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Gefitinib is an epidermal growth factor tyrosine kinase inhibitor used as a targeted chemotherapeutic agent in the treatment
of lung cancer and other solid malignancies. Unlike other tyrosine kinase inhibitors, gefitinib is not recognized as having
significant cardiotoxicity though it has been reported to be capable of potentiating ADP-induced activation and thromboxane
A2 generation in platelets which could promote thrombosis. We report a case of recurrent myocardial infarction with angiographically
documented vulnerable plaque rupture in a patient receiving chronic gefitinib therapy for metastatic carcinoid tumor. Platelet
function studies revealed marked ADP-induced platelet activation that was only suppressed by high-dose clopidogrel. Measurement
of urine 11-dehydro-thromboxane B2 also indicated persistent thromboxane A2 generation despite aspirin therapy, an emerging risk factor for adverse cardiovascular events. 相似文献
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Juraj Kuniek Luka Zaputovi arko Mavri Leon Kuniek Irena Bruketa-Marki Rade Karlavaris Ksenija Lukin-Ekinja 《Medizinische Klinik》2008,103(10):705-711
Abstract
Purpose:
To investigate the correlation between the prevalence of ventricular arrhythmias (VA) and the type and degree of left ventricular
hypertrophy (LVH) in hypertensive patients using exercise testing and Holter monitoring.
Patients and Methods:
A total of 192 patients (87 men and 105 women) without coronary disease were divided into three groups according to type of
LVH (concentric, eccentric, and asymmetric) and three subgroups in relation to the degree of hypertrophy (mild, moderate,
and severe). In all subjects blood pressure was measured, electrocardiographic and echocardiographic data obtained and the
prevalence of VA determined by Holter monitoring and bicycle ergometry.
Results:
The most frequent LVH type was the concentric (63%), followed by eccentric (28%) and asymmetric (9%). Severe LVH was found
in 10% of patients. Complex VA during Holter monitoring were identified in > 40% of patients. During the stress test this
percentage increased by additional 7.4%. There was no statistically significant difference between groups in frequency of
simple (p = 0.757) and complex (p = 0.657, p = 0.819, p = 0.617, for polytopic, pairs and ventricular tachycardia, respectively)
VA. Increased prevalence of VA was found for the moderate and severe degree in all types. In the concentric type the difference
was statistically significant for simple VA (p = 0.042).
Conclusion:
There was no correlation between type of LVH and prevalence of VA. The severity of hypertrophy contributes more to a greater
prevalence of VA than the LVH pattern. The combination of severe degree and concentric type carries the greatest cardiovascular
risk.
相似文献
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Simon J Corbett John Cosgrave Gloria Melzi Rade Babic Giuseppe G L Biondi-Zoccai Cosmo Godino Nuccia Morici Flavio Airoldi Iassen Michev Matteo Montorfano Giuseppe M Sangiorgi Erminio Bonizzoni Antonio Colombo 《European heart journal》2006,27(19):2330-2337
AIM: To evaluate patterns of restenosis following implantation of sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) in comparable unselected lesions. METHODS AND RESULTS: We have identified all episodes of restenosis after SES or PES implantation in our institutions between March 2003 and March 2005. Restenosis pattern was classified as focal, diffuse, proliferative, or occlusive. The position of focal restenosis was also categorized as proximal, in-stent, distal, or multi-focal. We have characterized 150 and 149 restenotic lesions in SES and PES groups, respectively. The incidence of diffuse and occlusive restenosis was significantly higher in PES than in SES (47.6 vs. 27.0%, P < 0.001). Multivariable (OR 2.693, 95% CI 1.425-5.089, P = 0.002) and propensity (OR 3.00, 95% CI 1.584-5.672, P < 0.001) analyses confirmed the positive association of PES with non-focal restenosis. For both stents, focal-edge restenosis was significantly more likely to occur proximally than distally (61.0 vs. 16.9%, P < 0.001 for PES and 45.8 vs. 16.8%, P < 0.001 for SES). CONCLUSION: Focal restenosis remains the most common pattern with SES. In contrast, just under half of restenosis in PES is the more severe non-focal pattern. Paradoxically, the majority of focal restenosis occurs at the proximal stent margin for both platforms. 相似文献
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