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91.
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Snigdha S Christie LA De Rivera C Araujo JA Milgram NW Cotman CW 《Age (Dordrecht, Netherlands)》2012,34(1):67-73
Aging has been shown to disrupt performance on tasks that require intact visual search and discrimination abilities in human
studies. The goal of the present study was to determine if canines show age-related decline in their ability to perform a
novel simultaneous visual search task. Three groups of canines were included: a young group (N = 10; 3 to 4.5 years), an old group (N = 10; 8 to 9.5 years), and a senior group (N = 8; 11 to 15.3 years). Subjects were first tested for their ability to learn a simple two-choice discrimination task, followed
by the visual search task. Attentional demands in the task were manipulated by varying the number of distracter items; dogs
received an equal number of trials with either zero, one, two, or three distracters. Performance on the two-choice discrimination
task varied with age, with senior canines making significantly more errors than the young. Performance accuracy on the visual
search task also varied with age; senior animals were significantly impaired compared to both the young and old, and old canines
were intermediate in performance between young and senior. Accuracy decreased significantly with added distracters in all
age groups. These results suggest that aging impairs the ability of canines to discriminate between task-relevant and -irrelevant
stimuli. This is likely to be derived from impairments in cognitive domains such as visual memory and learning and selective
attention. 相似文献
94.
Makani H Messerli FH Romero J Wever-Pinzon O Korniyenko A Berrios RS Bangalore S 《The American journal of cardiology》2012,110(3):383-391
Angioedema is a rare, potentially life-threatening adverse event of renin-angiotensin system inhibitors. The objective of the present study was to determine the risk of angioedema from randomized clinical trials. A PubMed/CENTRAL/EMBASE search was made for randomized clinical trials from 1980 to October 2011 in patients on angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or direct renin inhibitor (DRI). Trials with a total number of patients ≥100 and a duration of ≥8 weeks were included for analysis. Incidence of angioedema was pooled by weighing the incident rate of each trial by the inverse of the variance. Twenty-six trials with 74,857 patients in the ACE inhibitor arm with 232,523 person-years of follow-up, 19 trials with 35,479 patients on ARB with 122,293 person-years of follow-up, and 2 trials with 5,141 patients on DRI with 1,735 person-years of follow-up met the inclusion criteria and were included in the analysis. In head-to-head comparison in 7 trials, risk of angioedema with ACE inhibitors was 2.2 times higher than with ARBs (95% confidence interval [CI] 1.5 to 3.3). With ACE inhibitors and ARBs, incidence of angioedema was higher in heart failure trials compared to hypertension or coronary artery disease trials without heart failure (p <0.0001). Weighted incidence of angioedema with ACE inhibitors was 0.30% (95% CI 0.28 to 0.32) compared to 0.11% (95% CI 0.09 to 0.13) with ARBs, 0.13% (95% CI 0.08 to 0.19) with DRIs, and 0.07% with placebo (95% CI 0.05 to 0.09). In conclusion, incidence of angioedema with ARBs and DRI was <1/2 than that with ACE inhibitors and not significantly different from placebo. Incidence of angioedema was higher in patients with heart failure compared to those without heart failure with ACE inhibitors and ARBs. 相似文献
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96.
Dog bites represent lesions commonly found in Hospital Emergency Clinic. This type of lesion may cause severe harm to patients, but it rarely affects the underlying bone structure causes facial fracture. This study aims to illustrate a rare clinical case in which a pediatric patient presented a comminuted fracture in the mandible which evolved into a unilateral avulsion of the mandibular condyle, body fractures as well as a mandibular ramus and hemiface that had been deformed, with multiple lacerations and loss of soft-tissue mass. Intermaxillary fixation was performed using the Ivy method, followed by internal rigid fixation using miniplates and screws in attempt to reconstruct the child's mandible. After 2 years of follow-up, a satisfactory esthetics and functional results could be observed. 相似文献
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98.
Leandro Valiengo M.D. Isabela Martins Benseñor M.D. Ph.D. Alessandra C. Goulart M.D. Ph.D. Janaina Farias de Oliveira B.S. Tamires Araujo Zanao B.S. Paulo Sérgio Boggio Ph.D. Paulo Andrade Lotufo M.D. Ph.D. Felipe Fregni M.D. Ph.D. André Russowsky Brunoni M.D. Ph.D. 《Depression and anxiety》2013,30(7):646-653
99.
Araujo VP Aguiar-Oliveira MH Oliveira JL Rocha HM Oliveira CR Rodrigues TM Nunes MA Britto IM Ximenes R Barreto-Filho JA Meneguz-Moreno RA Pereira RM Valença EH Oliveira-Neto LA Vicente TA Blackford A Salvatori R 《European journal of endocrinology / European Federation of Endocrine Societies》2012,166(6):977-982
100.
We compared outcomes of alveolar hemorrhage (AH) in juvenile (JSLE) and adult onset SLE (ASLE). From 263 JSLE and 1522 ASLE, the AH occurred in 13 (4.9%) and 15 (1.0%) patients, respectively (p?.001). Both groups had comparable disease duration (2.6?±?3.0 vs. 5.6?±?7.0 years, p?=?.151) and median SLEDAI scores [17.5 (2 to 32) vs. 17.5 (3 to 28), p?=?1.000]. At AH onset, a higher frequency of JSLE were already on a high prednisone dose (?>?0.5 mg/kg/day) compared to ASLE (54% vs. 15%, p?=?.042). The mean drop of hemoglobin was significantly lower in JSLE (2.9?±?0.9 vs. 5.5?±?2.9 g/dL, p?=?.006). Although treatments with methylprednisolone, plasmapheresis, intravenous immunoglobulin and cyclophosphamide were similar in both groups (p?>?.050), regarding outcomes, there was a trend in high frequency of mechanical ventilation use (85% vs. 47%, p?=?.055) and also significant mortality (69% vs. 13%, p?=?.006) in JSLE compared to ASLE. The sepsis frequency was comparable in both groups (50% vs. 27%, p?=?.433). We have identified that AH in JSLE has a worse outcome most likely related to respiratory failure. The AH onset in JSLE already treated with high-dose steroids raises the concern of inadequate response to this treatment and reinforces the recommendation of early aggressive alternative therapies in this group of patients. 相似文献