全文获取类型
收费全文 | 175390篇 |
免费 | 10066篇 |
国内免费 | 458篇 |
专业分类
耳鼻咽喉 | 2317篇 |
儿科学 | 5681篇 |
妇产科学 | 3696篇 |
基础医学 | 23863篇 |
口腔科学 | 7876篇 |
临床医学 | 12830篇 |
内科学 | 39172篇 |
皮肤病学 | 4446篇 |
神经病学 | 14627篇 |
特种医学 | 5431篇 |
外国民族医学 | 26篇 |
外科学 | 21443篇 |
综合类 | 1411篇 |
现状与发展 | 1篇 |
一般理论 | 63篇 |
预防医学 | 18229篇 |
眼科学 | 3315篇 |
药学 | 10662篇 |
中国医学 | 703篇 |
肿瘤学 | 10122篇 |
出版年
2023年 | 921篇 |
2022年 | 2041篇 |
2021年 | 3811篇 |
2020年 | 2550篇 |
2019年 | 3566篇 |
2018年 | 4988篇 |
2017年 | 3724篇 |
2016年 | 3510篇 |
2015年 | 4114篇 |
2014年 | 5603篇 |
2013年 | 7101篇 |
2012年 | 11009篇 |
2011年 | 11561篇 |
2010年 | 5862篇 |
2009年 | 5260篇 |
2008年 | 8909篇 |
2007年 | 9556篇 |
2006年 | 8849篇 |
2005年 | 9120篇 |
2004年 | 8563篇 |
2003年 | 7768篇 |
2002年 | 5805篇 |
2001年 | 4976篇 |
2000年 | 4966篇 |
1999年 | 4383篇 |
1998年 | 1569篇 |
1997年 | 1309篇 |
1996年 | 1296篇 |
1995年 | 1103篇 |
1994年 | 1087篇 |
1993年 | 1000篇 |
1992年 | 2669篇 |
1991年 | 2595篇 |
1990年 | 2355篇 |
1989年 | 2357篇 |
1988年 | 2130篇 |
1987年 | 1969篇 |
1986年 | 1834篇 |
1985年 | 1766篇 |
1984年 | 1264篇 |
1983年 | 1021篇 |
1982年 | 576篇 |
1981年 | 519篇 |
1980年 | 499篇 |
1979年 | 927篇 |
1978年 | 609篇 |
1977年 | 483篇 |
1975年 | 550篇 |
1974年 | 542篇 |
1973年 | 542篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
Chronic intestinal pseudo-obstruction: manifestations, natural history and management 总被引:2,自引:0,他引:2
v. stanghellini r. f. cogliandro r. de giorgio g. barbara b. salvioli & r. corinaldesi 《Neurogastroenterology and motility》2007,19(6):440-452
Chronic intestinal pseudo-obstruction (CIPO) is a rare pathological condition characterized by a marked derangement of gut propulsive motility mimicking mechanical obstruction, in the absence of any lesion occluding the gut lumen. This disease is often associated with a disabling and potentially life-threatening complications and is still too often unrecognized even in referral centres. As a result, patients receive neither appropriate care nor recognition of their severe health condition. Medical and surgical therapies are often unsatisfactory and long-term outcome turns out to be poor in the vast majority of cases. This article focuses on the main clinical features, the management and long-term outcome of patients affected by CIPO, with particular emphasis on those aspects which remain a matter of debate. 相似文献
72.
73.
J J de Souza T Perlmann A A Herman O J Ransome R W Kantor 《Suid-Afrikaanse tydskrif vir geneeskunde》1987,71(11):690-692
The value of maternal C-reactive protein (CRP) levels as predictors of fetal and maternal infective morbidity and fetal mortality was assessed prospectively over a 6-month period in all cases of premature rupture of the fetal membranes or suspected premature labour. Statistical analysis of results showed that CRP at a level of 1.32 mg/dl is a sensitive marker of infective morbidity in mother and neonate. Furthermore, there was a significant association between raised CRP levels and low-birth-weight babies, suggesting that intra-uterine infection is a major cause of prematurity in the study population. 相似文献
74.
75.
76.
Alcides José Branco Filho William Kondo Luis Sérgio Nassif Mariana Jorge Garcia Rafael de Almeida Tirapelle Carlos Marcelo Dotti 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2006,10(3):326-331
BACKGROUND: Gastrogastric fistula is a communication between the proximal gastric pouch and the distal gastric remnant, rarely described in the realm of bariatric procedures. The aim of this study was to review the existing literature about this topic and to demonstrate its laparoscopic treatment. METHODS: An extensive literature review found several articles reporting this complication. However, no citation was found describing the steps of the laparoscopic management of this situation. RESULTS: Gastrogastric fistula occurs in up to 6% of Roux-en-Y gastric bypasses. Two theories exist for fistula formation: (1) it is a technical complication derived from the incomplete division of the stomach during the creation of the pouch, and (2) it occurs after a staple-line failure, developing a leak with an abscess, which then drains into the distal stomach forming the fistula. Early symptoms include fever, tachycardia, and abdominal pain. Failure in weight loss is a late clinical sign observed in these patients. Diagnosis is based on radiologic study, upper endoscopy and computed tomography. When identified in the acute postoperative course, laparoscopic treatment is easy. Chronic fistulas are difficult to manage, and the laparoscopic approach is an alternative to open surgery. CONCLUSIONS: Gastrogastric fistula is a possible complication of Roux-en-Y gastric bypass and its laparoscopic treatment is feasible. 相似文献
77.
78.
Y. Le Meur M. Büchler A. Thierry S. Caillard F. Villemain S. Lavaud I. Etienne P.-F. Westeel B. H. de Ligny L. Rostaing E. Thervet J. C. Szelag J.-P. Rérolle A. Rousseau G. Touchard P. Marquet 《American journal of transplantation》2007,7(11):2496-2503
Efficacy and safety of mycophenolate mofetil (MMF) may be optimized with individualized doses based on therapeutic monitoring of its active metabolite, mycophenolic acid (MPA). In this 12-month study, 137 renal allograft recipients from 11 French centers receiving basiliximab, cyclosporine A, MMF and corticosteroids were randomized to receive either concentration-controlled doses or fixed-dose MMF. A novel Bayesian estimator of MPA AUC based on three-point sampling was used to individualize doses on posttransplant days 7 and 14 and months 1, 3 and 6. The primary endpoint was treatment failure (death, graft loss, acute rejection and MMF discontinuation). Data from 65 patients/group were analyzed. At month 12, the concentration-controlled group had fewer treatment failures (p = 0.03) and acute rejection episodes (p = 0.01) with no differences in adverse event frequency. The MMF dose was higher in the concentration-controlled group at day 14 (p < 0.0001), month 1 (p < 0.0001) and month 3 (p < 0.01), as were median AUCs on day 14 (33.7 vs. 27.1 mg*h/L; p = 0.0001) and at month 1 (45.0 vs. 30.9 mg*h/L; p < 0.0001). Therapeutic MPA monitoring using a limited sampling strategy can reduce the risk of treatment failure and acute rejection in renal allograft recipients 12 months posttransplant with no increase in adverse events. 相似文献
79.
Jan de Lange Thomas Putters Erik M Baas Johan M van Ingen 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):841-845
OBJECTIVE: The purpose of this study was to evaluate the potential benefit of an ultrasonic device in apical surgery on the outcome of treatment. STUDY DESIGN: A randomized prospective design was used in a standardized treatment protocol. Patients were allocated to treatment with an ultrasonic device (P-Max Newtron) or treatment with a bur in an otherwise similar protocol. One year after treatment the results were evaluated by 2 oral and maxillofacial surgeons who were blinded for the therapy. RESULTS: Out of a total group of 399 patients who were included in the study, adequate follow-up could be obtained in 290 patients. The overall success rate in the ultrasonic group was 80.5% and in the group treated with a bur 70.9% (P = .056). In molars, the difference in success rate was significant (P = .02). CONCLUSION: The use of an ultrasonic device in apical surgery improved the outcome of treatment. In molars this effect was significant. 相似文献
80.
E S C Korf E C W van Straaten F-E de Leeuw W M van der Flier F Barkhof L Pantoni A M Basile D Inzitari T Erkinjuntti L-O Wahlund E Rostrup R Schmidt F Fazekas P Scheltens 《Diabetic medicine》2007,24(2):166-171
HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH. 相似文献