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Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents 总被引:2,自引:1,他引:1 下载免费PDF全文
Flynn PM Rodman J Lindsey JC Robbins B Capparelli E Knapp KM Rodriguez JF McNamara J Serchuck L Heckman B Martinez J;PACTG P Team 《Antimicrobial agents and chemotherapy》2007,51(10):3516-3522
Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations of ZDV and 3TC during chronic therapy on a QD regimen. Human immunodeficiency virus-infected patients (12 to 24 years) taking ZDV (600 mg/day) and 3TC (300 mg/day) as part of a highly active antiretroviral therapy regimen received QD and BID regimens of ZDV and 3TC for 7 to 14 days in a crossover design. Serial blood samples were obtained over 24 h on the QD regimen. Intracellular mono-, di-, and triphosphates for ZDV and 3TC were measured. The median ratio of BID/QD for ZDV-TP predose concentrations was 1.28 (95% confidence interval [CI] = 1.00 to 2.45) and for 3TC-TP was 1.12 (95% CI = 0.81 to 1.96). The typical population estimated half-lives (+/- the standard error of the mean) were 9.1 +/- 0.859 h for ZDV-TP and 17.7 +/- 2.8 h for 3TC-TP. Most patients had detectable levels of the TP of ZDV (24 of 27) and 3TC (24 of 25) 24 h after dosing, and half-lives on a QD regimen were similar to previously reported values when the drugs were given BID. Lower, but not significantly different, concentrations of ZDV-TP were demonstrated in the QD regimen compared to the BID regimen (P = 0.056). Although findings were similar between the BID and QD groups, the lower concentrations of ZDV and the number of patients below the level of detection after 24 h suggests that ZDV should continue to be administered BID. 相似文献
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Mumun Sinha MD Niraj N. Pandey MD S. H. Chandrashekhara MD Arun Sharma DM 《Journal of cardiac surgery》2020,35(7):1644-1646
We present a case of cyanotic congenital heart disease with left common carotid artery agenesis in the setting of the right aortic arch highlighting the potential implications in management. 相似文献
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Sachin Talwar MS MCh Niwin George MS MCh Shyam Sunder Kothari MD DM Abhishek Sharma MS Keerthi Goondla MS Shiv Kumar Choudhary MS MCh 《Journal of cardiac surgery》2020,35(7):1690-1693
Rupture of sinus of valsalva following repair of tetralogy of fallot (TOF) is very rare. It should be suspected as a cause of recurrent or prolonged pleural effusion and congestive cardiac failure in patients who have undergone repair of TOF. We report one such patient. 相似文献
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Vineeta Ojha MD Sh Chandrashekhara DM Amarinder Singh Malhi DM Sanjeev Kumar MD 《Journal of cardiac surgery》2020,35(6):1340-1341
We present images from computed tomography angiography in a 40-year-old female with a calcified pseudo-aneurysm in her left coronary artery, who had previously undergone repair of tetralogy of Fallot. 相似文献
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Niraj Nirmal Pandey DM Mumun Sinha MD Sanjeev Kumar MD 《Journal of cardiac surgery》2020,35(7):1624-1625
We present a case of type B aortic dissection with a rare aortic arch branching variation whereby two separate brachiocephalic trunks arise from the arch. This case also highlights the potential implications of this variant in the management of thoracic aortic dissections and aneurysms. 相似文献