The New Brunswick Health Council at a glance

This article presents an overview of the work of the New Brunswick Health Council (NBHC) since its creation by exploring its mandate and by presenting its different initiatives and publications as they relate to the NBHC's areas of work: population health, care experience, sustainability, and citizen engagement.     

Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins

A 75-year-old man with hairy cell leukemia (HCL) was found to have an immunoblastic lymphoma of the small bowel. Immunologic and genotypic characterization of these neoplasms revealed both the HCL and the immunoblastic lymphoma to be of the B cell lineage. The HCL expressed the HCL-associated antigens detected by the monoclonal antibodies HC-1 and HC-2, whereas the immunoblastic lymphoma failed to react with these antibodies. In addition, surface immunoglobulin light chains could not be accurately determined for the hairy cells, whereas the immunoblastic lymphoma was shown to express only kappa immunoglobulin light chains. These immunophenotype differences were compatible with either the clonal evolution of the HCL into the immunoblastic lymphoma or a separate clonal origin for these two neoplasms. An analysis of tumor DNA by Southern blot hybridization revealed different heavy-chain and kappa light-chain gene rearrangements in these two malignancies. Thus the occurrence of the large cell lymphoma most likely represents the emergence of a second clonally unrelated B cell malignancy.     

Two hospitals with 1 trauma system: a joint approach to the care of the injured patient

BackgroundTrauma centers are closing at an alarming rate, but the need for trauma care persists. This article shows the sustainability and feasibility of a joint trauma system whereby 2 university-affiliated hospitals function as a single trauma center system in a moderate-sized city.MethodsSince 1994, 3 days per week, trauma patients are transported by emergency medical services (EMS) to hospital A. The other 4 days they are transported to hospital B. Trauma registry data from 1994 to 2008 were analyzed. Cost data were also examined.ResultsThe joint system admitted 28,338 trauma patients. On each center's nontrauma days, trauma team activation was required infrequently. The 2 centers share costs; they perform joint outreach, educational training, and quality control. The joint trauma system has been sustained since 1994.ConclusionsTwo hospitals functioning as a single trauma center system is a viable model of care for injured patients in a moderate-sized city with mostly blunt trauma.     

螺旋CT图像噪声的评价

目的 :评价螺旋CT中内插方式、螺距以及重建间隔对噪声的影响。方法 :采用SomatomPlus 4螺旋CT机。在相同条件下扫描直径为 2 0cm的水模 ,测得水模图像中心 40cm2 兴趣区的CT值标准差作为评价噪声水平的指标。结果 :3 60°线性内插的噪声减少 (t =3 4.87,P <0 .0 0 1) ,180°线性内插的噪声增加 (t =18.78,P <0 .0 0 1)。螺距大于 1.0或小于 1.0与螺距为 1.0时噪声水平的差异无显著性意义 (P >0 .0 5 )。随着重建间隔改变 ,相应噪声水平的差异无显著性意义 (P >0 .0 5 )。结论 :与常规扫描相比 ,螺旋CT内插方式对噪声有一定影响 ,而螺距与重建间隔对噪声水平影响不明显。     

胰腺癌可切除性的CT研究

４３例胰腺癌均经手术和／或病理证实，其中１０例经胰十二指肠切除术切除。本文复习ＣＴ所见，初步认为下列表现是胰腺癌不可切除的ＣＴ征象：（１）胰头癌距肝门的距离少于４ｃｍ；（２）肠系膜上动脉、下腔静脉、腹主动脉、胃、肝、脾、左肾及较大范围的肠系膜上静脉浸润；（３）肝转移。腹水、肠系膜上动脉周围脂层的单纯消失均不是判断不可切除的可靠征象。     

外伤性脑梗死的CT诊断(附39例分析)

目的：探讨螺旋CT在外伤性脑梗死诊断中的价值及其特征。方法：对39例头颈部外伤后临床主要表现为不同程度的偏瘫患者行横断面螺旋CT扫描，分析外伤性脑梗死的CT表现。结果：根据临床和CT表现分为两型：I型(21例)，外伤性腔隙性脑梗死，好发于基底节-内囊区，均位于豆状核、尾状核及内囊区，呈小片状腔隙性低密度区；Ⅱ型(18例)，外伤性大面积脑梗死，为脑叶梗死呈扇形低密度区，与大脑前中后供血动脉或颈内动脉分布一致，范围较大。结论：螺旋CT扫描检查对外伤性脑梗死的准确诊断、估计病变程度，分析两型脑梗死的不同发生机制，为临床诊断、治疗及判断预后提供重要信息。     

带红系增强子的人β珠蛋白基因在转基因小鼠中的表达

带红系增强子的人β珠蛋白基因在转基因小鼠中的表达李政刘德培刘庆辉郭志晨章秋珩李志杰贾佩臣梁植权β４１／４２是印度次大陆、东南亚及我国南方常见的一种血红蛋白病，纯合子呈严重的β－地中海贫血。本实验旨在建立带红系，增强子５′ＨＳ２的人β４１／４２珠蛋白基...