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981.
Emmanuel T. Quien Bruce Wallach Linda Sandhaus Pamela Kidd Roger Strair Parvin Saidi 《American journal of hematology》1996,53(4):267-271
We present the case of a 67-year-old male with primary extramedullary leukemia of the prostate gland, the first reported case in the literature to the best of our knowledge. His initial symptoms consisted of episodes of urinary retention. He underwent transurethral resection of the prostate, and a diagnosis of high-grade lymphoma was rendered. He then received a course of doxorubicin-based lymphoma chemotherapy regimen. However, based on a panel of immunocytochemical stains, a diagnosis of extramedullary leukemia or chloroma was confirmed. His bone-marrow examination at this point was normal. He underwent radiation therapy to the prostate with a total dose of 3960 cGy. Seven months after his initial presentation, he progressed to acute nonlymphocytic leukemia (ANLL), M2 by FAB classification. He was successfully treated with induction and consolidation chemotherapy with Ara-C and idarubicin, and was maintained in complete remission up to 19 months of follow-up. Eight other cases of prostatic leukemia reported in the literature are presented. Five cases occurred in association with ANLL, 2 cases as sites of ANLL relapse, and 1 case in association with myelodysplasia. The use of immunohistochemical stains has aided us in diagnosis of extramedullary leukemia. Surgery, radiation therapy, and chemotherapy play complementary roles in the treatment of prostatic extramedullary leukemia. © 1996 Wiley-Liss, Inc. 相似文献
982.
Geoffrey McCowage Robert Tien Roger McLendon Gary Felsberg Herbert Fuchs Michael L. Graham Joanne Kurtzberg Albert Moghrabi Lee Ferrell Tracy Kerby Margaret Duncan-Brown Elizabeth Stewart Patricia L. Robertson O. Michael Colvin Barry Golembe Darrell D. Bigner Henry S. Friedman 《Pediatric blood & cancer》1996,27(1):32-39
Leptomeningeal dissemination of childhood pilocytic astrocytoma (PA) is a rare event with little information available regarding therapy. We report here four children with disseminated PA whom we treated with high doses of cyclophosphamide with clinical benefit. The patients were aged 2.5 to 8 years. Three patients presented with PA localized in the posterior fossa, initially treated with surgical resection (n = 3) and radiotherapy (n = 1). Leptomeningeal dissemination occurred at 32, 44, and 8 months from diagnosis, respectively. The fourth patient presented with an optic pathway tumor with leptomeningeal dissemination at diagnosis. At commencement of cyclophosphamide therapy, disease was present in the subarachnoid space (intracranial, n = 2; spinal, n = 4), cerebral ventricles (n = 2), and primary site (n = 3). Histology was identical at diagnosis and recurrence in the two biopsied cases and cerebrospinal fluid was negative in all cases. Treatment was with cyclophosphamide 4–5 g/m2/cycle given every 4 weeks for a total of two cycles (n = 1) and four cycles (n = 3). One patient achieved disease stabilization (duration 27 months at the time of publication) and three patients experienced significant reductions in tumor burden. Subsequent intrathecal therapy was administered to two patients. Two patients developed disease progression at 10 and 9 months from cessation of chemotherapy. The one re-treated patient responded to further, lower dose, cyclophosphamide. This is the first report of the use of high dose cyclophosphamide for disseminated PA. The recurrence of disease in two cases with a further response to lower dose cyclophosphamide has implications for the optimal duration of therapy for these low grade, aggressive tumors. © 1996 Wiley-Liss, Inc. 相似文献
983.
984.
Jean-Louis Georges Anne Rgis-Bailly Driss Salah Roger Rakotovao Grard Siest Sophie Visvikis Laurence Tiret 《Genetic epidemiology》1996,13(2):179-192
To better characterize the role of the lipoprotein lipase (LPL) gene in the determination of triglyceride levels in healthy subjects, a study was performed in 193 nuclear families (384 parents, means age = 42.0 ± 5.2 years; 399 offspring, mean age = 14.6 ± 4.3 years) volunteering to have a free health checkup examination. The pattern of familial resemblance was compatible with a zero correlation between spouses, a weak father-offspring correlation (0.099 ± 0.054; P < 0.07), and significant mother-offspring (0.235 ± 0.053; P < 10−4) and sib-sib (0.294 ± 0.064; P < 10−4) correlations. Associations of triglyceride levels with the LPL HindIII and PvuII polymorphisms were investigated by a familial measured genotype analysis, specifying sex- and age-dependent polymorphism effects. The effects associated with both polymorphisms were significant only in fathers, the H+ and P+ alleles being associated with raised triglyceride levels. The HindIII and PvuII polymorphisms explained 3.5% and 3%, respectively, of the variability of triglycerides in fathers. The relationship was weakened after prior adjustment on body mass index, but remained significant for PvuII. Because of the lack of effect in mothers and offspring, the polymorphisms did not contribute to the covariance of triglyceride levels in relatives. In conclusion, this family study showed a weak relationship of the HindIII and PvuII polymorphisms to plasma triglyceride levels in young healthy male subjects. The effects detectable only in fathers suggest a possible modulation of the LPL expression by hormonal or lifestyle factors. © 1996 Wiley-Liss, Inc. 相似文献
985.
986.
Lesley C. Ads William B. Knight Roger W. Byard John F. Bateman J. Anthony Desouza Esquivel Roger B.B. Mee Eric A. Haan Dianna M. Milewicz 《American journal of medical genetics. Part A》1996,66(3):289-299
We describe the clinical, histopathologic, and angiographic findings in four children with congenital abnormalities of the great vessels of unknown cause, comprising either single or multiple arterial aneurysms, aortic/arterial dilatation, vessel tortuosity, or combinations of these abnormalities. Two children had early and severe respiratory distress due to aneurysmal compression of the trachea. All children had diffuse dilatation of several arteries, and two children also had tortuosity of multiple arteries. Progression of these abnormalities was clearly evident in one child, in whom diffuse vessel irregularity and tortuosity affected intra-abdominal, and intra and extra-cranial arteries. One child died at 5 years, while the other three have undergone successful surgical repair in the first 3 months of life and are now well, between age 2.5 and 7 years. The phenotype of each child appears unique but all have in common the rare finding of aneurysms of the aorta and main pulmonary artery. Congenital aortic aneurysms did not occur as an isolated finding in any of these children. © 1996 Wiley-Liss, Inc. 相似文献
987.
988.
Franoise M. Brunelle Araz A. Raoof Jean De Ville De Goyet Roger K. Verbeeck 《Biopharmaceutics & drug disposition》1996,17(4):311-317
In vitro glucuronidation was studied in liver microsomes from two patients with Crigler–Najjar type I (CN-I) disease and compared with the activity measured in microsomes prepared from six control human livers. The UDP-glucuronosyltransferase (UGT) activity was determined toward the following substrates: 4-nitrophenol, propofol, (−)-morphine (formation of the 3-glucuronide), and diflunisal (formation of the phenolic and acyl glucuronides). Glucuronidation of 4-nitrophenol was reduced in one of the CN-I livers (CN-I No. 1) (0·9 nmol min−1 mg−1) and normal in the other CN-I liver (CN-I No. 2) (3.5 nmol min−1 mg−1) compared to the control livers (5·6±2·9 nmol min−1 mg−1, mean±S.D.). Propofol glucuronidation was not detectable (i.e. less than 0·100 nmol min−1 mg−1) in the CN-I No. 1 liver and normal in the CN-I No. 2 liver (1·78 nmol min−1 mg−1 against 1·52±0·72 nmol min−1 mg−1 in the control livers). The glucuronidation of (−)-morphine to the 3-glucuronide and the formation of the phenolic and acyl glucuronides of diflunisal were normal in both CN-I livers compared to the control livers. Our results show that CN-I patients are heterogeneous regarding UGT activity toward the phenolic substances 4-nitrophenol and propofol. 相似文献
989.
Ian R. Young Joseph V. Hajnal Idris G. Roberts Junxiao X. Ling Roger J. Hill-Cottingham Angela Oatridge Jason A. Wilson 《Magnetic resonance in medicine》1996,36(3):366-374
Divergencies between chemical shift measurements of temperature and directly measured values using optical sensors have been studied in vivo in human peripheral muscle with the assistance of a variety of experimental and theoretical techniques. These include the modeling of both thermal and susceptibility changes using two- and three-dimensional finite element methods, as well as the use of multi-wavelength near infrared observations. The conclusion of these studies is that a simple temperature calibration is not accessible, with results affected by the complex response of the tissue itself. 相似文献
990.
Susan B Roberts Rachel E Silver Sai Krupa Das Roger A Fielding Cheryl H Gilhooly Paul F Jacques Jennifer M Kelly Joel B Mason Nicola M McKeown Meaghan A Reardon Sheldon Rowan Edward Saltzman Barbara Shukitt-Hale Caren E Smith Allen A Taylor Dayong Wu Fang Fang Zhang Karen Panetta Sarah Booth 《Advances in nutrition (Bethesda, Md.)》2021,12(4):1438