全文获取类型
收费全文 | 775篇 |
免费 | 39篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 31篇 |
妇产科学 | 6篇 |
基础医学 | 123篇 |
口腔科学 | 2篇 |
临床医学 | 80篇 |
内科学 | 224篇 |
皮肤病学 | 7篇 |
神经病学 | 53篇 |
特种医学 | 133篇 |
外科学 | 38篇 |
综合类 | 51篇 |
预防医学 | 19篇 |
眼科学 | 2篇 |
药学 | 32篇 |
中国医学 | 3篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 6篇 |
2022年 | 4篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 13篇 |
2017年 | 3篇 |
2016年 | 14篇 |
2015年 | 14篇 |
2014年 | 14篇 |
2013年 | 25篇 |
2012年 | 32篇 |
2011年 | 27篇 |
2010年 | 20篇 |
2009年 | 26篇 |
2008年 | 31篇 |
2007年 | 46篇 |
2006年 | 23篇 |
2005年 | 32篇 |
2004年 | 31篇 |
2003年 | 27篇 |
2002年 | 27篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 22篇 |
1998年 | 49篇 |
1997年 | 39篇 |
1996年 | 22篇 |
1995年 | 15篇 |
1994年 | 14篇 |
1993年 | 16篇 |
1992年 | 5篇 |
1991年 | 8篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 14篇 |
1987年 | 12篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 6篇 |
1983年 | 8篇 |
1982年 | 12篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 4篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 3篇 |
1961年 | 1篇 |
1943年 | 1篇 |
排序方式: 共有826条查询结果,搜索用时 15 毫秒
31.
High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance‐associated substitutions in hepatitis C genotype 3 infection 下载免费PDF全文
32.
Emblem KE Scheie D Due-Tonnessen P Nedregaard B Nome T Hald JK Beiske K Meling TR Bjornerud A. 《中国神经肿瘤杂志》2008,6(2):84-84
BACKGROUND AND PURPOSE: Inclusion of oligodendroglial tumors may confound the utility of MR based glioma grading. Our aim was, first, to assess retrospectively whether a histogram-analysis method of MR peifusion images may both grade gliomas and differentiate between low-grade oligodendroglial tumors with or without loss of heterozygosity (LOH) on 1p/19q and, second, to assess retrospectively whether low-grade oligodendroglial subtypes can be identified in a population of patients with high-grade and low-grade astrocytic and oligodendroglial tumors. 相似文献
33.
Schmidt-Wolf IG Rockstroh JK Schlegel U Pels H Weiss R Huhn D 《European journal of medical research》2002,7(7):295-303
Despite of changes in the use of antiviral or chemotherapy regimens, the median survival of patients with AIDS-related lymphoma has not significantly changed until recently. However, partly due to prolonged survival with the introduction of highly active antiretroviral therapy (HAART) prognosis in AIDS patients with lymphoma seems to improve. Recently, several new treatment options have been explored in patients with lymphoma. It is hoped that novel strategies will lead to a survival benefit in these patients. In this review, we discuss the current strategies for the treatment of AIDS-related lymphoma. 相似文献
34.
Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV-HCV International Panel 总被引:11,自引:0,他引:11
35.
36.
Wang WS; Fan FS; Hsieh RK; Chiou TJ; Lin JK; Lin TC; Yen CC; Liu JH; Hsu H; Chen PM 《Japanese journal of clinical oncology》1997,27(3):174-179
5-Fluorouracil in combination with leucovorin has been shown to be active
in therapeutic trials of metastatic colorectal carcinoma. In this study, we
administered these drugs to 72 patients with metastatic colorectal
carcinoma. Thirty-six of them without previous exposure to 5-fluorouracil
were treated with weekly bolus injections of 5-fluorouracil (425 mg/m2) and
leucovorin (25 mg/m2) supplemented with oral levamisole. Another 36
patients with or without prior 5-fluorouracil treatment received
5-fluorouracil 3,000 mg/m2 and leucovorin 300 mg/m2 in a 48-hour continuous
infusion every two weeks. Clinical efficacy and toxicity were assessed by
WHO criteria. Variables were tested for relations to response and survival
by univariate and multivariate analysis. The response rate was 19.4% in
weekly bolus arm and 13.9% in biweekly high-dose infusion arm (P = 0.527).
Median survivals in the two arms were 18.4 months (weekly) and 21 months
(biweekly) respectively (P = 0.708). Gastrointestinal side effects
including nausea, vomiting, diarrhea and mucositia were the major
toxicities of these regimens. By multivariate analysis, the only factor to
influence response rate was the site of metastases (P = 0.009). The only
factor to affect survival was performance status of the patient (P =
0.0001). We concluded that the two 5-fluorouracil based regimens are
well-tolerated and shown to have a response rate comparable with previous
reports of similar regimens in patients with metastatic colorectal cancer.
Only liver metastases seemed to have a better response to therapy.
Performance status is the most important prognostic factor in patients with
metastatic colorectal cancer.
相似文献
37.
38.
Recent reports have demonstrated that the HIV-1 transactivator protein,tat, induces apoptosis in T-lymphocyte cell lines, as well as in peripheral blood mononuclear cells, and stimulates a cascade
of events resulting in up-regulation of the potent immunosuppressive cytokine, transforming growth factor-β (TGF-β). In this
study we evaluated the ability of TGF-β to mediatetat induced apoptosis in T-lymphocyte cell lines. T-cells treated exogenously with either TGF-β1 or a combination of tat and
pan-specific TGF-β neutralizing antibodies showed little change in the amount of apoptosis. When treated with pan-specific
TGF-β neutralizing antibodies, Jurkat cells that stably expresstat protein (Jurkat-tat) showed only a modest decrease in apoptosis, while CEM-TART cells (CEM T-cells expressing both HIV-1tat andrev) demonstrated little change in the amount of apoptosis. In conclusion, we have demonstrated that TGF-β does not play a significant
role in mediatingtat induced T-cell apoptosis. 相似文献
39.
The reliability of proton spectroscopic imaging in evaluating fatty infiltration of the liver was investigated in 35 subjects (12 healthy volunteers and 23 patients with fatty livers). With this modified spin-echo technique, fatty liver could be separated from normal liver both visually and quantitatively. On the opposed image, normal liver had an intermediate signal intensity, greater than that of muscle, whereas fatty liver had a lower signal intensity, equal to or less than that of muscle. In normal livers, the lipid signal fraction was less than 10%, while in fatty livers it was greater than 10% and usually exceeded 20%. With this technique, nonuniform fatty infiltration of the liver can be differentiated from hepatic metastases, and the technique may prove useful in the differentiation of some hepatic disorders. 相似文献
40.
Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study 总被引:1,自引:1,他引:0
Ahlenstiel G Iwan A Nattermann J Bueren K Rockstroh JK Brackmann HH Kupfer B Landt O Peled A Sauerbruch T Spengler U Woitas RP 《World journal of gastroenterology : WJG》2005,11(48):7631-7638
AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore, these mutations may also affect the course of HIV/HCV coinfection. METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTES-IN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n = 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes. RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%, P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1: 19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002; 1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls. CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. 相似文献