全文获取类型
收费全文 | 178821篇 |
免费 | 11472篇 |
国内免费 | 707篇 |
专业分类
耳鼻咽喉 | 2503篇 |
儿科学 | 4877篇 |
妇产科学 | 3435篇 |
基础医学 | 23192篇 |
口腔科学 | 3546篇 |
临床医学 | 17509篇 |
内科学 | 38297篇 |
皮肤病学 | 2801篇 |
神经病学 | 17952篇 |
特种医学 | 6213篇 |
外国民族医学 | 13篇 |
外科学 | 26475篇 |
综合类 | 2301篇 |
现状与发展 | 3篇 |
一般理论 | 201篇 |
预防医学 | 13295篇 |
眼科学 | 4781篇 |
药学 | 11513篇 |
中国医学 | 203篇 |
肿瘤学 | 11890篇 |
出版年
2023年 | 697篇 |
2022年 | 1225篇 |
2021年 | 2863篇 |
2020年 | 1761篇 |
2019年 | 2886篇 |
2018年 | 3396篇 |
2017年 | 2453篇 |
2016年 | 2859篇 |
2015年 | 3455篇 |
2014年 | 5107篇 |
2013年 | 7878篇 |
2012年 | 11387篇 |
2011年 | 12248篇 |
2010年 | 6837篇 |
2009年 | 6304篇 |
2008年 | 11530篇 |
2007年 | 12297篇 |
2006年 | 11797篇 |
2005年 | 12159篇 |
2004年 | 11551篇 |
2003年 | 11026篇 |
2002年 | 10635篇 |
2001年 | 1484篇 |
2000年 | 1124篇 |
1999年 | 1592篇 |
1998年 | 2329篇 |
1997年 | 2020篇 |
1996年 | 1703篇 |
1995年 | 1581篇 |
1994年 | 1424篇 |
1993年 | 1352篇 |
1992年 | 1041篇 |
1991年 | 951篇 |
1990年 | 834篇 |
1989年 | 818篇 |
1988年 | 838篇 |
1987年 | 718篇 |
1986年 | 837篇 |
1985年 | 915篇 |
1984年 | 1221篇 |
1983年 | 1173篇 |
1982年 | 1639篇 |
1981年 | 1512篇 |
1980年 | 1416篇 |
1979年 | 785篇 |
1978年 | 906篇 |
1977年 | 800篇 |
1976年 | 707篇 |
1975年 | 566篇 |
1974年 | 593篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
941.
Ekman-Westborg and Julin [1974: Oral Surg 38:217-222], described multiple macrodontia and multituberculism affecting the teeth without other anomalies (E-WJ). We describe a Chilean case in a 12-year-old with the typical dental alterations and with histopathologic findings that include absence of predentin layer and prominent reduced enamel epithelium. E-WJ is not a syndrome and we propose "multiple macrodontic multituberculism" as a better name for this anomaly of uncertain etiology affecting only the crowns of the teeth. 相似文献
942.
Lei Li Christine Eng Robert J. Desnick James German Nathan A. Ellis 《Molecular genetics and metabolism》1998,64(4):286-290
Bloom syndrome is more common in individuals of Ashkenazi Jewish descent than in any other population, and one particular mutation in the Bloom syndrome gene,blmAsh,is homozygous in nearly all Ashkenazi Jewish persons with Bloom syndrome. We have determined the frequency ofblmAshin 1491 Ashkenazi Jewish persons with no known history of Bloom syndrome and found that 1 in 107 persons was heterozygous. Although not common, genetic screening for Bloom syndrome is feasible in this population. 相似文献
943.
The thymic repertoire of neuroendocrine 'self' antigens has been previously described on the basis of the intrathymic expression of neurohypophysial (NHP)- and tachykinin-related peptide signals and receptors. According to that model, the cryptocrine signalling between thymic epithelial/nurse cells and thymocytes through NHP-related signals and receptors constitutes one accessory pathway in the process of T-cell differentiation and/or activation. A pharmacological manipulation of that novel type of cell-to-cell signalling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research Laboratories). These compounds were found to significantly inhibit the productions of cytokines (mainly IL-1 beta and IL-6) elicited by anti-CD3 treatment of human whole blood cell cultures. Cytokine productions were more significantly reduced by OT antagonists in whole blood cell cultures derived from female volunteers than in those obtained from male donors, suggesting an influence of the gonadal steroid environment on the expression of NHP peptide receptors by immune cells. These observations support the concept of novel immunomodulating approaches through immune-specific neuropeptide antagonists, as well as the pharmacological value of such strategies in selective immunotherapy. 相似文献
944.
Atkinson JO Biggar RJ Goedert JJ Engels EA 《Journal of acquired immune deficiency syndromes (1999)》2004,37(2):1282-1287
Some studies report increased prevalence of human herpesvirus 8 (HHV-8), the causative agent of Kaposi sarcoma (KS), among injection drug users (IDUs), suggesting that HHV-8 may be transmitted through blood-borne or other exposures common in this population. Since an elevated HHV-8 prevalence in IDUs would likely lead to increased KS incidence, KS incidence was studied in IDUs and non-IDU's with AIDS. AIDS-related KS cases were identified using linked US AIDS and cancer registry data for 25,891 women, 47,782 heterosexual men, and 90,616 men who have sex with men (MSM). KS arose in 7099 persons with AIDS. KS incidence was highest for MSM (5.7 per 100 person-years), substantially lower for heterosexual men (0.7 per 100 person-years), and lowest for women (0.4 per 100 person-years). After adjustment for age, race, registry location, and year of AIDS onset, relative risks for KS associated with injection drug use were 1.3 (95% CI, 0.9-1.8) among women, 1.1 (0.7-1.6) among heterosexual men, and 0.9 (0.8-0.9) among MSM. It is concluded that injection drug use was not associated with an increased risk of AIDS-related KS. Thus, these data suggest that IDUs' risk of acquiring HHV-8, through needle sharing or other behaviors related to injection drug use, is low. 相似文献
945.
The authors tested the spatial generalization of shape and color discriminations in 2 monkeys, in which 3 visual field quadrants were affected, respectively, by lesions in area V4, TEO, or both areas combined. The fourth quadrant served as a normal control. The monkeys were trained to discriminate stimuli presented in a standard location in each quadrant, followed by tests of discrimination performance in new locations in the same quadrant. In the quadrant affected by the V4 + TEO lesion, the authors found temporary but striking deficits in spatial generalization of shape and color discriminations over small distances, suggesting a contribution of areas V4 and TEO to short-range spatial generalization of visual skills. 相似文献
946.
947.
948.
Per H.B. Carstens MD Cyrus Ghazi MD Robert H. Carnighan MD PhD McHenry S. Brewer MD 《Human pathology》1986,17(12):1282-1285
Biliary tract obstruction in a 30-year-old man was found to be caused by a malignant melanoma in the common bile duct. Melanin pigment was demonstrated by immunohistochemistry and electron microscopy. Extensive search for a primary malignant melanoma elsewhere was unsuccessful. No pigmented lesions had been removed previously. There were junctional changes in the mucosa of the common bile duct close to the tumor. The malignant melanoma in the common bile duct therefore is considered to be primary. Only one other case of primary malignant melanoma in the common bile duct has been described in the literature, whereas metastases to the major bile ducts in one autopsy study of malignant melanoma in the more common locations were found with a frequency of 6 per cent. 相似文献
949.
Gerhard Neuhser Richard F. Daly Norma C. Magnelli Robert F. Barreras Robert M. Donaldson John M. Opitz 《Clinical genetics》1976,9(1):81-91
The familial occurrence of essential tremor combined with (congenital) nystagmus, duodenal ulceration and a narcolepsy-like sleep disturbance caused by an autosomal dominant gene with high penetrance and fairly uniform expressivity is reported in a family of Swedish-Finnish ancestry. Twelve of 17 affected family members had essential tremor which began between 30-40 years of age and which could be controlled temporarily by alcohol; this resulted in alcoholism in several affected individuals. The most severly affected persons showed cerebellar signs which may reflect a possible pathogenetic relationship of the syndrome to the genetic cerebellar atrophies. Nystagmus, observed in 12 of 17 affected family members (eight of whom were also affected with tremor) usually was congenital and accompanied by refractive errors. Duodenal ulcers occurred almost exclusively in individuals with the neurological syndrome, and preceded its onset in some cases. The ulcer disease therefore seems to be a component manifestation of the syndrome and is interpreted as a pleiotropic effect of the gene which also causes the nystagmus, tremor and sleep disturbance. 相似文献
950.
Video-rate nonlinear microscopy of neuronal membrane dynamics with genetically encoded probes 总被引:4,自引:0,他引:4
Biological membranes decorated with suitable contrast agents give rise to nonlinear optical signals such as two-photon fluorescence and harmonic up-conversion when illuminated with ultra-short, high-intensity pulses of infrared laser light. Microscopic images based on these nonlinear contrasts were acquired at video or higher frame rates by scanning a focused illuminating spot rapidly across neural tissues. The scan engine relied on an acousto-optic deflector (AOD) to produce a fast horizontal raster and on corrective prisms to offset the AOD-induced dispersion of the ultra-short excitation light pulses in space and time. Two membrane-bound derivatives of the green fluorescent protein (GFP) were tested as nonlinear contrast agents. Synapto-pHluorin, a pH-sensitive GFP variant fused to a synaptic vesicle membrane protein, provided a time-resolved fluorescent read-out of neurotransmitter release at genetically specified synaptic terminals in the intact brain. Arrays of dually lipidated GFP molecules at the plasma membrane generated intense two-photon fluorescence but no detectable second-harmonic power. Comparison with second-harmonic generation by membranes stained with a synthetic styryl dye suggested that the genetically encoded chromophore arrangement lacked the orientational anisotropy and/or dipole density required for efficient coherent scattering of the incident optical field. 相似文献