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排序方式: 共有473条查询结果,搜索用时 15 毫秒
81.
Hogg RJ Delucchi A Sakihara G Wells TG Tenney F Batisky DL Blumer JL Vogt BA Lo MW Hand E Panebianco D Rippley R Shaw W Shahinfar S 《Pediatric nephrology (Berlin, Germany)》2007,22(5):695-701
The pharmacokinetic (PK) parameters of lisinopril were obtained in 46 children aged 6 months to 15 years. A lisinopril suspension
(0.15 mg/kg per day) was administered to patients <6 years of age; the remaining children received lisinopril tablets, the
daily dose being adjusted according to body weight, i.e., 2.5 mg if <25 kg, 5 mg if 25–45 kg, and 10 mg if >45 kg. Blood was
drawn predose and on eight occasions postdose in children aged 4–15 years, and on five occasions in those aged <4 years. PK
data are reported for the 46 children in terms of age groups: Group I (n = 9), aged 6–23 months; Group II (n = 8), aged 2–5 years; Group III (n = 12), aged 6–11 years; Group IV (n = 17), aged 12–15 years. The dose of lisinopril ranged from 3.07 mg/m2 per day in Group I to 4.78 mg/m2 per day in Group IV. Cmax of lisinopril, which occurred 5–6 h postdose, varied from 22 ng/ml in Groups I and II to 44 ng/ml in Groups III and IV; AUC0–24 h ranged from 301–311 ng·h/ml in Groups I and II to 550–570 ng·h/ml in Groups III and IV. No serious adverse events related
to lisinopril were reported. 相似文献
82.
Axillary Reverse Mapping (ARM): A New Concept to Identify and Enhance Lymphatic Preservation 总被引:5,自引:3,他引:2
Thompson M Korourian S Henry-Tillman R Adkins L Mumford S Westbrook KC Klimberg VS 《Annals of surgical oncology》2007,14(6):1890-1895
Background Variations in arm lymphatic drainage put the arm lymphatics at risk for disruption during axillary lymph node surgery. Mapping
the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics
and subsequent lymphedema.
Methods This institutional review board (IRB)-approved study from May to October 2006 involved patients undergoing SLNB and/or ALND.
Technetium sulfur colloid (4 mL) was injected in the subareolar plexus and 2–5 mL of blue dye intradermally was injected in
the ipsilateral upper extremity (ARM). Data were collected on variations in lymphatic drainage that impacted SLNB or ALND,
successful identification and protection of the arm lymphatics, any crossover between a hot breast node and a blue arm node,
and occurrence of lymphedema.
Results Of the 40 patients undergoing surgery for breast cancer, 18 required an ALND, with a median age of 49.7 years old. Fourteen
patients had a SLNB + ALND, and four patients had ALND alone. In 100% of patients, all breast SLNs were hot but not blue,
and the false negative rate was 0. In 11 of 18 ALNDs (61%) blue lymphatics or blue nodes were identified in the axilla. In
the initial seven cases with positive lymph nodes in the axilla, the blue node draining from the arm was biopsied and all
were negative.
Conclusions ARM identified significant lymphatic variations draining the upper extremities and facilitated preservation in all but one
case. ARM added to present-day ALND and SLNB further defines the axilla and may be useful to prevent lymphedema.
Supported by the Susan G. Komen Breast Cancer Clinical Fellowship and the Arkansas Breast Cancer Act 相似文献
83.
84.
Janaica EJ Grispen Gaby Ronda Geert-Jan Dinant Nanne K de Vries Trudy van der Weijden 《BMC public health》2011,11(1):112
Background
Although self-tests are increasingly available and widely used, it is not clear whether their use is beneficial to the users, and little is known concerning the determinants of self-test use. The aim of this study was to identify the determinants of self-test use for cholesterol, glucose, and HIV, and to examine whether these are similar across these tests. Self-testing was defined as using in-vitro tests on body materials, initiated by consumers with the aim of diagnosing a particular disorder, condition, or risk factor for disease. 相似文献85.
86.
Community health centers and community development financial institutions share similar origins and missions and are increasingly working together to meet community needs. Addressing the social and economic determinants of health is a common focus. The availability of new federal grants and tax credits has led these financial institutions to invest in the creation and expansion of community health centers. This article reviews the most recent trends in these two sectors and explores opportunities for further collaboration to transform the health and well-being of the nation's low-income communities. 相似文献
87.
89.
Joan Carles Ronda Angels Serra Virginia Cdiz 《Macromolecular chemistry and physics.》1997,198(9):2917-2934
A series of p-substituted glycidyl phenyl ethers 1 IUPAC nomenclature: 2,3-epoxypropyl phenyl ether. with electron donor groups was prepared using a multistep synthetic method. These compounds were polymerized using four of the most common aluminium-based coordinative initiators, (C2H5)3Al/H2O (the Vandenberg catalyst), (C2H5)3Al/CH3COCH2COCH3/H2O (the Vandenberg chelate catalyst), [(CH3)2CHO&]2Al? O? Zn? O? Al[OCH(CH3)2]2 (the Teyssié catalyst) and [(CH3)2CHO]3AV/ZnCI2 (the Price catalyst), all with different Lewis acid character. The influence of the electron-donor group on the characteristics and conversion was studied. Generally speaking, both the Vandenberg and the Teyssié catalysts yield mostly an insoluble polymer fraction, whereas the Price catalyst was shown to be the most stereoselective catalyst. Moreover, the Vandenberg chelate catalyst gave the highest molecular weight, the Price catalyst the lowest. Thermal characteristics of polymers were studied by means of differential thermal analysis to obtain glass transition temperatuures, melting temperatures and fusion enthalpies. 相似文献
90.
J. M. Portol s G. Ojeda M. Ronda J. C. Leza J. M. Rojo 《Immunological investigations》1995,24(4):643-652
Implantation of pellets containing 75 mg of morphine induced short term (4 day) morphine dependence and markedly reduced total number of spleen cells of BALB/c mice, without affecting total body or liver weight. Polyclonal responses induced by anti-CD3 antibodies, Concanavalin A or Escherichia coli lipopolysaccharide in the remaining spleen cells of morphine-treated mice were also inhibited. Cytofluorimetric analysis indicated that the proportion of major functional lymphocyte populations (Ig+, CD3+, CD4+ and CD8+ lymphocytes) were not significatively changed in the spleen from morphine-dependent mice. Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice. So, morphine dependence in BALB/c mice under these controlled conditions results in a specific defect in lymphoid cell number and function, with no incidence on body weight or particular lymphocyte subsets. 相似文献