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881.
Autoimmunity as an aetiological factor in vitiligo 总被引:2,自引:0,他引:2
N Rezaei†‡ NG Gavalas‡ AP Weetman‡ EH Kemp‡ 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):865-876
Vitiligo is a common dermatological disorder characterized by the presence on the skin of depigmented macules resulting from the destruction of cutaneous melanocytes. Autoimmunity is an important hypothesis with regard to vitiligo aetiology and the evidence for autoimmune responses being involved in the pathogenesis of this disorder will be discussed in the present review. All immune system compartments, including innate and adaptive immunity have been implicated in vitiligo development. Particularly relevant are autoantibodies and autoreactive T cells in vitiligo patients that have cytotoxic effects upon pigment cells. Furthermore, predisposition to vitiligo appears to be associated with certain alleles of the major histocompatibility complex class II antigens as well as with other autoimmune-susceptibility genes. Moreover, the association of vitiligo with autoimmune disorders, the animal models of the disease, and the positive response to immunosuppressive therapeutic agents emphasize the role of autoimmunity in the development of this disorder. 相似文献
882.
Wen Lu Alyssa Ziman Matthew T. S. Yan Allison Waters Mrigender Singh Virk Ann Tran Hongying Tang Andrew W. Shih Edel Scally Jay S. Raval Suchi Pandey Monica B. Pagano Hua Shan Carmel Moore Douglas Morrison Orla Cormack Joan Fitzgerald Jennifer Duncan Jessica Corean Gwen Clarke Mark Yazer 《Transfusion》2023,63(4):817-825
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Ryan A. Metcalf Claudia S. Cohn Sara Bakhtary Thomas Gniadek Gaurav Gupta Sarah Harm Richard L. Haspel Aaron S. Hess Jessica Jacobson Parvez M. Lokhandwala Colin Murphy Jacqueline N. Poston Micah T. Prochaska Jay S. Raval Nabiha H. Saifee Eric Salazar Hua Shan Nicole D. Zantek Monica B. Pagano 《Transfusion》2023,63(8):1590-1600
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Yvonne Nong MS Jessica Maloh ND Nicole Natarelli BA Hemali B. Gunt PhD Esther Tristani PhD Raja K. Sivamani MD MS AP 《Journal of Cosmetic Dermatology》2023,22(8):2166-2173
Background
Beeswax is a naturally occurring product secreted from worker bees that has varied uses in modern day. In skincare, its function ranges from its role as an occlusive, helping to create a semi-occlusive skin barrier that minimizes transepidermal water loss; as a humectant, locking in hydration; and an emollient to soften and soothe the skin. As a natural substance, its use has been shown to help alleviate symptoms associated with common cutaneous conditions like dermatitis, psoriasis, and overgrowth of normal skin flora.Aims
In this narrative review, we aim to describe current uses of beeswax in skincare that has been published in the literature.Materials and methods
A review of beeswax related publications was performed by searching the PubMed database studies.Results
A total of five clinical studies were included with three studies on animals and two studies in humans.Discussion
Several studies show the benefits of topical beeswax in supporting the skin barrier.Conclusion
Beeswax can be a low-cost, natural ingredient for use in products. Further studies with topical beeswax are warranted. 相似文献888.
Mark H. Yazer Nancy M. Dunbar John R. Hess Erin E. Tuott Mohammad Bahmanyar Jessica Campbell Magali Fontaine Ara Ko Jian Mi Michael F. Murphy Jessica Poisson Jay S. Raval Andrew W. Shih Jason L. Sperry Julie Staves Michelle Wong Matthew T. S. Yan Alyssa Ziman Jansen N. Seheult 《Transfusion》2023,63(Z3):S46-S53
Background
Questions persist about the safety of switching non-group O recipients of group O uncrossmatched red blood cells (RBC) or low titer group O whole blood (LTOWB) to ABO-identical RBCs during their resuscitation.Methods
The database of an earlier nine-center study of transfusing incompatible plasma to trauma patients was reanalyzed. The patients were divided into three groups based on 24-h RBC transfusion: (1) group O patients who received group O RBC/LTOWB units (control group, n = 1203), (2) non-group O recipients who received only group O units (n = 646), (3) non-group O recipients who received at least one unit of group O and non-group O units (n = 562). Fixed marginal effect of receipt of non-O RBC units on 6- and 24-h and 30-day mortality was calculated.Results
The non-O patients who received only group O RBCs received fewer RBC/LTOWB units and had slightly but significantly lower injury severity score compared to control group; non-group O patients who received both group O and non-O units received significantly more RBC/LTOWB units and had a slightly but significantly higher injury severity score compared to control group. In the multivariate analysis, the non-O patients who received only group O RBCs had significantly higher mortality at 6-h compared to the controls; the non-group O recipients of O and non-O RBCs did not demonstrate higher mortality. At 24-h and 30-days, there were no differences in survival between the groups.Conclusion
Providing non-group O RBCs to non-group O trauma patients who also received group O RBC units is not associated with higher mortality. 相似文献889.
Bailey Roberts Jo Cooke-Barber Martha-Conley Ingram Melissa Danko Maeve Trudeau Richard D. Glick Scott S. Short Daniel J. Robertson Mehul V. Raval Roshni Dasgupta Barrie S. Rich the American Academy of Pediatrics Section on Surgery Delivery of Surgical Care Committee 《Pediatric blood & cancer》2023,70(7):e30355