全文获取类型
收费全文 | 59821篇 |
免费 | 5662篇 |
国内免费 | 4239篇 |
专业分类
耳鼻咽喉 | 615篇 |
儿科学 | 550篇 |
妇产科学 | 577篇 |
基础医学 | 6873篇 |
口腔科学 | 1199篇 |
临床医学 | 7844篇 |
内科学 | 8587篇 |
皮肤病学 | 674篇 |
神经病学 | 2631篇 |
特种医学 | 1929篇 |
外国民族医学 | 41篇 |
外科学 | 6022篇 |
综合类 | 10733篇 |
现状与发展 | 19篇 |
一般理论 | 14篇 |
预防医学 | 4560篇 |
眼科学 | 1672篇 |
药学 | 6402篇 |
67篇 | |
中国医学 | 3495篇 |
肿瘤学 | 5218篇 |
出版年
2024年 | 234篇 |
2023年 | 935篇 |
2022年 | 2368篇 |
2021年 | 3175篇 |
2020年 | 2354篇 |
2019年 | 1932篇 |
2018年 | 2076篇 |
2017年 | 1838篇 |
2016年 | 1699篇 |
2015年 | 2842篇 |
2014年 | 3408篇 |
2013年 | 2965篇 |
2012年 | 4290篇 |
2011年 | 4755篇 |
2010年 | 3294篇 |
2009年 | 2671篇 |
2008年 | 3189篇 |
2007年 | 3186篇 |
2006年 | 3173篇 |
2005年 | 3058篇 |
2004年 | 2257篇 |
2003年 | 2097篇 |
2002年 | 1710篇 |
2001年 | 1454篇 |
2000年 | 1348篇 |
1999年 | 1369篇 |
1998年 | 920篇 |
1997年 | 865篇 |
1996年 | 637篇 |
1995年 | 668篇 |
1994年 | 557篇 |
1993年 | 327篇 |
1992年 | 369篇 |
1991年 | 334篇 |
1990年 | 289篇 |
1989年 | 248篇 |
1988年 | 203篇 |
1987年 | 198篇 |
1986年 | 133篇 |
1985年 | 114篇 |
1984年 | 65篇 |
1983年 | 37篇 |
1982年 | 22篇 |
1981年 | 27篇 |
1980年 | 8篇 |
1979年 | 22篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
The association of XRCC1 haplotypes and chromosomal damage levels in peripheral blood lymphocyte among coke-oven workers. 总被引:1,自引:0,他引:1
Shuguang Leng Juan Cheng Linyuan Zhang Yong Niu Yufei Dai Zufei Pan Bin Li Fengsheng He Yuxin Zheng 《Cancer epidemiology, biomarkers & prevention》2005,14(5):1295-1301
Theoretically, a haplotype has a higher level of heterozygosity than individual single nucleotide polymorphism (SNP) and the association study based on the haplotype may have an increased power for detecting disease associations compared with SNP-based analysis. In this study, we investigated the effects of four haplotype-tagging SNPs (htSNP) and the inferred haplotype pairs of the X-ray cross-complementing group 1 (XRCC1) gene on chromosome damage detected by the cytokinesis-block micronucleus assay. The study included 141 coke-oven workers with exposure to a high level of polycyclic aromatic hydrocarbons and 66 nonexposed controls. The frequencies of total MN and MNed cells were borderline associated with the Arg(194)Trp polymorphism (P = 0.053 and P = 0.050, respectively) but not associated with the Arg(280)His, Arg(399)Gln and Gln(632)Gln polymorphisms among coke-oven workers. Five haplotypes, including CGGG, TGGG, CAGG, CGAG, and CGGA, were inferred based on the four htSNPs of XRCC1 gene. The haplotype CGGG was associated with the decreased frequencies of total MN and MNed cells, and the haplotypes TGGG and CGAG were associated with the increased frequencies of total MN and MNed cells with adjustment for covariates among coke-oven workers. This study showed that the haplotypes derived from htSNPs in the XRCC1 gene were more likely than single SNPs to correlate with the polycyclic aromatic hydrocarbon-induced chromosome damage among coke-oven workers. 相似文献
992.
16例直肠腺瘤的CT影像分析 总被引:1,自引:0,他引:1
[目的]探讨直肠腺瘤的CT表现.[方法]对16例经病理证实的直肠腺瘤CT表现进行回顾性分析.[结果]16例腺瘤按病理类型分为绒毛状腺瘤,管状绒毛状腺瘤和管状腺瘤,其中8例恶变.CT征象如下:广基生长有8例,窄基带蒂生长的5例,环壁增厚的有4例;向腔内匍匐式或菜花状生长的有10例;占肠周径比率在1/3以下的9例;病灶与直肠壁相贴时留下通气的间隙7例,可作为直肠腺瘤的特征性表现.[结论]一般直肠腺瘤均具有典型的CT表现,术前明确的腺瘤的CT诊断对于手术方式有重要影响. 相似文献
993.
GM-CSF基因重组腺病毒载体的构建及鉴定 总被引:2,自引:0,他引:2
目的:构建人粒细胞-巨噬细胞集落刺激因子(GM-CSF)基因的重组腺病毒载体,为进一步研究GM-CSF基因在肿瘤基因治疗中的应用提供实验基础。方法:采用PCR方法,从重组质粒pcDNA3.1-GM-CSF扩增出GM-CSF基因片段,通过穿梭质粒pShuttle,将带有CMV启动子的目的片段克隆入Adeno-X腺病毒DNA中,获得重组腺病毒DNA,通过脂质体转染HEK293细胞,经包装扩增后,获得重组腺病毒Adeno-X-GM-CSF,PCR鉴定,ELISA法检测表达产物。结果:含GM-CSF基因的重组腺病毒Adeno-X-GM-CSF构建成功,经PCR鉴定和DNA测序等证实了其正确性,重组腺病毒上清液中GM-CSF表达量达26ng/mL。结论:含GM-CSF基因的重组腺病毒构建成功。 相似文献
994.
章剑剑 《国外医学(肿瘤学分册)》2005,32(10):736-739
白细胞介素-13(IL-13)是一类由P600 cDNA编码的细胞因子,与哮喘病和肾病的关系甚为紧密.但近年来国外学者发现与肿瘤尤其是恶性肿瘤也有着密切的关系,如IL-13在恶性肿瘤的发生发展过程中起重要作用,其受体在许多恶性肿瘤如肾细胞癌、Kaposi肉瘤、多形性胶质母细胞瘤等细胞表面存在特异性高表达,可以将IL-13及其受体应用于某些恶性肿瘤的诊断和免疫治疗等. 相似文献
995.
背景与目的:鞍区巨大肿瘤手术难度较大,本文探索前纵裂入路切除鞍内、鞍上向单双侧海绵窦、第三脑室、蝶窦及伴颞叶发展的巨大肿瘤的手术适应症、方法与优缺点方法:总结分析2002年1月至2004年5月我科经前纵裂入路切除鞍区各部位发展的肿瘤17例。结果:肿瘤全切14例,近全切2例.部分切除1例;术后视力改善12例,无改变5例,尿崩或电解质紊乱8例,死亡1例,随访时间3~32个月,有1例复发,系巨大侵袭性垂体瘤术后,行γ-刀治疗后肿瘤基本得到控制。结论:前纵裂入路是切除鞍内、鞍上向单双侧海绵安、第三脑室、蝶窦及伴颞叶发展的肿瘤较理想的入路,利用自然脑裂的分离,手术视野、操作角度好、肓区少,有利于显露重要血管、神经及双侧海绵窦内侧壁,肿瘤全切率高。 相似文献
996.
OBJECTIVE Radiation-induced lung injury commonly follows radiotherapy (RT) fortumors within and near the thorax. Lung function is usually measured by pulmonary function tests (PFTs). But RT-induced regional changes of pulmonary function cannot be accurately evaluated by PFTs. Lung perfusion scintigraphy compared with other radiographic methods can assess well regional pulmonary physiological function, and a 3-dimensional conformal radiotherapy planning system can quantitatively calculate irradiation dosage. The purpose of this study is to assess, by lung perfusion scintigraphy, early changes in the pulmonary function of patients with lung cancer when receiving thoracic 3-dimensional conformal radiotherapy (3D-CRT).METHODS Nineteen patients receiving thoracic 3D-CRT for lung cancer were studied. A single photon emission computed tomography (SPECT)lung perfusion scan, X-ray or CT scan before RT and after 40~50Gy radiation were performed. Pre-RT SPECT lung perfusion images were classified by comparing lung perfusion defects with radiological abnormalities before RT. Grade 0: There was no lung perfusion defect in the area of radiological abnormality. Grade 1: The size of the radiological abnormality was similar to the area of the lung perfusion defect. Grade 2: The area of the lung perfusion defect was bigger than the size of the radiological abnormality and extended to one lobe of the lung. Grade 3: The area of lung perfusion defect exceeded one lobe of the lung. The radiation field with more than 20 Gy was drawn as a region of interest (ROI). The proportion of radioactive dose within this ROI relative to total lung dose in one slice was calculated.RESULTS All patients had lung perfusion defects, nine patients with grade 1,five patients with grade 2 and five patients with grade 3 damage,respectively. All tumors in the 19 patients were reduced in CT or X-ray images to various degrees after 40~50 Gy radiation. The mean proportion of ROI in 19 patients was 53.7±29.8% before radiation as compared to 57.6±22.6% during RT. The difference between these two groups was not significant (P=0.280). The decreased relative lung perfusion post-RT was found in six patients, whereas the increased relative lung perfusion post-RT was observed in 13 patients.CONCLUSION SPECT lung perfusion scaning is a simple, convenient and useful method for assessing regional lung function pre-RT and for monitoring the changes in regional lung function after irradiation. 相似文献
997.
目的:观察针刺治疗功能性消化不良的临床疗效.方法:根据中医经络理论选择以足三里等穴位,用平补平泻手法,辅以电针治疗功能性消化不良,并以常用西药多潘立酮作为对照进行临床观察.结果与结论:针刺组总有效率93.8%,显效率为63.3%,药物组分别为82.3%和43.1%,针刺组治疗非特异型功能性消化不良疗效好于药物组(P<0.05);治疗动力障碍型者,两者无明显差异(P>0.05),疗效均较突出. 相似文献
998.
999.
1000.