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141.
摘 要 目的: 建立顶空进样气相色谱法检测比卡鲁胺原料药中7种有机残留溶剂二氯甲烷、正己烷、四氢呋喃、乙醇、乙醚、丙酮和乙酸乙酯的方法。方法: 色谱柱为Agilent DB 624弹性石英毛细管柱(30.0 m×0.25 mm×1.4 μm);进样口温度:200℃;氢火焰离子化检测器(FID)温度:250℃;柱温:程序升温,初始温度35℃,保持13 min,再以100℃/min的速率升至180℃,维持5 min;载气:氮气;流速:1.2 ml·min-1。顶空进样,顶空平衡温度:90℃,顶空平衡时间:30 min;进样体积:1.0 ml;以二甲基亚砜为溶解介质,测定比卡鲁胺中7种溶剂的残留量。结果: 各被测溶剂均能良好分离,各溶剂峰面积与浓度均呈良好的线性关系,回收率均较为理想。 结论:该法适用于比卡鲁胺原料药中残留溶剂的测定。 相似文献
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Yucheng Wang Shihong Ren Xiaokang Gong Jiacheng Wang Ning Zhu Danyang Cai Jianwei Ruan 《Medicine》2021,100(4)
Melanoma can spread to the bone by metastasis and is relevant to a poor outcome. However, because of the rarity of melanoma patients with bone metastasis, the prognostic postoperative survival factors of them have not been elucidated. The aim of this special population-based cohort was to elucidate the prognostic factors associated with postoperative survival. The Surveillance, Epidemiology, and End Results database was used to extract postoperative survival data relating to patients with melanoma and bone metastasis at diagnosis between 2010 and 2016, along with data on a range of potential postoperative prognostic factors. We then investigated the potential postoperative prognostic roles of these factors using a Cox regression model and the Kaplan-Meier analysis. In all, the Surveillance, Epidemiology, and End Results database included 186 cases. Regarding overall survival, the 1-, 3-, and 5-year overall survival rates for the entire cohort were 36.2%, 15.4%, and 9.5%, respectively. Regarding cancer-specific survival, the 1-, 3-, and 5-year cancer-specific survival rates were 42.0%, 23.2%, and 16.6%, respectively. Within a cohort of melanoma patients with bone metastasis after surgery, our analysis showed that a smaller tumor size and the lack of metastases at other sites were predictors of survival. 相似文献
145.
Amgalan Anar Maher Alexander S. Ghosh Satyaki Chui Helena C. Bogdan Paul Irimia Andrei 《Age (Dordrecht, Netherlands)》2022,44(5):2509-2525
GeroScience - Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging... 相似文献
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目的:探讨远志对锰中毒小鼠学习记忆和海马CaMKII表达的影响。方法:将60只雌性昆明小鼠随机分为对照组(CG),锰中毒组(MG),锰中毒加远志低剂量组(MLG),锰中毒加远志中剂量组(MMG),锰中毒加远志高剂量组(MHG)。氯化锰(15 mg/kg)采用腹腔注射方式,远志干预(2.5,5,10 g/kg)采用灌胃给药。实验后,动物用Morris水迷宫检测其空间学习和记忆成绩。用免疫组织化学的方法检测海马齿状回区(DG)Ca MKII的表达。结果:在水迷宫的定位航行实验中,各组小鼠的逃避潜伏期与锰中毒组相比,对照组平均逃避潜伏期明显降低(P0.01),远志干预低、中、高剂量组平均逃避潜伏期明显降低(P0.01);在空间探索实验中,与锰中毒组相比,对照组穿越平台次数明显增高(P0.01),远志干预低、中、高剂量组穿越平台次数明显增加(P0.01)。免疫组织化学分析,与对照组相比,锰中毒组DG区Ca MKII表达明显下降,(P0.01),而远志干预低、中、高剂量组海马内CaMKII表达比锰中毒组明显增高(P0.01)。结论:锰中毒小鼠海马齿状回Ca MKII的表达下降,药物远志能够改善锰中毒小鼠学习记忆能力的机制可能与CaMKII的表达增加有关。 相似文献
148.
Mutant Ts/+ fetuses are developmentally retarded as compared to normal +/+ littermates. Mutant fetuses have less total hemoglobin than do normal fetuses of the same gestational age. However, when compared to +/+ fetuses of similar body weight, Ts/+ fetuses have the appropriate amount of total hemoglobin, suggesting that the apparent anemia observed in mutant fetuses is most likely the result of delay in growth and development. Changes in proportions of embryonic hemoglobins during fetal development are similar in Ts/+ and +/+ fetuses at day 12 and later of gestation. Moreover, adult hemoglobin is detected in circulating primitive nucleated erythrocytes in the developmentally retarded Ts/+ mutant fetuses at about the same chronologic age as their +/+ normal littermates. 相似文献
149.
China’s HIV epidemic may be shifting towards predominantly sexual transmission and emerging data point to potential increases
in HIV prevalence among men who have sex with men (MSM). There is particular need to assess the extent of risk behavior among
MSM outside of China’s most cosmopolitan cities. We conducted a respondent-driven sampling survey (N = 428) to measure HIV seroprevalence and risk behavior among MSM in Jinan, China, the provincial capital of Shandong. HIV
prevalence was 0.5% (95% confidence interval [CI] 0.1–1.0). Unprotected anal intercourse (UAI) in the last 6 months (reported
by 61.4%) was associated with buying or selling sex to a man in the last 6 months, syphilis infection, multiple partners in
the last month, low HIV knowledge and migrant status. No participant had previously tested for HIV. Risk for HIV transmission
is widespread among MSM throughout China; basic prevention programs are urgently needed. 相似文献
150.
In this work, tobacco stem active carbon (TSAC) catalysts loaded on to CuO and Fe2O3 were prepared by a sol–gel method and used for the simultaneous removal of hydrogen sulfide (H2S), carbonyl sulfide (COS) and carbon disulfide (CS2). The influences of the operating conditions such as reaction temperature, relative humidity (RH), O2 concentration, and gas hourly space velocity (GHSV) were discussed. DRIFTS results showed that the deactivation was attributed to the generation of S and sulfates. H2O promoted the generation of sulfate. The enhancement of the hydrolysis of COS/CS2 was due to the promotion of H2S oxidation by O2. A high GHSV decreased the contact time between the gases and the catalyst. Meanwhile, a high GHSV was not conducive to the adsorption of gases on the surface of the catalyst. XPS results indicated that the deactivation of the catalyst was attributable to the formation of S containing components, such as thiol/thioether, S, –SO– and sulfate. BET results indicated that the adsorptive ability of the catalyst was related to the microporous volume and surface area.The removal processes of COS, CS2 and H2S could be divided into two parts: a catalytic hydrolysis reaction and a catalytic oxidation reaction. 相似文献