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Sonja Cekić Dijana Risimić Gordana Stanković-Babić Rade Babić Vesna Jakšić Ivan Jovanović Jasmina Đorđević-Jocić 《Central European Journal of Medicine》2012,7(1):100-107
We present three different cases of patients with papilledema: one case with a primary tumour of the optic nerve, and two
cases with secondary involvement of the optic nerve (breast carcinoma and non-Hodgkin lymphoma). The visual acuity varies
from sudden, painless, decrease of vision, to blurred vision and proptosis on the affected eye. A characteristic ophthalmoscopic
examination shows a swollen optic disc and promonence with tortuosity of blood vessels. A fluorescein angiography shows dilated
capillaries of the optic disc with leakage in the early phase and diffuse hyperfluorescence during the late phase. A ultrasonography
B-scan of the affected eye shows prominent optic nerves with widened optic nerve sheath. An exhaustive history and complete
ophthalmological examination are essential for the diagnosis, to which fluorescein angiography, B-scan ultrasonography, ocular
coherent tomography, computerized tomography, and magnetic resonance can be used as useful additional tests. Treatment and
prognosis depend on the primary process. We emphasize the crucial role of ophthalmologist in the early diagnosis of CNS neoplasia. 相似文献
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Ljubinka Jankovic Velickovic Takanori Hattori Zana Dolicanin Milan Visnjic Miljan Krstic Ivan Ilic Rade Cukuranovic Milena Rajic Vladisav Stefanovic 《Pathology, research and practice》2009
Upper urothelial carcinoma (UUC), a rare neoplasm, occurs more frequently in some regions of Balkan countries than in other areas in the world. The aim of this study is to compare phenotypic morphological characteristics of UUC in Balkan endemic nephropathy (BEN) region and control rural and city populations free of BEN, and to determine the characteristic(s) that could discriminate tumors in endemic and non-endemic regions. The authors analyzed biopsies from 88 patients with UUC, 40 patients who live in Balkan endemic (BEN) settlements and 48 control subjects. The histological sections were used to assess morphological variables: histologic grade, pathologic stage (pT), growth pattern, pattern of invasion, lympho-vascular invasion (LVI), presence of necrosis and metaplastic changes (squamous or glandular) within the tumor. Statistically significant differences between the groups were found concerning tumor grade, pattern of invasion, growth pattern and metaplastic changes. High-grade tumors and trabecular/infiltrative patterns of invasion were more frequent in the group of BEN tumors (χ2=4.583, p<0.05; χ2=8.064, p<0.05). Moreover, solid growth and metaplastic changes are significant in BEN tumor, χ2=9.696, p<0.01; χ2=9.35, p<0.01, respectively. Discriminant analysis of morphological variables had indicated that BEN and control tumors are significantly different (Wilks’ lambda=0.833, χ2=15.044 and p<0.05). The best characteristic that differentiated them was growth pattern; i.e., solid growth for BEN tumors and papillary for control tumors. 相似文献
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Christopher Igiel DMD MSc Karl Martin Lehmann DMD PhD Razvan Ghinea PhD MSc BSc GOO Michael Weyhrauch DMD Ysbrand Hangx DMD Herbert Scheller DMD PhD Rade D. Paravina DDS MS PhD 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》2017,29(5):303-308