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排序方式: 共有1475条查询结果,搜索用时 15 毫秒
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Shebzukhov YV Koroleva EP Khlgatian SV Lagarkova MA Meshcheryakov AA Lichinitser MR Karbach J Jager E Kuprash DV Nedospasov SA 《Immunology letters》2005,100(1):88-93
Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients. 相似文献
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Jerry R. Nedelman Ekaterina Gibiansky Francis L. S. Tse Christine Babiuk 《Journal of pharmacokinetics and pharmacodynamics》1993,21(3):323-334
Five major objectives for pharmacokinetic investigations in support of toxicity studies are identified as follows: Assess whether animals exhibited measurable blood concentrations in a dose-dependent manner; estimate average area under the concentration- time curve (AUC)and maximal concentration (C
max
)for each treatment group; elucidate general patterns in the concentration-time (CxT)profile, and summarize relationships between CxTand treatment group; determine CxTdependence on day into study; and judge interanimal variability and identify any animals with unusual concentration response. Such objectives are generally addressed in rodent toxicity studies by including satellite animals in the study. Satellite animals are extra animals dosed as per protocol but not subjected to toxicological and pathological observations and tests. Instead, they are used exclusively for the evaluation of pharmacokinetic characteristics of the test compound. In this paper, methods are described for achieving the five listed pharmacokinetic objectives in rodent toxicity studies without the use of satellite animals. A rat toxicity study is presented as an example. 相似文献
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Aleksey Bychkov Vyacheslav Koptev Varvara Zaharova Polina Reshetnikova Elena Trofimova Elena Bychkova Ekaterina Podgorbunskikh Oleg Lomovsky 《Nutrients》2022,14(10)
This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts). 相似文献
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Satsuki Komoda Takeshi Komoda Ekaterina Ivanitskaia-Kuehn Stephan Dreysse Miralem Pasic Roland Hetzer 《General thoracic and cardiovascular surgery》2010,58(2):78-81
We describe the case of a 67-year-old man with a rare combination of a giant coronary artery aneurysm with a fistula draining
into the coronary sinus. The patient presented with a sensation of retrosternal pressure. He was examined by coronary angiography,
which revealed a large aneurysm of the right coronary artery (RCA) with a fistula. This fistula originated from the distal
RCA shortly beyond the crux and drained into the coronary sinus. The aneurysm was in the proximal portion of the RCA, measuring
4 cm in diameter and 7 cm in length. Surgical repair by closure of the fistula under direct vision, suture closure and plication
of the aneurysm, and coronary artery bypass was performed. Postoperative echocardiography and computed tomography confirmed
closure of the fistula. The patient remains symptom-free at 4 months after surgery. 相似文献
8.
Ekaterina A. Grebenik Leonid P. Istranov Elena V. Istranova Semyon N. Churbanov Boris S. Shavkuta Ruslan I. Dmitriev Nadezhda N. Veryasova Svetlana L. Kotova Alexander V. Kurkov Anatoly B. Shekhter Peter S. Timashev 《Xenotransplantation》2019,26(3)
Decellularized bovine pericardium (DBP)‐based biomeshes are the gold standard in reconstructive surgery. In order to prolong their stability after the transplantation, various chemical cross‐linking strategies are employed. However, structural and functional properties of the biomeshes differ in dependence on the cross‐linker used. Here, we performed a bottom‐up study of structural and functional alterations of DBP‐based biomeshes following cross‐linking with hexamethylene diisocyanate (HMDC), ethylene glycol diglycidyl ether (EGDE), 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide (EDC) and genipin. The in vitro cytotoxicity tests supported their clinical applicability. Their structural differences (eg roughness, fibre thickness, pore morphology) were evaluated using the two‐photon confocal laser scanning, atomic force, scanning electron and polarized light microscopies. HMDC and EDC samples appeared to be the roughest. Complex mechanical trials indicated the tendency to reduced Young’s Modulus and mechanical anisotropy values of DBP upon cross‐linking. The lowest mechanical anisotropy was found in EDC and genipin sample groups. In vitro collagenase susceptibility was the highest for EDC samples and the lowest for EGDE samples. The comparative analysis of the results allowed us to recognize the strengths and weaknesses of each cross‐linker in relation to a particular clinical application. 相似文献
9.
Abnormalities of the executive control network in multiple sclerosis phenotypes: An fMRI effective connectivity study 下载免费PDF全文
Ekaterina Dobryakova Maria Assunta Rocca Paola Valsasina Angelo Ghezzi Bruno Colombo Vittorio Martinelli Giancarlo Comi John DeLuca Massimo Filippi 《Human brain mapping》2016,37(6):2293-2304
The Stroop interference task is a cognitively demanding task of executive control, a cognitive ability that is often impaired in patients with multiple sclerosis (MS). The aim of this study was to compare effective connectivity patterns within a network of brain regions involved in the Stroop task performance between MS patients with three disease clinical phenotypes [relapsing‐remitting (RRMS), benign (BMS), and secondary progressive (SPMS)] and healthy subjects. Effective connectivity analysis was performed on Stroop task data using a novel method based on causal Bayes networks. Compared with controls, MS phenotypes were slower at performing the task and had reduced performance accuracy during incongruent trials that required increased cognitive control. MS phenotypes also exhibited connectivity abnormalities reflected as weaker shared connections, presence of extra connections (i.e., connections absent in the HC connectivity pattern), connection reversal, and loss. In SPMS and the BMS groups but not in the RRMS group, extra connections were associated with deficits in the Stroop task performance. In the BMS group, the response time associated with correct responses during the congruent condition showed a positive correlation with the left posterior parietal → dorsal anterior cingulate connection. In the SPMS group, performance accuracy during the congruent condition showed a negative correlation with the right insula → left insula connection. No associations between extra connections and behavioral performance measures were observed in the RRMS group. These results suggest that, depending on the phenotype, patients with MS use different strategies when cognitive control demands are high and rely on different network connections. Hum Brain Mapp, 37:2293–2304, 2016. © 2016 Wiley Periodicals, Inc. 相似文献