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991.
Uwe Güth Simone Rachel Kann Dorothy Jane Huang Andreas Schötzau Wolfgang Holzgreve Edward Wight 《Archives of gynecology and obstetrics》2009,280(5):719-724
Purpose
To demonstrate how the current concept of recurrent ovarian carcinoma (ROC) as a chronic disease resulted in developments in the systemic treatment strategies and outcome over time. 相似文献992.
Matthias Luebbert Debbie Radtke Rachel Wodarski Nils Damann Hanns Hatt Christian H. Wetzel 《Pflügers Archiv : European journal of physiology》2010,459(5):737-750
TRPV1 is a member of the transient receptor potential (TRP) family of cation channels. It is expressed in sensory neurons of the dorsal root and trigeminal ganglia as well as in a wide range of non-neuronal tissues. The channel proteins serve as polymodal receptors for various potentially harmful stimuli to prevent tissue damage by mediating unpleasant or painful sensations. Using Ca imaging and voltage-clamp recordings, we found that low millimolar doses of Ni2+ (NiSO4) are able to induce non-specific cation currents in a capsaicin-sensitive population of cultured mouse trigeminal ganglion neurons. In addition, we show that NiSO4 elicits intracellular Ca2+ transients and membrane currents in HEK293 and CHO cells heterologously expressing rat TRPV1. The use of voltage ramps from ?100 to +100 mV revealed a strong outward rectification of these currents. Application of NiSO4 to the cytoplasmic face of inside-out membrane patches did not induce any currents. However, delivering NiSO4 to the extracellular face during outside-out recordings, we observed a significant increase in open probability paralleled by a decrease in channel conductance. When combined with other TRPV1 agonists, NiSO4 produces a bimodal effect on TRPV1 activity, depending on the strength and concentration of the second stimulus. Outwardly directed currents induced by low doses of capsaicin and nearly neutral pH values (~pH?=?7.0–6.5) were augmented by low doses of NiSO4. In contrast, responses to stronger stimuli were reduced by NiSO4. Moreover, we were able to identify amino acids involved in the effect of NiSO4 on TRPV1. 相似文献
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Rachel Nonkin Avchen Lisa D. Wiggins Owen Devine Kim Van Naarden Braun Catherine Rice Nancy C. Hobson Diana Schendel Marshalyn Yeargin-Allsopp 《Journal of autism and developmental disorders》2011,41(2):227-236
We conducted the first study that estimates the sensitivity, specificity, positive predictive value (PPV), and negative predictive
value (NPV) of a population-based autism spectrum disorders (ASD) surveillance system developed at the Centers for Disease
Control and Prevention. The system employs a records-review methodology that yields ASD classification (case versus non-ASD
case) and was compared with classification based on clinical examination. The study enrolled 177 children. Estimated specificity
(0.96, [CI.95 = 0.94, 0.99]), PPV (0.79 [CI.95 = 0.66, 0.93]), and NPV (0.91 [CI.95 = 0.87, 0.96]) were high. Sensitivity was lower (0.60 [CI.95 = 0.45, 0.75]). Given diagnostic heterogeneity, and the broad array of ASD in the population, identifying children with ASD
is challenging. Records-based surveillance yields a population-based estimate of ASD that is likely conservative. 相似文献
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Rachel M. Zamzow Bradley J. Ferguson Alexandra S. Ragsdale Morgan L. Lewis 《Journal of clinical and experimental neuropsychology》2017,39(6):596-606
Autism spectrum disorder (ASD) is characterized by impairments in social communication as well as restricted, repetitive behaviors. Evidence suggests that some individuals with ASD have cognitive impairments related to weak central coherence and hyperrestricted processing. Reducing noradrenergic activity may improve aspects of network processing and thus improve cognitive abilities, such as verbal problem solving, in individuals with ASD. The present pilot study explores the effects of acute administration of the beta-adrenergic antagonist propranolol on verbal problem solving in adults and adolescents with ASD. In a within-subject crossover-design, 20 participants with ASD received a single dose of propranolol or placebo on one of two sessions in a double-blinded, counterbalanced manner. Verbal problem solving was assessed via an anagram task. Baseline measurements of autonomic nervous system functioning were obtained, and anxiety was assessed at baseline and following drug administration. Participants solved the anagrams more quickly in the propranolol condition, as compared to the placebo condition, suggesting a potential cognitive benefit of this agent. Additionally, we observed a negative linear relationship between response to propranolol on the anagram task and two measures of baseline autonomic activity, as well as a positive linear relationship between drug response and baseline anxiety. These relationships propose potential markers for treatment response, as propranolol influences both autonomic functioning and anxiety. Further investigation is needed to expand on the present single-dose psychopharmacological challenge and explore the observed effects of propranolol in a serial-dose setting. 相似文献
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