全文获取类型
收费全文 | 2735篇 |
免费 | 138篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 222篇 |
妇产科学 | 138篇 |
基础医学 | 301篇 |
口腔科学 | 48篇 |
临床医学 | 166篇 |
内科学 | 451篇 |
皮肤病学 | 199篇 |
神经病学 | 90篇 |
特种医学 | 51篇 |
外国民族医学 | 1篇 |
外科学 | 637篇 |
综合类 | 38篇 |
一般理论 | 2篇 |
预防医学 | 127篇 |
眼科学 | 70篇 |
药学 | 165篇 |
中国医学 | 3篇 |
肿瘤学 | 166篇 |
出版年
2023年 | 13篇 |
2022年 | 32篇 |
2021年 | 102篇 |
2020年 | 48篇 |
2019年 | 76篇 |
2018年 | 71篇 |
2017年 | 69篇 |
2016年 | 86篇 |
2015年 | 84篇 |
2014年 | 95篇 |
2013年 | 140篇 |
2012年 | 195篇 |
2011年 | 190篇 |
2010年 | 139篇 |
2009年 | 98篇 |
2008年 | 156篇 |
2007年 | 207篇 |
2006年 | 124篇 |
2005年 | 130篇 |
2004年 | 126篇 |
2003年 | 99篇 |
2002年 | 81篇 |
2001年 | 53篇 |
2000年 | 47篇 |
1999年 | 48篇 |
1998年 | 29篇 |
1997年 | 21篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 20篇 |
1991年 | 17篇 |
1990年 | 19篇 |
1989年 | 28篇 |
1988年 | 34篇 |
1987年 | 13篇 |
1986年 | 15篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 14篇 |
1981年 | 9篇 |
1979年 | 11篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1972年 | 7篇 |
1971年 | 17篇 |
1969年 | 7篇 |
1968年 | 9篇 |
排序方式: 共有2883条查询结果,搜索用时 15 毫秒
991.
S. S. Timoshin I. G. Yakovenko G. P. Berezina G. G. Obukhova A. Yu. Rubina N. B. Murzina 《Bulletin of experimental biology and medicine》1997,124(4):965-967
The effect of hydra peptide morphogen on poststress disturbances in albino rats is evaluated. A 4-h immobilization leads to
a rise of corticosterone, activates lipid peroxidation, impairs antioxidant defense system, and induces a marked decrease
in the content of thyrotropic hormone and thyroxine. The relative weight of the thymus significantly decreases 24 h after
immobilization. Moreover, stress inhibits proliferative processes in corneal and pyloric epithelium immediately and 24 h after
immobilization. Hydra peptide morphogen prevents the endocrine shift, normalizes the content of lipoperoxides and α-tocopherol
immediately after stress, weakens poststress proliferation disturbances, induces compensatory stimulation of proliferative
processes in the corneal epithelium 24 h after stress, and normalizes DNA synthesis in the pyloric epithelium, the level of
malonic dialdehyde being elevated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 392–395, October, 1997 相似文献
992.
The minimum effective doses of pethidine and doxapram in the treatment of post-anaesthetic shivering 总被引:9,自引:0,他引:9
This study was designed to find the minimum effective doses of doxapram and pethidine to stop post-anaesthetic shivering. Two hundred and twenty healthy patients who shivered following routine surgery were allocated randomly to receive one of 10 doses of doxapram (0.18, 0.23, 0.29, 0.35, 0.41, 0.47, 0.7, 0.93, 1.17 and 1.4 mg.kg−1 ), one of five doses of pethidine (0.12, 0.18, 0.23, 0.29 and 0.35 mg.kg−1 ) or saline. Probit analysis demonstrated that the number of patients who stopped shivering with doxapram was independent of the amount of drug given in this dose range. The lowest dose of doxapram (0.18 mg.kg−1 ) was significantly more effective than placebo (p < 0.01). For pethidine there was a dose-dependent effect on shivering to a maximum of 95% of patients successfully treated with 0.35 mg.kg−1 . We conclude that 0.35 mg.kg−1 of pethidine is the minimum dose required to treat post-anaesthetic shivering effectively. We also conclude that 0.18 mg.kg−1 of doxapram is as effective as 1.4 mg.kg−1 in the treatment of post-anaesthetic shivering. Further study is required to find the minimum effective dose of doxapram. 相似文献
993.
N Bhattacharya S Mahajan K N Sharma 《Indian journal of physiology and pharmacology》1991,35(2):125-129
Effect of i.v. morphine (1-2 mg/kg) on blood pressure changes evoked by sciatic nerve stimulation (SNS) were studied in chloralose anaesthetised cats. SNS gave a depressor, pressor or a biphasic BP response generally linked to the parameters of stimulation. Morphine produced marked attenuation of depressor and some facilitation of pressor response, suggesting a possible reciprocal relationship between depressor and pressor responses. Depressor response has been correlated with deep tissue or visceral pain mediated through A delta fibres and pressor response to cutaneous nociception involving C fibres or non nociceptive input via group II fibres. Involvement of medullary regions in differential modulation of these depressor and pressor response has been suggested. 相似文献
994.
Mahavir Singh Griwan Bhawani Shanker Sharma Rajesh Kumar Mahajan Vijay Kumar Kak 《Child's nervous system》1993,9(8):462-465
Seventy children with posterior fossa tumours treated over a period of 6 1/2 years were studied. Most patients presented in the late stage of disease. Sixty-four required insertion of a precraniotomy shunt for one or more of the following: persistent vomiting, severe headache, dehydration, poor general condition, failing vision, altered sensorium, marked periventricular lucency, and brain stem involvement deferring total removal of the tumour. Insertion of precraniotomy shunt improved the general condition and signs and symptoms of increased intracranial pressure. It also provided a lax brain during definitive surgery and a smooth postoperative course. Shunt-related complications, consisting of block and/or infection, were observed in 21 patients. It was concluded that precraniotomy shunt is important in the management of children with posterior fossa tumours in developing countries where these patients present in the late stage of disease. 相似文献
995.
996.
V M Mahajan 《The British journal of ophthalmology》1983,67(3):191-194
The aerobic microbial flora of 823 eyes with acute bacterial conjunctivitis, corneal ulceration, dacryocystitis, discharging sockets, blepharitis, and postoperative infections has been investigated. Staphylococci, Streptococcus pneumoniae, and nonfermenting Gram-negative bacilli including Pseudomonas aeruginosa were the main pathogens. Fermenting coliforms were also infrequently isolated. The least overall resistance of 30.9% was to chloramphenicol, but no one antibiotic was effective against all pathogens. Cloxacillin is the best drug for staphylococcal and polymyxin B for pseudomonas infections. 相似文献
997.
P Menon K L N Rao A Bhattacharya B R Thapa S K Chowdhary J K Mahajan R Samujh 《Zeitschrift für Kinderchirurgie》2005,15(2):82-87
AIM: This study was carried out in order to determine whether children with extrahepatic portal hypertension show any improvement in growth parameters and quality of life after elective surgery. PATIENTS AND METHODS: All patients with extrahepatic portal hypertension who underwent surgery between April 1999 and March 2002 were studied prospectively. Height and weight before and after surgery were converted into Z scores for comparison. The quality of life was assessed by changes in scholastic ability, physical activity, social interaction, and economic effects on the family. RESULTS: At the end of a minimum follow-up period of 1 year, of the 30 children, 50 % and 76 % showed improvement in weight and height Z scores, respectively, compared to their scores while on medical management. Z scores below - 2 SD for weight and height were seen in 57 % and 37 % of patients prior to surgery, and only in 40 % and 20 %, respectively at the end of follow-up, which ranged from 1 - 4 years. The improvement in height and weight was more in those who had undergone splenectomy with either devascularization or central splenorenal shunt compared to those who had undergone side-to-side lienorenal shunt without splenectomy. The children, who had dropped out of school while on medical management, either rejoined school or attended vocational courses after surgery. There was an improvement in school performance and physical activity in 85 % of the children. Improvement in personality was seen in 73 % of the affected patients. The cost incurred for surgery was one-third of the amount spent while on medical management. CONCLUSIONS: Growth parameters improved significantly in children after surgical intervention for portal hypertension. Overall improvement in scholastic abilities, physical activity, and social interaction was noted in a majority of the patients. As a one-time procedure in a developing country, surgery is also more cost effective. 相似文献
998.
999.
K L Narasimhan B Kaur S K Chowdhary A Bhalla R Samujh K L N Rao J K Mahajan 《Zeitschrift für Kinderchirurgie》2002,12(4):267-271
AIM: The present prospective study focuses on the effect of transurethral fulguration (TUF) and vesicostomy on the renal functions and somatic growth in posterior urethral valves (PUV). PATIENTS AND METHODS: 37 consecutive neonates were diagnosed and treated for PUV with vesicostomy (18 patients) and TUF (19 patients). Postoperative stable creatinine values, renal function and somatic growth were recorded. Standard anthropometric techniques and standard statistical methods were used to compute distance statistics for body weight and crown-heel length at age intervals of 3 months for the first year. OBSERVATIONS: The distance values of body weight and crown-heel length of these groups of children were less than the 5th percentile of the National Centre For Health Statistics (NCHS) and healthy Punjabi infants showing growth retardation in the first year of life. Pre- and postoperative mean serum creatinine of the fulguration group was 1.5 +/- 1.5 mg/dl and 0.8 +/- 0.3 mg/dl and for vesicostomy it was 2.4 +/- 2.2 mg/dl, and 0.9 +/- 0.7 mg/dl respectively. The babies of the fulguration group showed better growth attainments than the babies of the vesicostomy group at the end of one year. CONCLUSION: At the end of one year, babies of the fulguration group had a similar growth velocity compared to the vesicostomy group, though in general they showed retarded growth compared to healthy counterparts. The modality of treatment chosen did not seem to affect the renal functions or somatic growth in the short-term follow-up. 相似文献
1000.
A medium term analysis of the subjective efficacy of treatment for women with detrusor instability and low bladder compliance 总被引:6,自引:0,他引:6
C. J. Kelleher Senior Registrar L. D. Cardozo Professor V. Khullar Registrar S. Salvatore Registrar 《BJOG : an international journal of obstetrics and gynaecology》1997,104(9):988-993
Objective The aims of this study were to determine the medium term subjective outcome of treatment for women with a urodynamic diagnosis of detrusor instability and low bladder compliance.
Setting A tertiary referral Urogynaecology clinic.
Participants and methods One thousand one hundred and five women referred for the investigation of their urinary symptoms were entered into a prospective, long term, quality of life study. Of these, 348 had a videourodynamic diagnosis of detrusor instability or low bladder compliance and form the basis of this paper. Women were contacted by post at least six months following their urodynamic assessment and asked to complete a questionnaire detailing their treatment, its efficacy and side effects, and any residual urinary symptoms.
Results Two hundred and fifty-six women (73.6%) responded to follow up; only 5.5% were cured of their urinary symptoms. The majority (90.2%) had received anticholinergic medication, although only 18.2% continued with this treatment in excess of six months. Many women had residual urinary symptoms following their investigation and treatment.
Conclusion The medium term efficacy of the treatment of detrusor instability and low compliance is disappointing, and a large part of this failure may be attributable to poor treatment efficacy, side effects of medication, or inadequate follow up following the diagnosis and instigation of therapy. 相似文献
Setting A tertiary referral Urogynaecology clinic.
Participants and methods One thousand one hundred and five women referred for the investigation of their urinary symptoms were entered into a prospective, long term, quality of life study. Of these, 348 had a videourodynamic diagnosis of detrusor instability or low bladder compliance and form the basis of this paper. Women were contacted by post at least six months following their urodynamic assessment and asked to complete a questionnaire detailing their treatment, its efficacy and side effects, and any residual urinary symptoms.
Results Two hundred and fifty-six women (73.6%) responded to follow up; only 5.5% were cured of their urinary symptoms. The majority (90.2%) had received anticholinergic medication, although only 18.2% continued with this treatment in excess of six months. Many women had residual urinary symptoms following their investigation and treatment.
Conclusion The medium term efficacy of the treatment of detrusor instability and low compliance is disappointing, and a large part of this failure may be attributable to poor treatment efficacy, side effects of medication, or inadequate follow up following the diagnosis and instigation of therapy. 相似文献