complications in children with connective tissue syndromes

A new method of collagen-normalizing therapy has been worked out to prevent specific anesthesia-induced, operative and postoperative complications and to treat some symptoms in children with Ehlers-Danlos and Marfan's syndromes and with non-classified Marfan-like malformations. The technique involves a combined use of beta-adrenoblocker in the age-matched doses and vitamins C/0.03 g/(kg.day)/, B2/0.0004 g/(kg.day)/and B6/0.002 g/(kg.day)/ for 2.5 months before surgery and during the first 2 weeks of the postoperative period. The above therapy reduces the incidence of delayed recovery of the muscular tone and adequate respiration, spontaneous and recurrent pneumothorax, hemorrhagic and gastroenterologic complications, as well as the incidence and severity of intestinal paresis. The indexes of effective collagen-normalizing therapy are as follows: body weight increase, echocardiographic pattern of reduced diameter of the aorta and mitral valve prolapse, normalization of the urinary excretion of total and polypeptide-bound oxyproline. The efficacy of therapy depends on the baseline level of oxyproline excretion.