全文获取类型
收费全文 | 879篇 |
免费 | 42篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 18篇 |
妇产科学 | 26篇 |
基础医学 | 27篇 |
口腔科学 | 2篇 |
临床医学 | 52篇 |
内科学 | 272篇 |
皮肤病学 | 7篇 |
神经病学 | 20篇 |
特种医学 | 12篇 |
外科学 | 348篇 |
综合类 | 9篇 |
预防医学 | 5篇 |
眼科学 | 53篇 |
药学 | 16篇 |
肿瘤学 | 37篇 |
出版年
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 16篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 14篇 |
2017年 | 17篇 |
2016年 | 26篇 |
2015年 | 29篇 |
2014年 | 48篇 |
2013年 | 45篇 |
2012年 | 67篇 |
2011年 | 60篇 |
2010年 | 42篇 |
2009年 | 37篇 |
2008年 | 47篇 |
2007年 | 64篇 |
2006年 | 71篇 |
2005年 | 68篇 |
2004年 | 66篇 |
2003年 | 71篇 |
2002年 | 34篇 |
2001年 | 20篇 |
2000年 | 10篇 |
1999年 | 5篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 6篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 5篇 |
1985年 | 1篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1973年 | 3篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有925条查询结果,搜索用时 15 毫秒
61.
The issue of performing tissue sampling from the vesicourethral anastomotic area postradical prostatectomy (transrectal ultrasound-guided biopsy) after radical surgical treatment of local disease has failed, still remains controversial. We review a selection of articles that evaluate this procedure as well as newer diagnostic modalities and we discuss how this technique may have a position in our treatment dilemmas in cases with biochemical failure of undetermined origin. 相似文献
62.
Ozdemir H Altin R Mahmutyazicioğlu K Kart L Uzun L Savranlar A Davçanci H Gündoğdu S 《Archives of otolaryngology--head & neck surgery》2004,130(9):1052-1055
OBJECTIVE: To evaluate by computed tomographic scanning the paranasal mucosal changes of coal workers with and without pneumoconiosis. METHODS: Examination of images and scores from paranasal computed tomographic scans. The study participants were 26 coal workers with pneumoconiosis, 29 coal workers without pneumoconiosis, and 20 controls. All were men. The extent and patterns of inflammatory paranasal sinus disease were evaluated on computed tomographic scans by 2 radiologists using the terminology and definitions of Newman and associates. RESULTS: Interobserver agreement for the presence of abnormalities was from good to excellent (kappa, 0.63-0.89). The mucosal scores of individuals and groups were higher for coal workers than for control subjects. Both scores were significantly higher in the pneumoconiosis group than in the 2 other groups. CONCLUSIONS: This study shows that paranasal sinuses were affected more severely in coal workers than in control subjects. In coal workers with pneumoconiosis, the affection was most severe. The relationship between coal dust exposure and paranasal mucosal changes needs further study. 相似文献
63.
When to biopsy and when to stop biopsying 总被引:2,自引:0,他引:2
With the widespread use of serum prostate-specific antigen (PSA) and transrectal ultrasound-guided needle biopsy of the prostate in men with suspected prostate cancer, physicians are faced with the dilemma of treating a patient with a high index of suspicion of prostate cancer but with an initial set of negative biopsies. For the initial biopsy, the optimal number of biopsy cores for detecting prostate cancer in prostate biopsy remains controversial; it is also often unclear who should undergo a repeat prostatebiopsy and when to stop biopsying. 相似文献
64.
In hips with acetabular dysplasia, we performed Kotz osteotomy (group 1) in 22 hips (20 patients; mean age 24.3 years) and Ganz osteotomy (group 2) in 23 hips (22 patients; mean age 23.1 years). Group 1 was followed 83.3 (56-112) months and group 2 40.9 (24-66) months. In group 1, Harris hip score improved from average 74.9 to 86.9, mean center edge (CE) angle from -4.5 degrees to 30.3 degrees, and mean vertical center edge (VCE) angle from 5.3 degrees to 36.2 degrees. In group 2, Harris hip score improved from average 76.6 to 91.1, mean CE angle from -5.9 degrees to 32.0 degrees, and mean VCE angle from 5.0 degrees to 41.3 degrees. Using Pauwels criteria, regression was observed in 12 hips in group 1 and one progressed. In group 2, 15 hips showed regression and three progressed. In patients treated with Ganz osteotomy, the complication rate was higher and the complications more serious than in patients treated with Kotz osteotomy. Most complications were, however, seen among the first ten patients treated with Ganz osteotomy. Although we detected no significant difference between the two groups in terms of clinical and radiological findings, we believe the outcome to be slightly better after a properly performed Ganz osteotomy. 相似文献
65.
66.
The relation between tooth loss and bone mass in postmenopausal osteoporotic women in Turkey: a multicenter study 总被引:3,自引:0,他引:3
Gur A Nas K Kayhan O Atay MB Akyuz G Sindal D Akşit R Oncel S Dilsen G Cevik R Gunduz OH Ersoy Y Altay Z Ozturk C Akkus S Senocak O Kavuncu V Kirnap M Tekeoglu I Erdogan F Sarac AJ Demiralp L Demirkesen A Adam M 《Journal of bone and mineral metabolism》2003,21(1):43-47
The purpose of this study was to investigate the associations of tooth loss with skeletal bone mass, years since menopause,
educational level, current smoking status, dietary calcium intake, and number of pregnancies in postmenopausal osteoporotic
women in Turkey. The study population consisted of 1171 postmenopausal women aged 40–86 years (mean age, 61.19 ± 7.28 years).
A detailed history was obtained from all women, including relevant lifestyle parameters, risk factors, and measurements of
weight and height. Women were separated into three groups according to the number of teeth remaining as group 1 (edentulous,
457 women), group 2 (10 or fewer teeth, 232 women), and group 3 (more than 10 teeth remaining, 482 women). There was no significant
difference among the three groups in mean age and menopausal age (P < 0.05). Body mass index of group 1 was significantly higher than that of group 2 (P < 0.01). Educational level was significantly different between three groups: groups 1 and 2 (P < 0.001), groups 1 and 3 (P < 0.0001), and groups 2 and 3 (P < 0.001). Educational level was lowest in group 1 and highest in group 3. Despite a low ratio of cigarette smoking in general,
a smoking habit was most prevalent in group 3 and least in group 2. The ratio of women receiving adequate calcium was significantly
lower in group 1 than in other groups (P < 0.001); mean calcium intake was similar in all groups. The number of pregnancies was significantly higher in group 1 than
in other groups (P < 0.001). Lumbar bone mineral density (BMD) of group 1 was significantly lower than that of groups 2 and 3 (P < 0.001). Although no significant difference was found between groups 1 and 3, femoral neck BMD of group 2 was less than in
others, and differences between groups 1 and 2 and between groups 2 and 3 (P < 0.001) were significant. Lumbar bone mineral content (BMC) of group 1 was significantly lower than that of groups 2 and
3 (P < 0.001), and lumbar BMC in group 2 was significantly higher than in group 3 (P < 0.05). Femoral neck BMC in group 1 was significantly higher than in groups 2 and 3 (P < 0.001). In conclusion, lumbar BMD and BMC in the edentulous group were significantly lower, whereas femoral neck BMD and
BMC were significantly higher in edentulous group compared with the others. Our findings indicated that improvement in lifestyle
factors and nutritional strategies for the treatment and prevention of osteoporosis may have additional benefit in reducing
tooth loss.
Received: February 18, 2002 / Accepted: June 21, 2002
Offprint requests to: A. Gur 相似文献
67.
Influence of number of pregnancies on bone mineral density in postmenopausal women of different age groups 总被引:7,自引:0,他引:7
Gur A Nas K Cevik R Sarac AJ Ataoglu S Karakoc M 《Journal of bone and mineral metabolism》2003,21(4):234-241
As data on the relationship between parity and bone mineral density often seem to be controversial, ultimately, a comprehensive
research study was thought to be necessary. This study focused on examining the influence of the number of pregnancies on
bone mineral density and investigating the relationship between pregnancy and bone mineral density at four sites in postmenopausal
women of different age groups. A total of 509 postmenopausal women, varying from 45 to 86 years of age (mean age of 60.85
± 7.53 years) were considered for the study. A standardized interview was employed to obtain information on demographics,
lifestyle, and, reproductive and menstrual histories. Patients were separated into four groups according to the number of
pregnancies, i.e., nulliparae (52 patients), one to two parity (66 patients), three to five parity (178 patients), and more
than five parity (213 patients). The patients were further classified into two age groups, 40–59 years (233 patients) and
60–80 years (276 patients), respectively. The number of pregnancies was found to range from 0 to 17 (with an overall mean
of 5.42 ± 3.68), with 4.29 ± 2.74 (range, 0–16) accounting for live births, while 1.02 ± 1.53 (range, 0–14) were abortions.
There were no significant differences among the groups with respect to parameters such as, age, body mass index (BMI), age
at menarche, age at menopause, and years since menopause (P > 0.05) in all of the 509 women and in the 40- to 59- and 60- to 80-year groups. When all the patients were considered, the
bone mineral density (BMD) values of the spine and the trochanter for the more-than-five-parity group, were found to be significantly
lower than those of the other groups (P < 0.05), while the BMD values of the spine and the femur (neck, trochanter) appeared to decrease with increasing parity.
In the 40- to 59-year group, the BMD of the spine in both the nulliparae and one-to-two-parity groups was significantly higher
than that of the more-than-five-parity group (P < 0.05). No significant differences were found among the groups with respect to the BMD values at any femur sites. The nulliparae
patients in the 60- to 80-year group exhibited significantly higher trochanter and Ward's BMD values than those of the more-than-five-parity
group (P < 0.05), whereas in the one-to-two-parity group, spine BMD values appeared to be significantly higher than those of the more-than-five-parity
group (p < 0.05). Significant correlations were found between the number of pregnancies and BMD values for the spine (r = −0.23; P < 0.01), trochanter (r = −0.16; P < 0.01), and Ward's triangle (r = −0.14; P < 0.05), with no significant correlation for femur neck BMD (r = −0.08; P > 0.05) values. In conclusion, the present study suggests that the number of pregnancies has an effect on the BMD values
and that this situation shows a variation in different age groups. In addition, our study indicates that there is a significant
correlation between the number of pregnancies and the spine, trochanter, and Ward's triangle BMD, but there is no correlation
for the femur neck BMD.
Received: April 30, 2002 / Accepted: January 16, 2003
RID="*"
ID="*" Offprint requests to: A. Gur 相似文献
68.
Rectal Advancement Flap Repair of Rectourethral Fistula 总被引:2,自引:2,他引:0
Garofalo TE Delaney CP Jones SM Remzi FH Fazio VW 《Diseases of the colon and rectum》2003,46(6):762-769
PURPOSE: Several procedures have been described for the management of rectourethral fistula. There has been no consensus on the best method of repair. The aim of this study was to review our experience with treatment of rectourethral fistula, focusing on the outcomes of rectal advancement flap repair. METHODS: Data collected included demographics, cause, procedure type, presentation, operative details, and morbidity. Telephone follow-up was conducted to evaluate functional outcome and quality of life. RESULTS: From 1981 to 2001, 23 male patients (age, 54 +/- 15 years) were treated for rectourethral fistula. Fecal diversion alone was performed in seven patients (30 percent), and urinary diversion alone was performed in one patient (4 percent). Both fecal and urinary diversion were performed in 12 patients (52 percent), and no diversion was performed in 3 (13 percent). Four patients were managed conservatively with diversion only. Nineteen patients underwent definitive repair. Rectal advancement flap repair was used in 12 (52 percent) of the cases. Postoperative length of stay was 4.5 +/- 4 days. Patients were followed up for an average of 31 +/- 33.4 months. Rectal advancement flap achieved primary closure in 8 (67 percent) of 12 patients. There were four recurrences. Two patients underwent successful repeat repair, for a final success rate of 83 percent. Morbidity associated with rectal advancement flap was 8 percent (1/12 patients). Cleveland Global Quality of Life score averaged 0.82 +/- 0.13. CONCLUSION: The rectal advancement flap provides an effective repair for rectourethral fistula. Successful repair can be achieved in a majority of patients with minimal morbidity, short length of stay, and a good postoperative quality of life. 相似文献
69.
Background: Metabolic syndrome includes abdominal obesity, diabetes type 2, hypertension, dyslipidemia, derangements of fibrinolysis,
and atherosclerosis. Since abdominal obesity is one of the major components of the insulin resistance syndrome (IRS), an attempt
was made to evaluate the interrelationships between the magnitude of obesity and the components of the syndrome. Methods:
A cross-sectional study of 123 subjects with type 2 diabetes, of whom 31 were normal body weight and 92 had varying degrees
of obesity was conducted. The participants were investigated in terms of clinical and laboratory findings of IRS. Fasting
and 30-min (early) plasma glucose and serum insulin excursions in response to oral glucose challenge (75 g) were determined.
The peripheral and hepatic insulin resistance (insensitivity) was calculated by homeostasis model assessment (HOMA). Results:
Clinical and biochemical findings were compared with the components of the IRS, and demonstrated that a rise in fasting as
well as 30-min insulin secretion increases as abdominal body fat (obesity) increases. There was also a significant and proportional
correlation between the magnitude of abdominal obesity and the components of metabolic syndrome. Conclusion: Abdominal adiposity
appears to have a pivotal role in the development of IRS. 相似文献
70.
Total en-bloc calcanectomy was performed in a 36-year-old male patient with a giant cell tumor in his right calcaneus. A year after surgery, the patient had no complaints, and a good functional result was obtained. He was able to return to his work. No local or metastatic recurrences were encountered. 相似文献