全文获取类型
收费全文 | 6517篇 |
免费 | 330篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 144篇 |
妇产科学 | 214篇 |
基础医学 | 817篇 |
口腔科学 | 447篇 |
临床医学 | 366篇 |
内科学 | 1625篇 |
皮肤病学 | 94篇 |
神经病学 | 534篇 |
特种医学 | 197篇 |
外科学 | 969篇 |
综合类 | 20篇 |
一般理论 | 1篇 |
预防医学 | 289篇 |
眼科学 | 139篇 |
药学 | 328篇 |
中国医学 | 28篇 |
肿瘤学 | 596篇 |
出版年
2023年 | 37篇 |
2022年 | 78篇 |
2021年 | 184篇 |
2020年 | 101篇 |
2019年 | 168篇 |
2018年 | 179篇 |
2017年 | 128篇 |
2016年 | 159篇 |
2015年 | 154篇 |
2014年 | 254篇 |
2013年 | 325篇 |
2012年 | 547篇 |
2011年 | 531篇 |
2010年 | 299篇 |
2009年 | 269篇 |
2008年 | 449篇 |
2007年 | 428篇 |
2006年 | 384篇 |
2005年 | 373篇 |
2004年 | 359篇 |
2003年 | 300篇 |
2002年 | 283篇 |
2001年 | 57篇 |
2000年 | 58篇 |
1999年 | 64篇 |
1998年 | 59篇 |
1997年 | 55篇 |
1996年 | 49篇 |
1995年 | 40篇 |
1994年 | 43篇 |
1993年 | 25篇 |
1992年 | 26篇 |
1991年 | 35篇 |
1990年 | 20篇 |
1989年 | 36篇 |
1988年 | 28篇 |
1987年 | 26篇 |
1986年 | 33篇 |
1985年 | 17篇 |
1984年 | 15篇 |
1983年 | 23篇 |
1982年 | 27篇 |
1981年 | 19篇 |
1980年 | 17篇 |
1979年 | 21篇 |
1978年 | 8篇 |
1977年 | 11篇 |
1976年 | 9篇 |
1974年 | 9篇 |
1973年 | 7篇 |
排序方式: 共有6868条查询结果,搜索用时 0 毫秒
81.
Reis AD Fink MC Machado CM Paz Jde P Oliveira RR Tateno AF Machado AF Cardoso MR Pannuti CS;CHIADO RDGV/FAPESP Research Groups 《Revista do Instituto de Medicina Tropical de S?o Paulo》2008,50(1):37-40
A total of 316 samples of nasopharyngeal aspirate from infants up to two years of age with acute respiratory-tract illnesses were processed for detection of respiratory syncytial virus (RSV) using three different techniques: viral isolation, direct immunofluorescence, and PCR. Of the samples, 36 (11.4%) were positive for RSV, considering the three techniques. PCR was the most sensitive technique, providing positive findings in 35/316 (11.1%) of the samples, followed by direct immunofluorescence (25/316, 7.9%) and viral isolation (20/315, 6.3%) (p < 0.001). A sample was positive by immunofluorescence and negative by PCR, and 11 (31.4%) were positive only by RT-PCR. We conclude that RT-PCR is more sensitive than IF and viral isolation to detect RSV in nasopharyngeal aspirate specimens in newborn and infants. 相似文献
82.
Galectina-3 Associada a Formas Graves e Mortalidade em Longo Prazo em Pacientes com Doença de Chagas
Fbio Fernandes Carlos Henrique Valente Moreira Lea Campos Oliveira Marcela Souza-Basqueira Barbara Maria Ianni Claudia di Lorenzo Felix Jos Alvarez Ramires Luciano Nastari Edecio Cunha-Neto Antonio L. Ribeiro Renato Delascio Lopes Sheila M. Keating Ester Cerdeira Sabino Charles Mady 《Arquivos brasileiros de cardiologia》2021,116(2):248
Background The histopathological characteristics of Chagas disease (ChD) are: presence of myocarditis, destruction of heart fibers, and myocardial fibrosis. Galectin-3 (Gal-3) is a biomarker involved in the mechanism of fibrosis and inflammation that may be useful for risk stratification of individuals with ChD.Objectives We sought to evaluate whether high Gal-3 levels are associated with severe forms of Chagas cardiomyopathy (CC) and whether they are predictive of mortality.Methods We studied anti-T. cruzi positive blood donors (BD): Non-CC-BD (187 BD without CC with normal electrocardiogram [ECG] and left ventricular ejection fraction [LVEF]); CC-Non-Dys-BD (46 BD with CC with abnormal ECG but normal LVEF); and 153 matched serum-negative controls. This cohort was composed of 97 patients with severe CC (CC-Dys). We used Kruskall-Wallis and Spearman’s correlation to test hypothesis of associations, assuming a two-tailed p<0.05 as significant.Results The Gal-3 level was 12.3 ng/mL for Non-CC-BD, 12.0 ng/mL for CC-Non-Dys-BD, 13.8 ng/mL for controls, and 15.4 ng/mL for CC-Dys. LVEF<50 was associated with higher Gal-3 levels (p=0.0001). In our linear regression adjusted model, we found association between Gal-3 levels and echocardiogram parameters in T. cruzi-seropositive subjects. In CC-Dys patients, we found a significant association of higher Gal-3 levels (≥15.3 ng/mL) and subsequent death or heart transplantation in a 5-year follow-up (Hazard ratio – HR 3.11; 95%CI 1.21–8.04; p=0.019).Conclusions In ChD patients, higher Gal-3 levels were significantly associated with severe forms of the disease and more long-term mortality, which means it may be a useful means to identify high-risk patients. (Arq Bras Cardiol. 2021; 116(2):248-256) 相似文献
83.
84.
Borlandelli Elena Ciaffi Jacopo Festuccia Gianluca Facchini Giancarlo Miceli Marco Brusi Veronica Mancarella Luana Lisi Lucia Di Martino Alberto Faldini Cesare Meliconi Riccardo Ursini Francesco 《Clinical rheumatology》2022,41(2):483-490
Clinical Rheumatology - Osteitis condensans ilii (OCI) is a benign condition characterised by triangular sclerosis of the iliac bone which may mimic radiographic sacroiliitis. Prevalence is... 相似文献
85.
Pandey Arjun K. Xu Ke Zhang Li Gupta Saurabh Eikelboom John Lopes Renato D. Crowther Mark Belley-Côté Emilie P. Whitlock Richard P. 《Journal of thrombosis and thrombolysis》2022,53(3):697-707
Journal of Thrombosis and Thrombolysis - The optimal INR target in patients with mechanical heart valves is unclear. Higher INR targets are often used in Western compared with East Asian countries.... 相似文献
86.
87.
88.
Nuzzo F Morabito A De Maio E Di Rella F Gravina A Labonia V Landi G Pacilio C Piccirillo MC Rossi E D'Aiuto G Thomas R Gori S Colozza M De Placido S Lauria R Signoriello G Gallo C Perrone F de Matteis A 《Critical reviews in oncology/hematology》2008,66(2):171-180
Within an ongoing multicentre phase 3 randomised trial (ELDA, cancertrials.gov ID: NCT00331097), early breast cancer patients, 65-79 years old, with average to high risk of recurrence, are randomly assigned to receive CMF (cyclophosphamide 600 mg/m2, methotrexate 40 mg/m2, fluorouracil 600 mg/m2, days 1-8) or docetaxel (35 mg/m2 days 1-8-15), every 4 weeks. Here we report an unplanned safety analysis prompted by an amendment introducing creatinine clearance as a tool to adjust methotrexate dose. Before such change, 101 patients with a median age of 70 were randomly assigned CMF (53 patients) or docetaxel (48 patients). At least one grades 3-4 toxic event of any type was reported in 40 (75.5%) and 19 (39.6%) patients with CMF and docetaxel, respectively (p=0.0002). Grades 3-4 hematological events were observed in 37 (69.8%) vs. 4 (8.3%) cases (p<0.0001) and grades 3-4 non-hematological toxicity in 12 (22.6%) vs. 15 (31.2%) patients (p=0.11), with CMF and docetaxel, respectively. A higher incidence of anemia, neutropenia, thrombocytopenia and febrile neutropenia was reported with CMF. Constipation, mucositis, nausea and vomiting were more common with CMF; diarrhoea, abdominal pain, dysgeusia, neuropathy and liver toxicity were more frequent with docetaxel. No significant interaction was found between the occurrence of severe toxicity and baseline variables, including creatinine clearance and geriatric activity scales. In conclusion, weekly docetaxel appears to be less toxic than CMF in terms of hematological toxicity. 相似文献
89.
Russo D Malagola M de Vivo A Fiacchini M Martinelli G Piccaluga PP Damiani D Candoni A Michielutti A Castelli M Testoni N Ottaviani E Rondoni M Pricolo G Mazza P Zuffa E Zaccaria A Raspadori D Bocchia M Lauria F Bonini A Avanzini P Gugliotta L Visani G Fanin R Baccarani M 《British journal of haematology》2005,131(2):172-179
Fludarabine plus cytarabine (Ara-C) and idarubicin (FLAI) is an effective and well-tolerated induction regimen for the treatment of acute myeloid leukaemia (AML). This phase III trial compared the efficacy and toxicity of FLAI versus idarubicin plus Ara-C and etoposide (ICE) in 112 newly diagnosed AML patients <60 years. Fifty-seven patients received FLAI, as the first induction-remission course, and 55 patients received ICE. Post-induction treatment consisted of high-dose Ara-C (HDAC). After HDAC, patients in complete remission (CR) received a second consolidation course (mitoxantrone, etoposide, Ara-C) and autologous stem cell transplantation (auto-SCT) or allogeneic (allo)-SCT, according to the age, disease risk and donor availability. After a single induction course, CR rate was 74% in the FLAI arm and 51% in the ICE arm (P = 0.01), while death during induction was 2% and 9% respectively. Both haematological (P = 0.002) and non-haematological (P = 0.0001) toxicities, especially gastrointestinal (i.e. nausea, vomiting, mucositis and diarrhoea), were significantly lower in FLAI arm. In both arms, relapses were more frequent in patients who were not submitted to allo-SCT. After a median follow-up of 17 months, 30% and 38% of the patients are in continuous CR in FLAI and ICE arm respectively. Our prospective randomised study confirmed the anti-leukaemic effect and the low toxic profile of FLAI as induction treatment for newly diagnosed AML patients. 相似文献
90.
PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas 总被引:4,自引:0,他引:4