收费全文 | 4216647篇 |
免费 | 340398篇 |
国内免费 | 13843篇 |
耳鼻咽喉 | 58680篇 |
儿科学 | 135076篇 |
妇产科学 | 110630篇 |
基础医学 | 651929篇 |
口腔科学 | 113503篇 |
临床医学 | 383256篇 |
内科学 | 761228篇 |
皮肤病学 | 106004篇 |
神经病学 | 350724篇 |
特种医学 | 163748篇 |
外国民族医学 | 503篇 |
外科学 | 647409篇 |
综合类 | 119508篇 |
现状与发展 | 23篇 |
一般理论 | 2627篇 |
预防医学 | 354486篇 |
眼科学 | 98865篇 |
药学 | 294955篇 |
26篇 | |
中国医学 | 11304篇 |
肿瘤学 | 206404篇 |
2021年 | 55883篇 |
2020年 | 35604篇 |
2019年 | 58612篇 |
2018年 | 73895篇 |
2017年 | 56465篇 |
2016年 | 62514篇 |
2015年 | 75481篇 |
2014年 | 109855篇 |
2013年 | 175094篇 |
2012年 | 121704篇 |
2011年 | 127250篇 |
2010年 | 125547篇 |
2009年 | 126754篇 |
2008年 | 113281篇 |
2007年 | 120606篇 |
2006年 | 129369篇 |
2005年 | 124497篇 |
2004年 | 124631篇 |
2003年 | 114935篇 |
2002年 | 104111篇 |
2001年 | 149709篇 |
2000年 | 144573篇 |
1999年 | 134351篇 |
1998年 | 70142篇 |
1997年 | 66217篇 |
1996年 | 64432篇 |
1995年 | 59696篇 |
1994年 | 53779篇 |
1993年 | 50045篇 |
1992年 | 96050篇 |
1991年 | 92644篇 |
1990年 | 89058篇 |
1989年 | 86817篇 |
1988年 | 80022篇 |
1987年 | 78512篇 |
1986年 | 73854篇 |
1985年 | 72980篇 |
1984年 | 61665篇 |
1983年 | 55431篇 |
1982年 | 46025篇 |
1981年 | 43119篇 |
1980年 | 40506篇 |
1979年 | 53100篇 |
1978年 | 44032篇 |
1977年 | 38884篇 |
1976年 | 36264篇 |
1975年 | 36276篇 |
1974年 | 39409篇 |
1973年 | 37632篇 |
1972年 | 35245篇 |
Design: A mixed-methods design, applying the Schwartz and Sprangers response shift (RS) model. RS is a cognitive process wherein, in response to a change in health status, individuals change internal standards, values, or conceptualization of QOL
Setting: Community-dwelling participants who receive medical treatment at a major Midwestern medical system and nearby Veterans’ Affairs hospital.
Participants: A purposive sample of participants with SCI (N?=?40) completed semi-structured interviews and accompanying quantitative measures.
Interventions: Not applicable.
Outcome Measures: Qualitative data were analyzed using content analysis to identify themes. Analysis of variance were performed to detect differences based on themes and QOL, well-being, and demographic and injury characteristics.
Results: Four RS themes were identified, capturing the range of participant perceptions of QOL. The themes ranged from complete RS, indicating active engagement in maintaining QOL, to awareness and comparisons redefining QOL, to a relative lack of RS. Average QOL ratings differed as a function of response shift themes. PROMIS Global Health, Anxiety, and Depression also differed as a function of RS themes.
Conclusion: The RS model contextualizes differences in QOL definitions, appraisals, and adaptations in a way standardized QOL measures alone do not. 相似文献
Objective
The teaching hospital of Nancy, France, implemented a specific multidisciplinary care pathway (French acronym AMDPL) to improve the management of patients presenting with Lyme borreliosis (LB) suspicion. We aimed to assess the first year of activity of this care pathway.Patients and methods
We included all patients managed in the AMDPL pathway from November 1, 2016 to October 31, 2017. The first step was a dedicated Lyme disease consultation with an infectious disease specialist. Following this consultation, the LB diagnosis was either confirmed and adequate treatment was prescribed, or a differential diagnosis was established and patients received adequate management, or further investigations were required and patients were offered multidisciplinary management as part of a day hospitalization.Results
A total of 468 patients were included. LB diagnosis was confirmed in 15% of patients (69/468), 49% of patients received a differential diagnosis, and 26% (122/468) of patients had the LB diagnosis ruled out without receiving any other diagnosis.Conclusions
This is to our knowledge the first multidisciplinary center implemented in France for the management of patients presenting with LB suspicion related to polymorphous signs and symptoms. Several diagnoses could be confirmed or corrected, although some symptoms and complaints could not be explained. This cohort could improve our knowledge of LB and its differential diagnoses. 相似文献Methods: [11C]WAY100635, [18F]altanserin and positron emission tomography were used to compare 5-HT1A and 5-HT2A binding in MDD patients divided into eight past suicide attempters (>4yrs prior to scanning) and eight lifetime non-attempters, and both groups were compared to eight healthy volunteers.
Results: The two receptor types differed in binding pattern across brain regions from each other, but there were no differences in binding between healthy volunteers and the two depressed groups or between depressed suicide attempters and non-attempters. No effects of depression severity or lifetime aggression were observed for either receptor.
Conclusion: Limitations of this study include small sample size and absence of high lethality suicide attempts in the depressed attempter group. No trait-like binding correlations with past suicide attempt or current depression were observed. Given the heterogeneity of nonfatal suicidal behavior, a larger sample study emphasizing higher lethality suicide attempts may find the serotonin biological phenotype seen in suicide decedents. 相似文献