全文获取类型
收费全文 | 5858篇 |
免费 | 321篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 114篇 |
妇产科学 | 202篇 |
基础医学 | 753篇 |
口腔科学 | 443篇 |
临床医学 | 325篇 |
内科学 | 1507篇 |
皮肤病学 | 93篇 |
神经病学 | 428篇 |
特种医学 | 178篇 |
外科学 | 864篇 |
综合类 | 20篇 |
一般理论 | 1篇 |
预防医学 | 255篇 |
眼科学 | 126篇 |
药学 | 274篇 |
中国医学 | 18篇 |
肿瘤学 | 538篇 |
出版年
2023年 | 32篇 |
2022年 | 51篇 |
2021年 | 166篇 |
2020年 | 94篇 |
2019年 | 143篇 |
2018年 | 162篇 |
2017年 | 121篇 |
2016年 | 149篇 |
2015年 | 141篇 |
2014年 | 233篇 |
2013年 | 293篇 |
2012年 | 513篇 |
2011年 | 496篇 |
2010年 | 280篇 |
2009年 | 241篇 |
2008年 | 414篇 |
2007年 | 389篇 |
2006年 | 356篇 |
2005年 | 344篇 |
2004年 | 331篇 |
2003年 | 283篇 |
2002年 | 264篇 |
2001年 | 47篇 |
2000年 | 30篇 |
1999年 | 39篇 |
1998年 | 50篇 |
1997年 | 48篇 |
1996年 | 43篇 |
1995年 | 34篇 |
1994年 | 39篇 |
1993年 | 25篇 |
1992年 | 22篇 |
1991年 | 23篇 |
1990年 | 17篇 |
1989年 | 19篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 22篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 13篇 |
1982年 | 23篇 |
1981年 | 15篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1976年 | 9篇 |
1974年 | 9篇 |
1973年 | 10篇 |
1972年 | 9篇 |
1970年 | 8篇 |
排序方式: 共有6196条查询结果,搜索用时 31 毫秒
991.
Gonçalves DA Silva EV Graça FA Lira EC Zanon NM Mendes GE Burdmann EA Migliorini RH Kettelhut IC Navegantes LC 《The American journal of tropical medicine and hygiene》2008,79(5):771-778
This study investigated the in vivo effects of the Bothrops jararaca venom (BjV) on general metabolic profile and, specifically, on muscle protein metabolism in rats. The crude venom (0.4 mg/kg body weight, IV) was infused in awake rats, and plasma activity of enzymes and metabolites levels were determined after 1, 2, 3, and 4 hours. BjV increased urea, lactate, and activities of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase after 4 hours. The content of liver glycogen was reduced by BjV. Protein metabolism was evaluated by means of microdialysis technique and in isolated muscles. BjV induced increase in the muscle interstitial-arterial tyrosine concentration difference, indicating a high protein catabolism. The myotoxicity induced by this venom is associated with reduction of protein synthesis and increase in rates of overall proteolysis, which was accompanied by activation of lysosomal and ubiquitin-proteasome systems without changes in protein levels of cathepsins and ubiquitin-protein conjugates. 相似文献
992.
993.
Costa SR Horta SH Miotto MJ Costas MC Godinho CA Henriques AC 《Arquivos de gastroenterologia》2008,45(1):73-81
BACKGROUND: Despite its rarity, gallbladder cancer is an aggressive type of neoplasia with a very poor prognosis. The best resection for oncological purposes continues to be right hepatectomy extended to segment IV. However, bisegmentectomy IV-V is becoming an interesting alternative because of greater preservation of the parenchyma. AIM: To report the early and late results from bisegmentectomy IV-V in cases of carcinoma of the gallbladder. METHODS: A series of seven cases of invasive carcinoma is presented (six women and one man). These patients underwent bisegmentectomy IV-V at the General Surgery Service of the Teaching Hospital of the ABC Medical School, Santo André, SP, Brazil. The study was conducted between 2002 and 2006. The patients ages ranged from 52 to 72 years. The diagnosis was preoperative (radiological) in five cases, which were all confirmed by intraoperative frozen-tissue examination, while in two cases the diagnosis was postoperative, following open cholecystectomy. RESULTS: The duration of the operation ranged from 180 to 340 minutes. The quantity of intraoperative bleeding ranged from 200 to 1500 mL. There were two major complications but no mortality. Six patients did not present any recurrence over the course of 3 to 30 months of follow-up. CONCLUSION: Bisegmentectomy IV-V may constitute a curative surgical alternative for treating gallbladder cancer. This procedure presents acceptable morbidity and mortality. 相似文献
994.
995.
996.
997.
998.
Redublo Quinto BM Camargo de Andrade MC Ronchi FA Santos EL Alves Correa SA Shimuta SI Pesquero JB Mortara RA Casarini DE 《International immunopharmacology》2008,8(2):254-260
We described in mouse inner medullary-collecting duct cells (mIMCD-3) the somatic and the N-domain ACE synthesis and its interaction with the kallikrein-kinin system co-localized in the same cells. We purified two ACE forms from culture medium, M1 (130 kDa) and M2 (N-domain, 60 kDa), and cellular lysate, C1 (130 kDa) and C2 (N-domain, 60 kDa). Captopril and enalaprilat inhibited the purified enzymes. The immunofluorescence studies indicated that ACE is present in the membrane, cytoplasm and in the cell nucleus. Kinin B1 and B2 receptors were detected by immunofluorescence and showed to be activated by BK and DesR9 BK, increasing the acidification rate which was enhanced in the presence of enalaprilat. The presence of secreted and intracellular ACE in mIMCD-3 confirmed the hypothesis previously proposed by our group for a new site of ACE secretion in the collecting duct. 相似文献
999.
Crohn's disease and ulcerative colitis represent the most common forms of inflammatory bowel disease (IBD), clinical conditions affecting the small and/or large bowel. It is well known that IBD is an immune-mediated condition and that TNF-alpha plays a pivotal role in the pathogenesis of the disease. TNF-alpha has been scrupulously studied as a target for therapeutic intervention in this setting. A number of biologic compounds have been developed, including the European Medicine Agency (EMEA)-approved agents, infliximab and adalimumab. Although their efficacy in induction and maintenance of remission has been established by several clinical trials, many issues regarding safety remain to be elucidated. In fact, anti-TNF treatment may be associated with a number of rare, but serious, adverse events, including infusion reactions, infections, lymphomas and other malignancies. A black-box warning has to be taken into consideration when looking at potential serious infections such as tuberculosis. Active infections, demyelinating disorders and severe heart failure are contraindications for anti-TNF treatment. This review focuses on drug toxicity and adverse events related to infliximab treatment in IBD. 相似文献
1000.
Pierleone Lucatelli Beatrice Sacconi Fabrizio Cereatti Renato Argirò Mario Corona Mario Bezzi Fabrizio Fanelli Fausto Fiocca Luca Saba Carlo Catalano 《Cardiovascular and interventional radiology》2016,39(9):1327-1331
Postoperative pancreatic fistula (POPF) with leakage of pancreatic juice is a rare, severe complication following pancreatic resection or, less commonly, splenectomy. Definitive treatment can require multidisciplinary approaches. We report a case of stenosis of the main pancreatic duct with distal tail GRADE C POPF, occurred after splenectomy for Hodgkin lymphoma, successfully treated with combined radiological-endoscopic approach. 相似文献