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81.
Mannucci E Tesi F Bardini G Ognibene A Petracca MG Ciani S Pezzatini A Brogi M Dicembrini I Cremasco F Messeri G Rotella CM 《Diabetes, nutrition & metabolism》2004,17(6):336-342
Metformin has been shown to increase glucagon-like peptide-1 (GLP-1) levels after an oral glucose load in obese non-diabetic subjects. In order to verify if this effect of the drug was also present in obese Type 2 diabetic patients who have never been treated with hypoglycemic drugs, 22 Type 2 diabetic and 12 matched non-diabetic obese patients were studied. GLP-1 was measured before and after a 100 g glucose load at baseline, after a single oral dose of 850 mg of metformin, and after 4 weeks of treatment with metformin 850 mg three times daily. Post-load GLP-1 levels were significantly lower in diabetic patients. A single dose of metformin did not modify GLP-1 levels. After 4 weeks of treatment, fasting GLP-1 increased in diabetic patients (3.8 vs 4.9 pmol/l; p<0.05), while the incremental area under the curve of GLP-1 significantly increased in both diabetic [93.6 (45.6-163.2) vs 151.2 (36.0-300.5) pmol x min/l; p<0.05] and non-diabetic [187.2 (149.4-571.8) vs 324.0 (238.2-744.0) pmol x min/l; p<0.05] subjects. In conclusion, GLP-1 levels after an oral glucose load in obese type 2 diabetic patients were increased by 4 weeks of metformin treatment in a similar fashion as in obese subjects with normal glucose tolerance. 相似文献
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Ricca V Mannucci E Mezzani B Moretti S Di Bernardo M Bertelli M Rotella CM Faravelli C 《Psychotherapy and psychosomatics》2001,70(6):298-306
BACKGROUND: : The treatment of binge eating disorder (BED) is still the object of debate. In the present study, the effectiveness of antidepressant drugs (fluoxetine - FLX - 60 mg/day, fluvoxamine - FLV -300 mg/day), cognitive-behavioural therapy (CBT) and combined treatments (CBT + FLX, CBT + FLV) has been evaluated in a randomized, clinical trial. Results at the end of the active treatment (in the 24th week) and 1-year follow-up outcomes have been evaluated. METHODS: One hundred eight (44 M, 64 F) BED patients were randomly assigned to either CBT, FLX (60 mg/day), FLV (300 mg/day), CBT + FLX or CBT + FLV, for 24 weeks. At the beginning (T0), at the end (T1) of treatment and after 1 year (T2), body mass index (BMI) and eating attitude and behaviours (by EDE 12.0D) were assessed. RESULTS: At T1, BMI and EDE scores were significantly reduced in CBT, CBT + FLX and CBT + FLV, but not in the FLX and FLV treatment groups. In the CBT + FLV group, a greater (p < 0.05) reduction of EDE total scores was observed, when compared to CBT + FLX or CBT treatment groups. At T2, BMI was significantly higher than at T1, but still significantly lower than at T0 in the CBT, CBT + FLX and CBT + FLV groups, while EDE scores remained unchanged from T1 in all treatment groups. CONCLUSIONS: CBT was more effective than FLX or FLV in the treatment of BED. The addition of FLX to CBT does not seem to provide any clear advantage, while the addition of FLV could enhance the effects of CBT on eating behaviours. Modifications of eating behaviours are maintained at the 1-year follow-up, although the lost weight was partly regained. 相似文献
88.
Cole K. J. Rotella Diane L. Harper John G. 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,121(3):263-269
This experiment addressed the often-posed theory that age-related declines in manual dexterity result from diminished tactile
function. We measured the time ’young’ subjects (n=33; mean=45 years) and ’old’ subjects (n=33; mean=74 years) needed to grip (thumb and index finger), lift, and transport a small metal sphere when vision was permitted
and when blindfolded. Subjects began each trial by reaching for the sphere and were instructed to complete the entire task
quickly. In the absence of visual information, placement of the finger and thumb for a secure grip and lift cannot be performed
efficiently without tactile information. If age-related tactile changes are functionally significant for this task, then without
visual information the ’old’ group should show a disproportionate increase in the duration of the grip and lift phase of the
task compared to the ’young’ group. Perceptual thresholds for tactile pressure stimuli (Semmes-Weinstein filaments) confirmed
well-known age-related changes. Age and vision effects were manifest mainly during the grip-lift phase (time from object contact
to lift-off from its support surface), with the expected finding that the ’old’ group required more time than ’young’ group,
regardless of visual condition. The main finding was that the ’grip-lift’ duration in the ’no-vision’ condition was about twice the duration observed in the ’vision’
condition for both age groups (ratios of 2.1 and 2.3 for ’young’ and ’old’, respectively). This similar relative slowing for
the two groups fails to support the hypothesis that old adults’ ability to grip and lift the object was limited by changes
in the availability or use of tactile information.
Received: 30 September 1997 / Accepted: 26 January 1998 相似文献
89.
Edoardo Mannucci Valdo Ricca Carlo M. Rotella 《The International journal of eating disorders》1997,21(1):99-102
Eating disorders in patients with type I diabetes show some peculiar clinical features. We report the case of a young type I diabetic woman with binge eating disorder and dysthymic disorder. The patient shows a poor metabolic control and her body mass index is within the normal range. The eating disorder has been present for 3 years, and it developed after recurrent nocturnal hypoglycemic episodes. The authors discuss the complex relationships between binge eating disorder and hypoglycemic reactions and underline the diagnostic problems typical of comorbidity between type I diabetes and binge eating disorder. © 1997 by John Wiley & Sons, Inc. 相似文献
90.
The adenylate cyclase system was studied in hyperfunctioning autonomous nodules in comparison with normal thyroid tissue. The basal, TSH- and NaF-stimulated adenylate cyclase activities were tested in purified plasma membrane preparations. Basal enzyme activity in membranes from hyperfunctioning nodules was variable and the response to TSH was either normal, low or absent. The present study demonstrates that an intact adenylate cyclase activity, hyporesponsive to TSH, may exist in the cell membrane of the adenoma. 相似文献