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Metin OZKAN Bulent ESER Ozlem ER H. Senol COSKUN Ahmet OZTURK Ismail SARI Ozlem CANOZ Mustafa ALTINBAS 《Asia-Pacific Journal of Clinical Oncology》2006,2(1):32-38
The more metastatic sites and bone marrow metastasis in small cell lung cancer (SCLC), the worse the prognosis. Diagnosing the bone marrow invasion at the beginning of the therapy is important for determining of the prognosis and planning the treatment. Abnormalities of some blood parameters may help to estimate the extent of bone marrow invasion by cancer cells. In this retrospective review, the changes in routine laboratory tests that may indicate bone marrow invasion, the predictive values of these tests, and the prognostic importance of bone marrow invasion were evaluated in SCLC patients who were being followed up according to a protocol. One hundred and forty‐four patients with SCLC were enrolled in this study. Retrospectively, it was evaluated that 25 (17.4%) of the patients had bone marrow metastasis. According to univariate analysis, there was a significant difference between hemoglobin, white blood cell count, platelet count, lactate dehydrogenase, alkaline phosphatase and uric acid of the patients with and without bone marrow involvement. Among the biochemical parameters, the elevated LDH and AP had the highest sensitivity and specificity as indicators of bone marrow invasion (0.80–0.82 and 0.84–0.78, respectively). The median overall survival of extensive‐stage disease with and without bone marrow metastasis were 4.0 ± 1.0 months (95% CI 2.2–5.7) and 7.0 ± 1.2 months (95% CI 4.7–9.3), respectively (P = 0.03). Bone marrow metastasis was found to be an indicator of a bad prognosis. Bone marrow biopsy, that is an invasive procedure, can be performed on selected patients who have changes of routine laboratory tests suggesting bone marrow invasion. 相似文献
73.
Menner Anna Sofia Kinkel Hans-Tilmann Dixit Sameer Morrison Audry Rieke Burkhard Küpper Thomas 《Zeitschrift fur Gesundheitswissenschaften》2021,29(3):481-488
Journal of Public Health - Nepal is a country of low endemicity for chronic hepatitis B, with a prevalence of 0.9%. However, in Dolpo District, a higher prevalence of hepatitis B virus (HBV) was... 相似文献
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A case of sufficient high-frequency jet ventilation with a tip-cut nasogastric tube in a patient requiring endobronchial 192iridium irradiation is described. In order to allow the endotracheal introduction of a bronchoscope together with an 192iridium applicator during anesthesia with mechanical ventilation, the nasogastric tube was used instead of an endotracheal tube for jet ventilation. Using a frequency of 60/min and a fresh-gas flow of 15 l/min, FIO2 = 1.0, normocapnic, normoxemic ventilation could be achieved during the whole procedure. It is concluded that the method can be considered as an alternative in patients with narrow airways, provided that airway-pressure monitoring and bronchoscopy to confirm the position of the tube are employed. 相似文献
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THOMAS MODÉER GÖRAN DAHLLÖF JOHAN KARSTEN PER OTTESKOG 《European journal of oral sciences》1989,97(2):186-187
Abstract – Human mononuclear cells purified by Lymphoprep flotation were incubated with phenytoin (PHT) (20 μg/ml) or its metabolite p-HPPH (2 μg/ml) in the presence of Concanaval-in A (10 μg/ml) in vitro. The results indicate that phenytoin and its metabolite p-HPPH induce the release of a mononuclear cell factor(s) that activates quiescent human gingival fibroblast to synthesize DNA. 相似文献
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Digital subtraction angiography (DSA) of the spinal cord was performed in 6 patients using selective intra-arterial injections of contrast material. Two arteriovenous malformations of the spinal cord, 1 dural fistula, and 1 case of multiple hemangioblastomas were studied. Contrast and spatial resolution were satisfactory for defining normal and abnormal vascularity while reducing examination time, contrast dosage, patient discomfort, and film cost. The only significant limitation was misregistration artifacts seen on lateral views encompassing the diaphragm. 相似文献
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EN Smit JM Dijkstra TA Schnater E Seerat FAJ Muskiet ER Boersma 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(7):690-695
Abstract Erythrocyte fatty acids and plasma vitamin E concentrations were determined in 47 grade 2 and 21 grade 3 malnourished Pakistani children (ages 4–56 months). Data were compared with those of 26 age- and sex-matched apparently healthy controls. Evaluation with three statistical approaches revealed that both grade 2 and grade 3 malnourished children had decreased erythrocyte ω6 fatty acids and to a lesser extent decreased ω3 fatty acids. These decreases were compensated for by increased ω9 fatty acids. The patients tended to have lower plasma vitamin E concentrations. We conclude that malnourished Pakistani children have low essential fatty acid status, notably those of the ω6 series. The combination of low erythrocyte 22:6ω3 and a low 22:5ω6/22:4ω6 ratio in grade 2 patients suggests low Δ4-desaturation activity, which may be due to impaired peroxisomal β-oxidation. 相似文献