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141.
Cintra Luciano Tavares Angelo Gomes Maximiliano Schünke da Silva Cristiane Cantiga Faria Flávio Duarte Benetti Francine Cosme-Silva Leopoldo Samuel Renata Oliveira Pinheiro Tiago Novaes Estrela Carlos González Alvaro Cruz Segura-Egea Juan José 《Odontology / the Society of the Nippon Dental University》2021,109(4):741-769
Odontology - Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to... 相似文献
142.
Paola Monti Debora Russo Renata Bocciardi Giorgia Foggetti Paola Menichini Maria T. Divizia Margherita Lerone Claudio Graziano Anita Wischmeijer Hector Viadiu Roberto Ravazzolo Alberto Inga Gilberto Fronza 《Human mutation》2013,34(6):894-904
TP63 germ‐line mutations are responsible for a group of human ectodermal dysplasia syndromes, underlining the key role of P63 in the development of ectoderm‐derived tissues. Here, we report the identification of two TP63 alleles, G134V (p.Gly173Val) and insR155 (p.Thr193_Tyr194insArg), associated to ADULT and EEC syndromes, respectively. These alleles, along with previously identified G134D (p.Gly173Asp) and R204W (p.Arg243Trp), were functionally characterized in yeast, studied in a mammalian cell line and modeled based on the crystal structure of the P63 DNA‐binding domain. Although the p.Arg243Trp mutant showed both complete loss of transactivation function and ability to interfere over wild‐type P63, the impact of p.Gly173Asp, p.Gly173Val, and p.Thr193_Tyr194insArg varied depending on the response element (RE) tested. Interestingly, p.Gly173Asp and p.Gly173Val mutants were characterized by a severe defect in transactivation along with interfering ability on two DN‐P63α‐specific REs derived from genes closely related to the clinical manifestations of the TP63‐associated syndromes, namely PERP and COL18A1. The modeling of the mutations supported the distinct functional effect of each mutant. The present results highlight the importance of integrating different functional endpoints that take in account the features of P63 proteins' target sequences to examine the impact of TP63 mutations and the associated clinical variability. 相似文献
143.
Beata Bobrowska Wojciech Zasada Andrzej Surdacki Tomasz Rakowski Pawe? Kleczyński Jolanta ?wierszcz Olga Kruszelnicka Renata Rajtar-Salwa Saleh Arif Danuta Sorysz Dariusz Dudek Jacek S. Dubiel 《International journal of medical sciences》2013,10(10):1361-1366
Background. Patients with degenerative aortic stenosis (AS) exhibit elevated prevalence of coronary artery disease (CAD) and internal carotid artery stenosis (ICAS). Our aim was to investigate prevalence of significant CAD and ICAS in relation to demographic and cardiovascular risk profile among patients with severe degenerative AS.Methods. We studied 145 consecutive patients (77 men and 68 women) aged 49-91 years (median, 76) with severe degenerative AS who underwent coronary angiography and carotid ultrasonography in our tertiary care center. The patients were divided into two groups according to the presence of either significant CAD (n=86) or ICAS (n=22).Results. The prevalence of significant CAD or ICAS was higher with increasing number of traditional risk factors (hypertension, hypercholesterolemia, diabetes, smoking habit) and decreasing renal function. We found interactions between age and gender in terms of CAD (p=0.01) and ICAS (p=0.06), which was confirmed by multivariate approach. With the reference to men with a below-median age, the prevalence of CAD or ICAS increased in men aged >76 years (89% vs. 55% and 28% vs. 14%, respectively), whereas the respective percentages were lower in older vs. younger women (48% vs. 54% and 7% vs. 17%).Conclusions. In severe degenerative AS gender modulates the association of age with coronary and carotid atherosclerosis with its lower prevalence in women aged >76 years compared to their younger counterparts. This may result from a hypothetical “survival bias”, i.e., an excessive risk of death in very elderly women with severe AS and coexisting relevant coronary or carotid atherosclerosis. 相似文献
144.
Alessandro Schwertner Renato Rodrigues de Almeida Renata Rodrigues de Almeida-Pedrin Thais Maria Freire Fernandes Paula Oltramari Marcio Rodrigues de Almeida 《The Angle orthodontist》2020,90(4):500
ObjectiveTo assess and compare the effects produced in the maxillary dental arch by means of Connecticut intrusion arch (CIA) with or without a cinch back on the distal end of the tube of the first molars.Materials and MethodsThis study included 44 patients with a mean age of 13.1 ± 1.8 years treated for deep bite with a CIA randomly divided into two groups: group 1 (G1), 22 patients with initial mean age of 12.72 ± 1.74 years treated with the CIA in the upper arch without a cinch back on the distal surface of the tube of the first molars, and group 2 (G2), 22 patients with an initial mean age of 13.67 ± 2.03 years treated with the CIA with a cinch back. Lateral cephalograms were available before treatment (T1) and after intrusion of maxillary incisors (T2). The mean treatment period was 5.5 ± 1.45 months. Intragroup and intergroup changes in the maxillary incisor and molar positions were analyzed by paired and independent t-tests associated with the Holm-Bonferroni correction method for multiple comparisons (P < .05).ResultsThere were significant differences between groups in terms of maxillary incisor displacement. The maxillary incisors flared labially (2.17°) and proclined (1.68 mm) in group 1, whereas a palatal inclination (−1.99°) and retroclination (−1.13 mm) was observed in group 2. No significant differences were found for the molar positions between the groups.ConclusionsThe presence or absence of a distal bend in CIA affects incisor tipping and proclination during intrusion mechanics. 相似文献
145.
146.
Renata Nunes Cabral Bente Nyvad Vera Ligia Vieira Mendes Soviero Eduardo Freitas Soraya Coelho Leal 《Clinical oral investigations》2020,24(2):727-734
To describe a new molar-incisor hypomineralization (MIH) severity scoring system (MIH-SSS) that focuses on the defects’ severity and to assess the sy 相似文献
147.
Rodrigues Renata Prata Cunha Bernardes de Andrade Vieira Walbert Siqueira Walter Luiz Blumenberg Cauane de Macedo Bernardino talo Cardoso Srgio Vitorino Flores-Mir Carlos Paranhos Luiz Renato 《Clinical oral investigations》2020,24(7):2203-2217
Clinical Oral Investigations - To assess whether salivary urea and creatinine levels accurately reflect their serum levels in blood samples of adults to detect chronic kidney disease. A systematic... 相似文献
148.
149.
150.
Maritza Del Carmen Quezada‐Conde Patricia de Lourdes Alvarez‐Velasco Edisson Fernando Lopez Marco Vinicio Medina Renata Pereira de Samuel Marques Marcia Turolla Wanderley E. Michel-Crosato Claudio Mendes Pannuti Antonio Carlos Frias Daniela Prcida Raggio Fausto Medeiros Mendes 《Dental traumatology》2020,36(5):510-517